Tranexamic Acid : Nebulization vs IV Route for Hemoptysis

NCT07212452 | Completed Phase 2 DMC

• 1 other identifier: #NTranexamic#
• Study Type: interventional
• Target: 172
• Locations: 1 country
• Sites: 1

Brief Summary

This study compares the effect of tranexamic acid on hemoptysis when given through the conventional IV route and Through nebulization.

Conditions

Hemoptysis; NEBULIZATION; Tranexamic Acid

Keywords

Hemoptysis; Nebulization; tranexamic acid

Outcome Measures

Primary Outcomes (1)

• Time to control hemoptysis

  In this study the time taken by tranexamic acid to acehive comolete control of hemoptysis will be compared when given through IV and nebulization.

  48 hours

Study Arms (2)

Group receiving tranexamic acid via IV route

ACTIVE COMPARATOR

Tranexamic acid has been used conventionally for hemoptysis via IV route

Drug: Tranexamic Acid (TXA)

The Group receiving tranexamic acid via nebulization

EXPERIMENTAL

Tranexamic acid when given through nebulization can be more effective than IV route in controlling hemoptysis

Drug: Tranexamic Acid (TXA)

Interventions

Tranexamic Acid (TXA) DRUG

In this study we are comparing the effect of tranexamic acid on hemoptysis when given through IV route and nebulization

Also known as: nebulization

Group receiving tranexamic acid via IV route; The Group receiving tranexamic acid via nebulization

Eligibility Criteria

• Age: 12 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with mild to moderate hemoptysis \< 600ml/ 24 hours of age 12 to 80 years and both genders.
• Patients with hemoptysis due to infective pathology.
• Patients with hemoptysis due to malignant pathology.

You may not qualify if:

• Patients on antiplatelet therapy or aspirin
• Hemoptysis after penetrating lung injury e.g. firearm injury
• Patients with history of asthma

Sponsors & Collaborators

• University of Health Sciences Lahore: lead

Study Sites (1)

Services Hospital Lahore

Lahore, Punjab Province, 54000, Pakistan

Location

Related Publications (1)

• Gopinath B, Mishra PR, Aggarwal P, Nayaka R, Naik SR, Kappagantu V, Shrimal P, Ramaswami A, Bhoi S, Jamshed N, Sinha TP, Ekka M, Kumar A. Nebulized vs IV Tranexamic Acid for Hemoptysis: A Pilot Randomized Controlled Trial. Chest. 2023 May;163(5):1176-1184. doi: 10.1016/j.chest.2022.11.021. Epub 2022 Nov 19.

  PMID: 36410494 RESULT

Related Links

• The sample article is available through this link

MeSH Terms

Conditions

Hemoptysis

Interventions

Tranexamic Acid

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms, Respiratory; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Cyclohexanecarboxylic Acids; Acids, Carbocyclic; Carboxylic Acids; Organic Chemicals

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: There is no masking as the participnats will be explained the whole process and consent would be taken for using the either route for administration of tranexamic acid
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: The intervention will be given to the participants via providing the tranexamic acide through both IV and nebulization routes.

Study Record Dates

• First Submitted: September 30, 2025
• First Posted: October 8, 2025
• Study Start: August 1, 2025
• Primary Completion: October 31, 2025
• Study Completion: October 31, 2025
• Last Updated: November 28, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)