Tianshan Community Cohort Establishment and Follow-up

NCT07207863 | Recruiting DMC

• 1 other identifier: Tianshan2025
• Study Type: observational
• Target: 1,000,000
• Locations: 1 country
• Sites: 1

Brief Summary

This population-based cohort study on disease prevention and health promotion was established in northwest China, leveraging data from routine annual health examinations. Initiated in January 2016, the cohort enrolled nearly all residents aged 18 years and older who were registered at community healthcare centers. The program was developed to provide a comprehensive framework for disease prevention and community health promotion, with the aim of producing population-based evidence across a broad spectrum of diseases in the general population. At baseline, data were collected on participant demographics, medical and family histories, disability status, living environment, and blood biochemical parameters. Follow-up information is primarily obtained through chronic disease management programs, annual health examinations, and electrical health records. Cause-specific mortality is ascertained from local death registration systems. Biological specimens, questionnaire data, and electrical health records are systematically archived in the Biobank and Big Data Center of the People's Hospital of Xinjiang Uygur Autonomous Region.

Conditions

Cohort Study; Natural Population; Northwest Region of China

Outcome Measures

Primary Outcomes (16)

• Mortality

  All-cause and cause-specific mortality during follow-up

  20 years

• Cardiovascular diseases

  Incident disease during follow-up

  20 years

• Digestive diseases

  Incident disease during follow-up

  20 years

• Endocrine diseases

  Incident disease during follow-up

  20 years

• Infections diseases

  Incident disease during follow-up

  20 years

• Benign neoplasm or Carcinoma in situ

  Incident disease during follow-up

  20 years

• Cancers

  Incident disease during follow-up

  20 years

• Genitourinary diseases

  Incident disease during follow-up

  20 years

• Haematological or immunological diseases

  Incident disease during follow-up

  20 years

• Musculoskeletal diseases

  Incident disease during follow-up

  20 years

• Neurological diseases

  Incident disease during follow-up

  20 years

• Psychiatric diseases

  Incident disease during follow-up

  20 years

• Respiratory diseases

  Incident disease during follow-up

  20 years

• Ocular diseases

  Incident disease during follow-up

  20 years

• Dermatological diseases

  Incident disease during follow-up

  20 years

• Ear and mastoid disorders

  Incident disease during follow-up

  20 years

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Eligible residents from routine annual health examinations.

You may qualify if:

• Residents \>=18y
• Permanent residents or individuals who have lived in the region for more than 5 years and are enrolled in local social security medical insurance
• Residents without severe physical disability and capable of normal communication
• Residents whose diseases and deaths are monitored and managed by the local health authorities
• Residents who voluntarily participate and provide written informed consent

You may not qualify if:

• Temporary residents or floating population
• Residents with severe health conditions that prevent participation in the study
• Residents who are unwilling to undergo follow-up assessments for the study

Sponsors & Collaborators

• People's Hospital of Xinjiang Uygur Autonomous Region: lead
• People's Hospital of Hotan Prefecture: collaborator
• People's Hospital of Altay Prefecture: collaborator
• Luopu County People's Hospital of Hotan Prefecture: collaborator
• The First People's Hospital of Aksu Prefecture: collaborator
• Karamay Central Hospital of Xinjiang: collaborator
• People's Hospital of Kizilsu Kyrgyz Autonomous Prefecture: collaborator
• The Second People's Hospital of Kashgar Prefecture: collaborator
• RenJi Hospital: collaborator

Study Sites (1)

People's Hospital of Xinjiang Uygur Autonomous Region

Ürümqi, Xinjiang, 830001, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

During routine health checkups, 10 mL of EDTA-anticoagulated blood, 10 mL of urine, 10 g of feces and 2 mL of saliva are collected. Samples are transported to the Biobank of the People's Hospital of Xinjiang Uygur Autonomous Region for processing within 2 hours and subsequently stored at -80 °C in an ultra-low temperature freezer.

Study Officials

• Yining Yang, Prof.

  People's Hospital of Xinjiang Uygur Autonomous Region

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Qian Zhao, Dr.

CONTACT

+86-13899993630; tina0627@126.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.

Study Record Dates

• First Submitted: September 27, 2025
• First Posted: October 6, 2025
• Study Start: January 1, 2016
• Primary Completion (Estimated): December 31, 2035
• Study Completion (Estimated): December 31, 2035
• Last Updated: October 6, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)