Contingency Management for Opioid Use Disorder in Inpatients at Assiut University Hospital
Contingency Management as a Behavioral Intervention for Patients With Opioid Use Disorder : Implementation and Efficacy in the Inpatient Setting at Assiut University Hospital.
1 other identifier
interventional
55
0 countries
N/A
Brief Summary
A scientific study to design and implement a contingency management (CM) program, and to evaluate its effectiveness in promoting abstinence and treatment adherence among individuals with opioid use disorder, as well as to explore its potential for broader implementation in clinical settings.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Dec 2025
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 18, 2025
CompletedFirst Posted
Study publicly available on registry
October 6, 2025
CompletedStudy Start
First participant enrolled
December 1, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
February 1, 2027
October 6, 2025
September 1, 2025
1 year
September 18, 2025
September 27, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Relapse Risk Assessment: Assessed using the Advance Warning of Relapse (AWARE) Questionnaire administered at program entry and exit. Changes in AWARE scores will indicate changes in relapse risk and warning signs.
From baseline (admission) until discharge (~2 weeks), and at 3 months post-discharge
Proportion of opioid-negative urine drug screens during inpatient stay and at 3-month follow-up
From baseline (admission) until discharge (~2 weeks), and at 3 months post-discharge
Study Arms (1)
Contingency Management Intervention
EXPERIMENTALInterventions
Participants with opioid use disorder admitted to the inpatient addiction management unit will receive a contingency management (CM) program as a behavioral intervention. The program consists of providing positive reinforcement (small rewards or incentives) contingent upon objective evidence of desired behaviors, primarily drug abstinence verified by urine toxicology screening. The intervention will be delivered throughout the inpatient stay (approximately two weeks). Participants' adherence and abstinence will be monitored, and rewards will be adjusted based on performance.
Eligibility Criteria
You may qualify if:
- Be 18 years of age or older
- Have a diagnosis of a substance use disorder (SUD) according to DSM-5 criteria
- Be able to understand and provide informed consent
- Be willing to comply with study procedures, including regular drug screening and attendance tracking
- Must be able to swallow tablets
You may not qualify if:
- Have a severe cognitive impairment or active psychosis that interferes with participation
- Currently experiencing a medical condition that would make participation unsafe
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (10)
Rawson RA, Erath TG, Chalk M, Clark HW, McDaid C, Wattenberg SA, Roll JM, McDonell MG, Parent S, Freese TE. Contingency Management for Stimulant Use Disorder: Progress, Challenges, and Recommendations. J Ambul Care Manage. 2023 Apr-Jun 01;46(2):152-159. doi: 10.1097/JAC.0000000000000450. Epub 2023 Feb 3.
PMID: 36745163BACKGROUNDKwon M, Yang S, Park K, Kim DJ. Factors that affect substance users' suicidal behavior: a view from the Addiction Severity Index in Korea. Ann Gen Psychiatry. 2013 Nov 12;12(1):35. doi: 10.1186/1744-859X-12-35.
PMID: 24220264BACKGROUNDPetry NM, Barry D, Alessi SM, Rounsaville BJ, Carroll KM. A randomized trial adapting contingency management targets based on initial abstinence status of cocaine-dependent patients. J Consult Clin Psychol. 2012 Apr;80(2):276-85. doi: 10.1037/a0026883. Epub 2012 Jan 9.
PMID: 22229758BACKGROUNDCoughlin LN, Zhang L, Frost MC, Khazanov G, McKay JR, DePhilippis D, Lin LA. Contingency management for substance use disorders in the U.S. Veterans Health Administration: 2018-2022. J Subst Use Addict Treat. 2024 Aug;163:209400. doi: 10.1016/j.josat.2024.209400. Epub 2024 May 11.
PMID: 38735480BACKGROUNDMcDonell MG, Skalisky J, Burduli E, Foote A Sr, Granbois A, Smoker K, Hirchak K, Herron J, Ries RK, Echo-Hawk A, Barbosa-Leiker C, Buchwald D, Roll J, McPherson SM. The rewarding recovery study: a randomized controlled trial of incentives for alcohol and drug abstinence with a rural American Indian community. Addiction. 2021 Jun;116(6):1569-1579. doi: 10.1111/add.15349. Epub 2021 Jan 14.
PMID: 33220122BACKGROUNDPetry NM, Tedford J, Austin M, Nich C, Carroll KM, Rounsaville BJ. Prize reinforcement contingency management for treating cocaine users: how low can we go, and with whom? Addiction. 2004 Mar;99(3):349-60. doi: 10.1111/j.1360-0443.2003.00642.x.
PMID: 14982548BACKGROUNDDennis M, Scott CK. Managing addiction as a chronic condition. Addict Sci Clin Pract. 2007 Dec;4(1):45-55. doi: 10.1151/ascp074145.
PMID: 18292710BACKGROUNDSussman S, Sussman AN. Considering the definition of addiction. Int J Environ Res Public Health. 2011 Oct;8(10):4025-38. doi: 10.3390/ijerph8104025. Epub 2011 Oct 20.
PMID: 22073026BACKGROUNDHofer D, Wenger F, Kohler M, Badertscher M. [Addiction in psychiatric ambulatory service]. Ther Umsch. 2014 Oct;71(10):609-16. doi: 10.1024/0040-5930/a000600. German.
PMID: 25257115BACKGROUNDGBD 2016 Alcohol and Drug Use Collaborators. The global burden of disease attributable to alcohol and drug use in 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Psychiatry. 2018 Dec;5(12):987-1012. doi: 10.1016/S2215-0366(18)30337-7. Epub 2018 Nov 1.
PMID: 30392731BACKGROUND
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Resident doctor
Study Record Dates
First Submitted
September 18, 2025
First Posted
October 6, 2025
Study Start
December 1, 2025
Primary Completion (Estimated)
December 1, 2026
Study Completion (Estimated)
February 1, 2027
Last Updated
October 6, 2025
Record last verified: 2025-09