Prevalence of Latent Tuberculosis Infection Among Hemodialysis Patients

NCT07210970 | Not Yet Recruiting

• 1 other identifier: Soh-Med--25-9-5MS
• Study Type: observational
• Target: 200
• Locations: 0 countries
• Sites: N/A

Brief Summary

This observational cross-sectional study aims to determine the prevalence of latent tuberculosis infection (LTBI) among patients undergoing regular hemodialysis at Sohag University Hospital, using the tuberculin skin test (TST). Identifying the burden of LTBI in this high-risk population will help guide early detection and preventive strategies

Conditions

Latent Tuberculosis Infection; End Stage Renal Disease (ESRD); Hemodialysis

Outcome Measures

Primary Outcomes (1)

• Prevalence of latent tuberculosis infection among hemodialysis patients.

  Percentage of patients with positive tuberculin skin test (defined as induration ≥10 mm).

  Within 72 hours after TST administration.

Study Arms (1)

Hemodialysis Patients

Adult patients undergoing regular hemodialysis at Sohag University Hospital who will be screened for latent tuberculosis infection.

Diagnostic Test: Tuberculin Skin Test (TST)

Interventions

Tuberculin Skin Test (TST) DIAGNOSTIC_TEST

Intradermal injection of 5 unit (0.1 mm) of purified protein derivative (PPD) with measurement of induration after 48-72 hours.

Hemodialysis Patients

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients undergoing regular hemodialysis at Sohag University Hospital. The study will include patients aged 18 years and older who are clinically stable and able to undergo tuberculin skin testing

You may qualify if:

• Age ≥ 18 years Patients on regular hemodialysis Able and willing to provide informed consent

You may not qualify if:

• active TB patients

Sponsors & Collaborators

• Sohag University: lead

MeSH Terms

Conditions

Latent Tuberculosis; Kidney Failure, Chronic

Interventions

Tuberculin Test

Condition Hierarchy (Ancestors)

Tuberculosis; Mycobacterium Infections; Actinomycetales Infections; Gram-Positive Bacterial Infections; Bacterial Infections; Bacterial Infections and Mycoses; Infections; Latent Infection; Renal Insufficiency, Chronic; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Skin Tests; Immunologic Tests; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques; Immunologic Techniques

Study Officials

• Fatma A Ibrahim, MSc

  Faculty of Medicine, Sohag University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Fatma Ahmed Ibrahim

Study Record Dates

• First Submitted: September 30, 2025
• First Posted: October 7, 2025
• Study Start: December 1, 2025
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 20, 2027
• Last Updated: October 7, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share