Economic Evaluation of Mindline.sg

NCT07209904 | Active Not Recruiting

• 1 other identifier: NUS-IRB-2025-228
• Study Type: interventional
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate the effectiveness of mindline.sg, a digital mental health platform, in improving mental health literacy, emotional wellbeing, quality of life, and economic outcomes among adults in Singapore. We will conduct a randomized controlled trial (RCT) with two phases: an initial screening and a 1-month intervention. Eligible participants, identified based on mental health symptom scores, will be randomly assigned to either an intervention group using mindline.sg or a control group receiving standard mental health information. The intervention group will receive weekly prompts to engage with key features of the platform, including psychoeducation, positive psychology tools, emotion regulation exercises, and access to digital navigation for mental health services. Participants in both groups will complete surveys at baseline, post-intervention, and two months post-intervention, measuring outcomes such as mental health symptoms, resilience, wellbeing, emotion regulation, mental health literacy, and work performance. We expect mindline.sg users to show greater improvements across mental health and quality of life indicators, increased mental health literacy, and better work productivity compared to controls. This study will provide evidence on the utility of digital mental health tools in supporting population mental wellbeing and inform future digital mental health strategies in Singapore and similar contexts.

Conditions

Healthy

Keywords

digital mental health

Outcome Measures

Primary Outcomes (3)

• Mental health symptoms by 21-item Depression, Anxiety and Stress Scale (DASS-21)

  The Depression, Anxiety and Stress Scale - 21 Items (DASS-21) is a set of three self-report scales designed to measure the emotional states of depression, anxiety and stress. Each of the three DASS-21 scales contains 7 items, divided into subscales with similar content. The depression scale assesses dysphoria, hopelessness, devaluation of life, self-deprecation, lack of interest / involvement, anhedonia and inertia. The anxiety scale assesses autonomic arousal, skeletal muscle effects, situational anxiety, and subjective experience of anxious affect. The stress scale is sensitive to levels of chronic non-specific arousal. It assesses difficulty relaxing, nervous arousal, and being easily upset / agitated, irritable / over-reactive and impatient. Scores for depression, anxiety and stress are calculated by summing the scores for the relevant items. Higher scores indicate higher severity of symptoms.

  Screening, baseline, 4 weeks after baseline, 12 weeks after baseline

• Quality of Life by 6-item EQ-5D-5L scale

  The 5-level EQ-5D version (EQ-5D-5L) was introduced by the EuroQol Group in 2009 to improve the instrument's sensitivity and to reduce ceiling effects, as compared to the EQ-5D-3L. The EQ-5D-5L essentially consists of 2 pages: the EQ-5D descriptive system and the EQ visual analogue scale (EQ VAS). The descriptive system comprises five dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. Each dimension has 5 levels: no problems, slight problems, moderate problems, severe problems and extreme problems. The patient is asked to indicate his/her health state by ticking the box next to the most appropriate statement in each of the five dimensions. This decision results in a 1-digit number that expresses the level selected for that dimension. The digits for the five dimensions can be combined into a 5-digit number that describes the patient's health state.

  Baseline, 4 weeks after baseline, 12 weeks after baseline

• Work productivity by WHO-HPQ measure of absenteeism and presenteeism

  Absenteeism questions included both sickness absence and non-sickness absence. The questions asked about the number of days in the past 1 year that participants were absent due to health-related problem and non-health-related conditions separately. The questions about presenteeism asked the number of days in the past 1 year that participants had come to work while sick, felt they should take sick leave or were incapable of working with full performance.

