Knee Strengthening With Hip vs. Ankle Exercises in Women With Patellofemoral Pain Syndrome

NCT07210060 | Completed

• 1 other identifier: KMUHIRB-E(I)-20220334
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

Eight weeks of telehealth-based supervised exercise effectively reduced DKV and pain in women with anterior knee pain. Both intervention groups demonstrated comparable benefits.

Conditions

Patellofemoral Pain Syndrome; Anterior Knee Pain; Exercise Therapy

Keywords

Dynamic alignment; Tele-rehabilitation; Pain modulation; Muscle strength

Outcome Measures

Primary Outcomes (1)

• Single Leg Landing Task

  The participant stood on a 30 cm box and first bent the non-testing leg's knee to approximately 90 degrees. After stabilizing, the participant jumped forward with the testing leg to a target 10 cm away from the box, maintaining balance for five seconds upon landing.

  2 minute

Secondary Outcomes (5)

• Numeric Pain Rating Scale

  1 minute

• Patellar Tendon Stiffness Measurement

  3 minute

• Muscle structure

  15 minute

• Ankle Joint ROM

  3 minute

• Maximum Voluntary Isometric Strength

  15 minute

Study Arms (3)

HK group

EXPERIMENTAL

hip + knee joint exercise group

Other: hip + knee joint exercise group

AK group

EXPERIMENTAL

ankle + knee joint exercise group

Other: ankle + knee joint exercise group

Stretching group

SHAM COMPARATOR

Stretching group

Other: Stretching group

Interventions

hip + knee joint exercise group OTHER

Hip: squat, glute bridge and gluteus medius exercise Knee: knee flexor and extensor, isometric squat hold

HK group

ankle + knee joint exercise group OTHER

Knee: knee flexor and extensor, isometric squat hold Ankle: plantar flexor, dorsi flexor and lunge

AK group

Stretching group OTHER

Education Handout on Lower Limb Stretching

Stretching group

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Female recreational athletes aged 20-40 years who engage in regular exercise
• Experiencing pain in the anterior or surrounding patella during at least two or more of the following activities: walking, running, jumping, kneeling, squatting, climbing stairs, or prolonged sitting
• A pain index of 3 or higher on the Numeric Pain Rating Scale (NPRS) and symptoms persisting for at least 3 months
• Knee pain unrelated to trauma.

You may not qualify if:

• Inability to operate a smartphone or computer
• History of fractures or surgeries involving the hip, knee, ankle, or foot
• History of meniscus, knee ligament injuries, or ankle sprains within the last six months
• Knee ligament laxity, inflammation, swelling, patellar dislocation, or subluxation
• Cognitive impairment or inability to follow simple instructions
• History of cardiovascular or neurological disorders

Sponsors & Collaborators

• Kaohsiung Medical University Chung-Ho Memorial Hospital: lead

Study Sites (1)

Nai-Jen Chang

Tainan, Kaohsiung City, 807, Taiwan

Location

MeSH Terms

Conditions

Patellofemoral Pain Syndrome

Interventions

Papaverine

Condition Hierarchy (Ancestors)

Joint Diseases; Musculoskeletal Diseases

Intervention Hierarchy (Ancestors)

Benzylisoquinolines; Alkaloids; Heterocyclic Compounds; Opiate Alkaloids; Isoquinolines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 18, 2025
• First Posted: October 7, 2025
• Study Start: July 1, 2023
• Primary Completion: July 31, 2024
• Study Completion: July 31, 2024
• Last Updated: October 7, 2025

Record last verified: 2025-09

Locations

TW (1)