NCT05967208

Brief Summary

Despite worldwide efforts to promote HIV testing, rates of testing remain low. The purpose of this study is to evaluate the acceptability, efficacy, and cost-effectiveness of confidential SMS-based social network referrals for HIV testing as a means of reaching high-risk individuals and prompting them to test for HIV. To accomplish this purpose, the study has 5 specific aims: Aim 1 will conduct qualitative, formative work to identify desirable provider- and client-side characteristics of a confidential SMS-based HIV testing referral system. Aim 2 will adapt an existing mHealth system (mParis) to add CONSORT functionality. Aim 3 will pilot-test the CONSORT system to collect preliminary data on the system's acceptability, performance, and potential efficacy. Aim 4 will evaluate the acceptability and efficacy of CONSORT in a randomized controlled trial. Aim 5 will evaluate the incremental cost-effectiveness of CONSORT vs. other referral options. If CONSORT is shown to be acceptable, effective, and cost-effective, such mobile-phone supported, chain-referral methods could greatly improve the cost-effectiveness of HIV testing efforts.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
600

participants targeted

Target at P75+ for not_applicable hiv

Timeline
11mo left

Started May 2025

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress53%
May 2025Apr 2027

First Submitted

Initial submission to the registry

January 26, 2023

Completed
6 months until next milestone

First Posted

Study publicly available on registry

August 1, 2023

Completed
1.8 years until next milestone

Study Start

First participant enrolled

May 1, 2025

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2026

Expected
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2027

Last Updated

August 1, 2023

Status Verified

July 1, 2023

Enrollment Period

1.4 years

First QC Date

January 26, 2023

Last Update Submit

July 25, 2023

Conditions

Outcome Measures

Primary Outcomes (1)

  • Uptake of HIV testing

    The number of referred clients presenting for HIV testing at participating study sites within 30 days of the testing offer, per 100 index clients.

    Within 30 days of the time of the testing offer

Study Arms (2)

CONSORT referrals + Card referrals

EXPERIMENTAL

Intervention arm

Behavioral: CONSORT referralsBehavioral: Card referrals

Card referrals alone

ACTIVE COMPARATOR

Control arm

Behavioral: Card referrals

Interventions

Participants will be offered SMS-based confidential social network referrals for HIV testing ("CONSORT referrals") to extend to any of their social and sexual network contacts.

CONSORT referrals + Card referrals
Card referralsBEHAVIORAL

Participants will be offered physical invitation cards ("card referrals") to extend to any of their social and sexual network contacts.

CONSORT referrals + Card referralsCard referrals alone

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • at least 18 years old
  • live, work, or regularly receive care in Moshi, Tanzania
  • literate

You may not qualify if:

  • under age 18 years
  • does not live, work, or regularly receive care in Moshi, Tanzania
  • illiterate

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (2)

  • Ostermann J, Njau B, Masaki M, Mtuy T, Itemba D, Hobbie A, Yelverton V, Moore S, Yamanis T, Thielman NM. Feasibility, Acceptability, and Potential Cost-Effectiveness of a Novel Mobile Phone Intervention to Promote Human Immunodeficiency Virus Testing Within Social Networks in Tanzania. Sex Transm Dis. 2022 Nov 1;49(11):778-781. doi: 10.1097/OLQ.0000000000001611. Epub 2022 Jan 29.

    PMID: 35093981BACKGROUND
  • Ostermann J, Njau B, van Zwetselaar M, Yamanis T, McClimans L, Mwangi R, Beti M, Hobbie A, Gass SJ, Mtuy T, Thielman N. Mobile Phone-Based Confidential Social Network Referrals for HIV Testing (CONSORT): Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2024 May 30;13:e55068. doi: 10.2196/55068.

Study Officials

  • Jan Ostermann, PhD

    University of South Carolina

    PRINCIPAL INVESTIGATOR
  • Nathan Thielman, MD

    Duke University

    PRINCIPAL INVESTIGATOR
  • Bernard Njau, PhD

    Kilimanjaro Christian Medical Centre, Tanzania

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Jan Ostermann, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

January 26, 2023

First Posted

August 1, 2023

Study Start

May 1, 2025

Primary Completion (Estimated)

October 1, 2026

Study Completion (Estimated)

April 1, 2027

Last Updated

August 1, 2023

Record last verified: 2023-07

Data Sharing

IPD Sharing
Will share

All investigators are committed to managing and distributing original data and results to enable subsequent availability to the scientific community, policy makers, and other stakeholders. Final research data including metadata and descriptors may be made available after publication of study findings through a CONSORT data repository. Researchers may access data by request to the Principal Investigators. Access will be provided subject to Tanzanian and US rules, laws, regulations and policies and consistent with institutional review board approvals and consent documents. If conditions prevent making some data elements available (e.g., third party data), relevant publications and presentations will be provided.

Shared Documents
STUDY PROTOCOL, SAP, ANALYTIC CODE
Time Frame
After publication of study findings
Access Criteria
Access will be provided subject to Tanzanian and US rules, laws, regulations and policies and consistent with institutional review board approvals and consent documents. If conditions prevent making some data elements available (e.g., third party data), relevant publications and presentations will be provided.