People & Place: Impacts on Substance Use and HIV Outcomes in Los Angeles

NCT07200973 | Not Yet Recruiting

• 1 other identifier: 5R01DA061345
• Study Type: interventional
• Target: 250
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study will implement an adapted peer navigation intervention to improve linkage to and retention in HIV care for people living with HIV who experience substance use within Los Angeles County.

Conditions

HIV

Outcome Measures

Primary Outcomes (2)

• Number of Participants with HIV Viral Suppression

  Measured via HIV Viral Load (copies/mL)

  From enrollment to the end of intervention period at 24 weeks

• Number of Participants with HIV Care Adherence

  Participants' engagement in their HIV care, defined by attendance at scheduled HIV medical appointments

  From enrollment to the end of intervention period at 24 weeks

Secondary Outcomes (2)

• Number of Participants with HIV Antiretroviral (ART) Adherence

  From enrollment to the end of intervention period at 24 weeks

• Number of Participants with Recent Substance Use

  From enrollment to the end of intervention period at 24 weeks

Study Arms (1)

Adapted LINK-LA Peer Case Management

EXPERIMENTAL

LINK-LA Peer Case Management Intervention, adapted for people living with HIV who use substances

Behavioral: Adapted LINK LA Peer Navigator

Interventions

Adapted LINK LA Peer Navigator BEHAVIORAL

Our study will adapt the LINK LA peer navigation intervention (NCT01406626) for the current context (e.g., HIV care provision, substance use risk environments, etc.) and measure its effects on participants' HIV and substance care engagement.

Adapted LINK-LA Peer Case Management

Eligibility Criteria

• Age: 18 Years+
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Living with HIV
• Assigned male sex at birth
• Willing to return for follow-up study visits every six months as long as the study is ongoing and be available to return for all study visits, barring unforeseen circumstances
• Willing and able to provide written informed consent to take part in the study
• Willing and able to provide adequate information for locator purposes
• Willing to undergo repeat HIV viral load testing at select study visits
• Willing to undergo substance use testing at each study visit

You may not qualify if:

• Born biologically female
• Unwilling or unable to provide reliable contact information
• Unwilling to provide urine or blood
• Any other condition or prior therapy that, in the opinion of the research staff would preclude informed consent, make study participation unsafe, make the individual unsuitable for the study or unable to comply with the study requirements. Such conditions may include, but are not limited to, renal, hepatic, hematological, gastrointestinal, endocrine, pulmonary, neurological, or cerebral disease, among others

Sponsors & Collaborators

• University of California, Los Angeles: lead

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 23, 2025
• First Posted: October 1, 2025
• Study Start: May 1, 2026
• Primary Completion (Estimated): October 1, 2028
• Study Completion (Estimated): October 1, 2028
• Last Updated: October 6, 2025

Record last verified: 2025-09