  4 weeks after baseline, 12 weeks after baseline

Secondary Outcomes (6)

• Resilience by 10-item Connor-Davidson Resilience Scale

  Baseline, 4 weeks after baseline, 12 weeks after baseline

• Attitudes, knowledge and behaviours regarding mental health and help-seeking by the Mental Help Seeking Attitudes Scale (MHSAS)

  Baseline, 4 weeks after baseline, 12 weeks after baseline

• Positive psychology by the Cantril Ladder and the WHO-5 Wellbeing Index

  Baseline, 4 weeks after baseline, 12 weeks after baseline

• Emotion regulation by DERS-18

  Baseline, 4 weeks after baseline, 12 weeks after baseline

• Self-reported usage patterns of mindline.sg

  Baseline, during intervention, 4 weeks after baseline, 12 weeks after baseline

Study Arms (2)

Control

NO INTERVENTION

In the control group, participants will receive mental health literacy materials based on standard materials given out in Singapore. At the end-of-study debrief, control group participants will be directed to the mindline.sg website so they can benefit from it.

Intervention

EXPERIMENTAL

In the intervention group, participants will be encouraged to use Mindline.sg for four weeks. Each week, participants will receive a reminder to complete certain activities on the website and a quiz to measure completion of activities.

Behavioral: mindline.sg

Interventions

mindline.sg BEHAVIORAL

mindline.sg is a polydigital mental health platform with resources, wayfinding, and peer support via a forum. The website was built by the MOH Office for Healthcare Transformation together with Ministry of Social and Family Development, National Council of Social Service and Institute of Mental health. The content was cureated by the mindline.sg team and vetted by a clinical review panel which included clinicians from IMH and Fei Yue Community Services.

Intervention

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Aged at least 21 years or at least 18 years old if National of University student
• Have lived in Singapore for at least 2 years
• Have not received a formal diagnosis of a psychiatric disorder
• Not currently receiving any form of mental health treatment (e.g., counselling)
• Fluent in English
• Participants from screening whose DASS-21 scores are mild or moderate for any one of the sub scales.

Sponsors & Collaborators

• Centre for Evidence and Implementation Singapore Ltd: lead
• MOH Office for Healthcare Transformation (MOHT), Singapore: collaborator
• National University of Singapore, Behavioural and Implementation Science Interventions: collaborator

Study Sites (1)

National University of Singapore

Singapore, Singapore

Location

Related Publications (4)

• Saw YE, Tan EY, Liu JS, Liu JC. Predicting Public Uptake of Digital Contact Tracing During the COVID-19 Pandemic: Results From a Nationwide Survey in Singapore. J Med Internet Res. 2021 Feb 3;23(2):e24730. doi: 10.2196/24730.

  PMID: 33465034 BACKGROUND

• Tan EY, Wee RR, Saw YE, Heng KJ, Chin JW, Tong EM, Liu JC. Tracking Private WhatsApp Discourse About COVID-19 in Singapore: Longitudinal Infodemiology Study. J Med Internet Res. 2021 Dec 23;23(12):e34218. doi: 10.2196/34218.

  PMID: 34881720 BACKGROUND

• Barsova T, Cheong ZG, Mak AR, Liu JC. Predicting Psychological Symptoms When Facebook's Digital Well-being Features Are Used: Cross-sectional Survey Study. JMIR Form Res. 2022 Aug 29;6(8):e39387. doi: 10.2196/39387.

  PMID: 36036971 BACKGROUND

• Erdembileg, S., Asplund, C. L., & Liu, J. C. J. (in preparation). Engagement with Taylor Swift's music and social media content predicts mental health outcomes in youths: Cross-sectional survey study.

  BACKGROUND

Study Officials

• Jean Liu, PhD

  National University of Singapore, Yong Loo Lin School of Medicine.

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, CARE PROVIDER
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Director

Model Details: Participants will be randomly assigned to either the control or intervention group. * Control Group: In the control group, participants will receive mental health literacy materials based on standard materials given out in Singapore (e.g., from the Health Promotion Board). * Intervention Group: In the intervention group, participants will be encouraged to use Mindline.sg for four weeks. The intervention includes weekly prompts to engage with different platform features,

Study Record Dates

• First Submitted: September 29, 2025
• First Posted: October 7, 2025
• Study Start: November 20, 2025
• Primary Completion: March 1, 2026
• Study Completion: March 1, 2026
• Last Updated: January 15, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

SG (1)