Healthspan Connect Programme of Research

NCT07209774 | Not Yet Recruiting

• 2 other identifiers: 3624031OT2CA297289-01
• Study Type: observational
• Target: 100,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

Healthspan Connect is a new research programme designed to understand what helps people stay healthy as they age. The programme will explore how lifestyle, environment, genetics, and social factors influence healthy ageing and overall wellbeing. The programme will recruit participants aged 12 years and older across the UK. By including adolescents, the programme aims to understand how early life behaviours and experiences shape long-term health. There is no upper age limit, and people from all backgrounds are encouraged to participate. Special pathways ensure that young participants provide consent in an age-appropriate way. Healthspan Connect is a digital and home-based study, meaning participants can take part from home using smartphones, computers, and online surveys. Participants may also be asked to collect samples such as blood, saliva, stool, urine, or other biological specimens at home using easy-to-use kits. In some sub-studies, participants may be invited to attend research visits for additional tests, scans, or clinical assessments. Family members and close contacts may also be invited to participate in some studies. Through Healthspan Connect, researchers aim to:

• Identify the biological, environmental, and social factors that help people live longer, healthier lives.
• Understand how different groups, including those historically underrepresented in research, experience ageing.
• Explore ways to support behaviour changes that improve health over the lifespan.
• Provide near real-time information to inform health policies and interventions. Participants may also be asked for permission to link their information with health records, education records, and environmental data to better understand health outcomes over time. This programme will serve as a flexible platform for multiple sub-studies, allowing participants to contribute to a wide range of research questions related to healthy ageing, resilience, and long-term health. All data and biological samples will be stored securely and used to advance scientific knowledge, with participant privacy carefully protected.

Conditions

Cancer; Mental Health; Ageing Well; Resilience; Cognitive Health; Psychological Health; Environmental Health Effects; Cardiovascular Health; Metabolic Health; Neurological Health; Musculoskeletal Health; Respiratory Health; Allergies; Eye Health; Other

Keywords

Healthy ageing; Healthspan; Longevity; Ageing resilience; Life course determinants; Multiple long-term conditions; Digital health research; Remote monitoring; Mobile health (mHealth); Wearables; Biobank; Biological specimen collection; Home-based sample collection; Epidemiology; Longitudinal cohort study; Adolescents and ageing; Underrepresented populations in research; Behaviour change; Environmental exposures; Data linkage; Electronic health records (EHR); United Kingdom

Outcome Measures

Primary Outcomes (2)

• Incidence of early-onset colorectal cancer (EOCRC)

  Primary outcome for the first sub-study under the Healthspan Connect programme of research (PROSPECT UK). Defined as a new diagnosis of colorectal cancer before age 50. Confirmed via data from Electronic Health Record Linkage.

  Through study completion, anticipated ≥10 years

• Incidence of early-onset colorectal adenoma (EOCA)

  Primary outcome for the first sub-study under the Healthspan Connect programme of research (PROSPECT UK). Defined as a new diagnosis of colorectal adenoma before age 50. Confirmed via data from Electronic Health Record Linkage.

  Through study completion, anticipated ≥10 years

Eligibility Criteria

• Age: 12 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study will recruit a large, diverse population of UK residents aged 12 years and older, including adolescents, young adults, and adults across the life course. Participants will be drawn from the general population through open digital recruitment methods and will not be limited by specific disease status. The cohort aims to reflect the socioeconomic, geographic, and ethnic diversity of the UK, with particular efforts to include groups typically underrepresented in health research.

You may qualify if:

• Age 12 years or older at time of enrollment.
• Resident in the United Kingdom.
• Able to participate in the study using digital tools (smartphone, tablet, or computer).
• Able to provide informed consent (digital consent accepted).
• For participants aged 12-15 years: must have parent/guardian consent in addition to their own assent.

You may not qualify if:

• Individuals unable to provide informed consent (or parental consent where applicable).
• Individuals not resident in the UK.
• Individuals unable to complete study requirements due to lack of internet access, inability to use digital devices, or severe digital literacy barriers.

Sponsors & Collaborators

• King's College London: lead
• National Cancer Institute (NCI): collaborator
• Cancer Research UK: collaborator
• French National Cancer Institute (Institut National Du Cancer - France): collaborator
• Bowelbabe Fund: collaborator
• Republique Francaise: collaborator

MeSH Terms

Conditions

Neoplasms; Psychological Well-Being; Hypersensitivity

Condition Hierarchy (Ancestors)

Personal Satisfaction; Behavior; Immune System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 26, 2025
• First Posted: October 7, 2025
• Study Start: January 5, 2026
• Primary Completion (Estimated): January 5, 2056
• Study Completion (Estimated): January 5, 2056
• Last Updated: October 7, 2025

Record last verified: 2025-09