Six Minutes Walk Test in Children on Regular Hemodialysis

NCT06910319 | Not Yet Recruiting

• 1 other identifier: 6 minutes walk test
• Study Type: observational
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

To evaluate exercise tolerance and the reproducibility of the six minute walk test in children and adolescents with ESRD on regular hemodialysis and to compare their functional exercise capacities with reference values for healthy children. To investigate predictors of poor 6MWT performance in children on regular HD

Conditions

Hemodialysis

Outcome Measures

Primary Outcomes (1)

• To evaluate the reproducibility of the six-minute walk test in children and adolescents with end stage renal disease on regular dialysis

  One year from may 2025 to may 2026

Eligibility Criteria

• Age: 1 Year - 18 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The patient observed the researcher performing the test and then was instructed to walk as far as possible for 6- min and maintain a normal walking pace. Patients are able to interrupt the test if necessary. At each minute of walking the researcher communicated clearly and calmly how many minutes remained until the end of the test. In the end, the walked distance will be measured. HR, %HRmax, SpO2, SBP, and DBP delta values are to be measured before and after participating test. During the test the researcher will monitor the patient for untoward signs and symptoms while using a stop watch to calculate time of the walked distance.If the patient stops before the 6 minutes are up and refuse to continue or the researcher decide that they should not continue, the researcher must wheel the chair over for the patient to sit on, discontinue the walk and note on the worksheet the distance , the time stopped and the reason for stopping prematurely.

You may qualify if:

• Children with ESRD who on regular hemodialysis at Assiut University Children Hospital .

You may not qualify if:

• Any subject with underlying primary cardio-pulmonary disease or condition that interfere with the walk test as hemiplegia and cerebral palsy.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (15)

• Watanabe FT, Koch VH, Juliani RC, Cunha MT. Six-minute walk test in children and adolescents with renal diseases: tolerance, reproducibility and comparison with healthy subjects. Clinics (Sao Paulo). 2016 Jan;71(1):22-7. doi: 10.6061/clinics/2016(01)05.

  PMID: 26872080 BACKGROUND

• Lipkin DP, Scriven AJ, Crake T, Poole-Wilson PA. Six minute walking test for assessing exercise capacity in chronic heart failure. Br Med J (Clin Res Ed). 1986 Mar 8;292(6521):653-5. doi: 10.1136/bmj.292.6521.653.

  PMID: 3081210 BACKGROUND

• Gayda M, Temfemo A, Choquet D, Ahmaidi S. Cardiorespiratory requirements and reproducibility of the six-minute walk test in elderly patients with coronary artery disease. Arch Phys Med Rehabil. 2004 Sep;85(9):1538-43. doi: 10.1016/j.apmr.2003.11.037.

  PMID: 15375831 BACKGROUND

• Painter P. Physical functioning in end-stage renal disease patients: update 2005. Hemodial Int. 2005 Jul;9(3):218-35. doi: 10.1111/j.1492-7535.2005.01136.x.

  PMID: 16191072 BACKGROUND

• Bittner V, Weiner DH, Yusuf S, Rogers WJ, McIntyre KM, Bangdiwala SI, Kronenberg MW, Kostis JB, Kohn RM, Guillotte M, et al. Prediction of mortality and morbidity with a 6-minute walk test in patients with left ventricular dysfunction. SOLVD Investigators. JAMA. 1993 Oct 13;270(14):1702-7.

  PMID: 8411500 BACKGROUND

• Savci S, Inal-Ince D, Arikan H, Guclu-Gunduz A, Cetisli-Korkmaz N, Armutlu K, Karabudak R. Six-minute walk distance as a measure of functional exercise capacity in multiple sclerosis. Disabil Rehabil. 2005 Nov 30;27(22):1365-71. doi: 10.1080/09638280500164479.

  PMID: 16372431 BACKGROUND

• Du H, Newton PJ, Salamonson Y, Carrieri-Kohlman VL, Davidson PM. A review of the six-minute walk test: its implication as a self-administered assessment tool. Eur J Cardiovasc Nurs. 2009 Mar;8(1):2-8. doi: 10.1016/j.ejcnurse.2008.07.001. Epub 2008 Aug 9.

  PMID: 18694656 BACKGROUND

• Painter P, Krasnoff J, Mathias R. Exercise capacity and physical fitness in pediatric dialysis and kidney transplant patients. Pediatr Nephrol. 2007 Jul;22(7):1030-9. doi: 10.1007/s00467-007-0458-6. Epub 2007 Mar 20.

  PMID: 17372771 BACKGROUND

• Takken T, Engelbert R, van Bergen M, Groothoff J, Nauta J, van Hoeck K, Lilien M, Helders P. Six-minute walking test in children with ESRD: discrimination validity and construct validity. Pediatr Nephrol. 2009 Nov;24(11):2217-23. doi: 10.1007/s00467-009-1259-x. Epub 2009 Jul 25.

  PMID: 19633871 BACKGROUND

• Pattaragarn A, Warady BA, Sabath RJ. Exercise capacity in pediatric patients with end-stage renal disease. Perit Dial Int. 2004 May-Jun;24(3):274-80.

  PMID: 15185776 BACKGROUND

• Weaver DJ Jr, Kimball TR, Knilans T, Mays W, Knecht SK, Gerdes YM, Witt S, Glascock BJ, Kartal J, Khoury P, Mitsnefes MM. Decreased maximal aerobic capacity in pediatric chronic kidney disease. J Am Soc Nephrol. 2008 Mar;19(3):624-30. doi: 10.1681/ASN.2007070773. Epub 2008 Jan 9.

  PMID: 18184856 BACKGROUND

• Sethna CB, Salerno AE, McBride MG, Shults J, Paridon SM, Sharma N, Meyers KE, Leonard MB. Cardiorespiratory fitness in pediatric renal transplant recipients. Transplantation. 2009 Aug 15;88(3):395-401. doi: 10.1097/TP.0b013e3181aed7d1.

  PMID: 19667944 BACKGROUND

• Lammers AE, Hislop AA, Flynn Y, Haworth SG. The 6-minute walk test: normal values for children of 4-11 years of age. Arch Dis Child. 2008 Jun;93(6):464-8. doi: 10.1136/adc.2007.123653. Epub 2007 Aug 3.

  PMID: 17675356 BACKGROUND

• Enright PL. The six-minute walk test. Respir Care. 2003 Aug;48(8):783-5.

  PMID: 12890299 BACKGROUND

• Solway S, Brooks D, Lacasse Y, Thomas S. A qualitative systematic overview of the measurement properties of functional walk tests used in the cardiorespiratory domain. Chest. 2001 Jan;119(1):256-70. doi: 10.1378/chest.119.1.256.

  PMID: 11157613 BACKGROUND

Study Officials

• Ahlam Badawy Ali, Assistant professor of pediat

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Caroline Fayez Abdelmalak, Pediatric residant doctor

CONTACT

01221010974; carolinefayez52@gmail.com

Salah Eldin Amry Ahmad, Professor of pediatrics

CONTACT

‪011 46082024‬; S_amry@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: March 21, 2025
• First Posted: April 4, 2025
• Study Start: May 1, 2025
• Primary Completion: May 1, 2026
• Study Completion: June 1, 2026
• Last Updated: April 4, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share