A Prospective, Randomized, Double-blind Study on the Effects of Different Anesthesia Strategies on Postoperative Cough in Patients Undergoing Video-assisted Thoracoscopic Surgery.

NCT07190664 | Not Yet Recruiting

• 1 other identifier: 2025KY282
• Study Type: interventional
• Target: 228
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to systematically evaluate the effects of different anesthesia methods on postoperative chronic cough in lung cancer patients undergoing video-assisted thoracoscopic lung resection (VATS), and to clarify the effectiveness and safety of each anesthesia airway management strategy in reducing the incidence of postoperative chronic cough, shortening the duration of cough, alleviating the severity of symptoms, and improving the postoperative quality of life of patients.

Conditions

Chronic Cough; Video-assisted Thoracoscopic Surgery (VATS)

Keywords

Video-assisted thoracoscopic surgery; chronic cough

Outcome Measures

Primary Outcomes (1)

• The incidence of postoperative chronic cough, cough duration and cough severity score were recorded

  The perioperative follow-up time points were 1 day, 2 days, 3 days, 7 days, 14 days and 1 month after operation. The follow-up time points of postoperative chronic phase were set at 3 months, 6 months and 12 months after operation.

  The perioperative follow-up time points were 1 day, 2 days, 3 days, 7 days, 14 days and 1 month after operation. The follow-up time points of postoperative chronic phase were set at 3 months, 6 months and 12 months after operation.

Study Arms (3)

Single-lumen endotracheal intubation group

ACTIVE COMPARATOR

During the process of general anesthesia, a single-lumen endotracheal tube combined with a bronchial blocker was used to perform pulmonary isolation surgery, thereby meeting the requirements of video-assisted thoracoscopic partial lung resection.sample size:76

Other: Patients were randomly grouped

Double-lumen endotracheal tube group

ACTIVE COMPARATOR

During the general anesthesia process, a double-lumen endotracheal tube was used for lung isolation surgery, thus meeting the requirements of video-assisted thoracoscopic partial lung resection.sample size:76

Other: Patients were randomly grouped

Laryngeal mask group

EXPERIMENTAL

During the general anesthesia procedure, a laryngeal mask was used, and the patient maintained spontaneous breathing for the thoracoscopic partial lung resection surgery.sample size:76

Other: Patients were randomly grouped

Interventions

Patients were randomly grouped OTHER

All patients included in the study, were randomized

Double-lumen endotracheal tube group; Laryngeal mask group; Single-lumen endotracheal intubation group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• planned wedge resection, segmentectomy or lobectomy;
• more than 18 years old;
• American Society of Anesthesiologists (ASA) grade ≤Ⅲ;
• body mass index (BMI) ≤24 kg/m2;
• Normal pulmonary function, predicted forced expiratory volume in 1 second (FEV1%) \>50%, resting blood gas analysis showed arterial partial pressure of oxygen (PaO2) ≥75 mmHg and arterial partial pressure of carbon dioxide (PaCO2) \<45 MMHG;
• Normal cardiac function with ejection fraction (EF) \> 50% of predicted value;
• Informed consent and signed informed consent form.

You may not qualify if:

• (1) patients who refuse surgery and/or anesthesia; (2) preoperative pulmonary infection; (3) previous history of ipsilateral surgery or other medical history that may cause extensive pleural adhesions; (4) phrenic nerve palsy on the non-operative side; (5) patients with high risk of preoperative reflux (fasting \<6 hours) or gastroesophageal reflux disease; (6) patients with heart, kidney, liver and other organ dysfunction and surgical contraindications; (7) with severe cognitive, psychological and communication disorders.

Sponsors & Collaborators

• Fujian Medical University Union Hospital: lead

MeSH Terms

Conditions

Chronic Cough

Condition Hierarchy (Ancestors)

Cough; Respiration Disorders; Respiratory Tract Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 17, 2025
• First Posted: September 24, 2025
• Study Start: October 1, 2025
• Primary Completion: December 1, 2025
• Study Completion: December 30, 2025
• Last Updated: September 24, 2025

Record last verified: 2025-06