Comparison of Mean Duration of Post Operative Analgesia Following QL-2 Block vs QL-3 Block Using Ropivacain 0.25% in Patients Undergoing Unilateral Inguinal Hernia Repair

NCT07200076 | Completed DMC

• 1 other identifier: BVH-2025-CT-010
• Study Type: interventional
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

To compare the mean dulation of post operative analgesia following QL2 block (posterior quadratus lumborum block) and the QL3 block (transmuscular quadratus lumborum block) using ropivacaine 0.25% in patients undergoing unilateral inguinai hernia repair. Rationale of the proposed study is to find an optimal approach for quadratus lumborum block (QLB) in the context of local population as no local study has already been carried out for our population. The study seeks to determine which approach provides superior postoperative pain relief and aspires to establish a clear rationale for the application of one technique over the other in local population. By uncovering the strengths and limitations of each approach, the study intends to guide local clinicians in making informed decisions for optimizing postoperative pain management strategies. The outcomes of this study are anticipated to have a substantial impact on clinical practice, potentially leading to improved patient outcomes, reduced opioid consumption, and enhanced patient comfort following inguinal hernia repair surgeries in local settings.

Conditions

Inguinal Hernia Unilateral

Outcome Measures

Primary Outcomes (2)

• Change in systolic Blood pressure

  Baseline, 30 minutes, 2 hours, 4 hours, 8 hours, 12 hours 24 hours

• Mean duration of analgesia

  assessed using the Visual Analog Score (VAS) ranging tiom 0-10 (0= no pain, l0= the most severe unbearable pain)

  Baseline, 30 minutes, 2 hours, 4 hours, 8 hours, 12 hours, 24 hours

Study Arms (2)

QLB-2 (posterior QL block) Group

ACTIVE COMPARATOR

Procedure: Quadratus Lumborum (QL) Block

QLB-3 (transmuscular QL block) Group

ACTIVE COMPARATOR

Procedure: Quadratus Lumborum (QL) Block

Interventions

Quadratus Lumborum (QL) Block PROCEDURE

In the QLB-2 approach, a needle will be inserted in-plane from anterior to posterior, directed towards the posterior QL muscle border, and a 20 ml solution of 0.25% ropivacaine will be injected. For the QLB-3 approach, the needle will be inserted in-plane from anterior to posterior, traversing the QL muscle's proper fascia to target the plane between the QL and PM muscles, and a 20 ml solution of 0.25% ropivacaine will be injected.

QLB-2 (posterior QL block) Group; QLB-3 (transmuscular QL block) Group

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age between 18 and 50 years ASA status 1 or 2 Scheduled for unilateral inguinal hernia repair under General Anaesthesia

You may not qualify if:

• Patient refusal Patients with pre-existing coagulation abnormalities INR more thnn 1.5 Patients with Strangulated hernia Hypersensitivity to local anaestiretics. Local infection at procedure sito.

Sponsors & Collaborators

• Quaid-e-Azam Medical College: lead

Study Sites (1)

Bahawal Victoria Hospital, Bahawalpur

Bahawalpur, Punjab Province, 63100, Pakistan

Location

MeSH Terms

Interventions

Dental Occlusion

Intervention Hierarchy (Ancestors)

Dentistry; Dental Physiological Phenomena; Digestive System and Oral Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: September 22, 2025
• First Posted: September 30, 2025
• Study Start: July 1, 2024
• Primary Completion: December 30, 2024
• Study Completion: January 28, 2025
• Last Updated: October 6, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)