Cephalic Phase Responses to Nutritive and Non-Nutritive Sweeteners
1 other identifier
interventional
30
1 country
1
Brief Summary
This study will focus on changes in blood sugar in response to tasting different types of sweeteners using continuous glucose monitoring (CGM) technology.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Mar 2024
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 26, 2024
CompletedFirst Submitted
Initial submission to the registry
March 27, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 17, 2024
CompletedFirst Posted
Study publicly available on registry
April 29, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
March 30, 2025
CompletedApril 29, 2024
April 1, 2024
22 days
March 27, 2024
April 24, 2024
Conditions
Outcome Measures
Primary Outcomes (1)
Blood glucose concentration
blood glucose concentration measured by continuous glucose monitoring
10 days
Study Arms (5)
No Oral Stimulation
OTHERNo oral stimulation is provided.
Oral Water Stimulation
OTHEROral stimulation with water.
Oral Salt Stimulation
OTHEROral stimulation with salt.
Oral Sucralose Stimulation
OTHEROral stimulation with sucralose.
Oral Sucrose stimulation
OTHEROral stimulation with sucrose.
Interventions
Eligibility Criteria
You may qualify if:
- Adults aged between 18 to 70 years old will be eligible to participate.
- Good health and without known medical conditions, including but not limited to, diabetes, cardiovascular diseases, metabolic disorders, and any other chronic conditions that could significantly affect glycemia.
- No history of major surgeries, organ transplantations, or significant medical interventions that might impact glycemia.
- No medications that could interfere with glucose metabolism or sweet taste perception. Use of vitamins or contraceptives will be permissible if continued for the 12 days of study participation.
- No dietary restrictions or sensitivities that prevent them from tasting or swishing sweeteners and rice cakes provided during the study.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Purdue University
West Lafayette, Indiana, 47907, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Richard Mattes, PhD
Purdue University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Masking Details
- solutions are coded
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Distinguished Professor
Study Record Dates
First Submitted
March 27, 2024
First Posted
April 29, 2024
Study Start
March 26, 2024
Primary Completion
April 17, 2024
Study Completion
March 30, 2025
Last Updated
April 29, 2024
Record last verified: 2024-04
Data Sharing
- IPD Sharing
- Will not share