Efficacy of Behavioral Therapy for Chronic Refractory Cough

NCT07488598 | Recruiting DMC

• 1 other identifier: Chronic Refractory Cough
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Chronic cough is defined as cough persisting for more than eight weeks. It is a common clinical problem that significantly impairs patients' physical, psychological, and social quality of life. Chronic cough remains a diagnostic and therapeutic challenge despite systematic evaluation and treatment of common etiologies such as asthma, gastroesophageal reflux disease

Conditions

Chronic Cough

Outcome Measures

Primary Outcomes (1)

• Treatment of Chronic Cough

  The patient's subjective response to treatment, categorized as: resolved, improved, no change, or worse. it will be assisted by Cough-Specific Quality of Life: Leicester Cough Questionnaire (LCQ): The primary measure of cough-specific health-related quality of life (QoL). and also assesses physical, psychological, and social domains

  6 months

Study Arms (1)

Behavioral Therapy for chronic cough

EXPERIMENTAL

About 30 patients suffering from chronic cough persisting for more than eight weeks that is refractory to standard medical treatment for common causes of chronic cough, including asthma, gastroesophageal reflux disease

Behavioral: Behavioral Therapy

Interventions

Behavioral Therapy BEHAVIORAL

to evaluate the efficacy of behavioral therapy for chronic cough in patients with laryngeal hyperresponsiveness in order to assess its role as a non-pharmacological management strategy. This will provide an efficient plan of therapy for such challenging condition.

Also known as: Laryngeal hyperresponsiveness

Behavioral Therapy for chronic cough

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Eligible participants are adults aged ≥18 years i.e. normal chest radiograph.
• participants with chronic cough persisting for more than eight weeks that is refractory to standard medical treatment for common causes of chronic cough, including asthma, gastroesophageal reflux disease .
• Participants are required to exhibit clinical features suggestive of laryngeal hyperresponsiveness, such as cough triggered by phonation, laughter, cold air, or irritant exposure, with associated laryngeal symptoms including throat irritation, dysphonia, or frequent throat clearing.

You may not qualify if:

• Patients are excluded if they are current smokers or had ceased smoking within six months
• patients have evidence of active pulmonary or cardiac disease, recent respiratory tract infection, recent angiotensin-converting enzyme inhibitor use.
• significant structural laryngeal pathology, neurological disorders affecting cough reflex control, or inability to comply with study procedures.
• Head \&neck pathology e.g sinusitis, glottal insufficiency or primary muscle tension dysphonia

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assuit University hospitals

Asyut, Egypt

RECRUITING

MeSH Terms

Conditions

Chronic Cough

Interventions

Behavior Therapy

Condition Hierarchy (Ancestors)

Cough; Respiration Disorders; Respiratory Tract Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Psychotherapy; Behavioral Disciplines and Activities

Study Officials

• Eman Sayed Hassan, Professor

  Head of Phoniatric unit,ENT Department,Faculty of Medicine, Assiut University

  STUDY CHAIR

Central Study Contacts

Mohamed Shaaban Mohamed Mahfouz, Resident

CONTACT

+201094817965; mhamedshaaban6@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident at of Phoniatric, ENT Department,Faculty of Medicine

Study Record Dates

• First Submitted: March 18, 2026
• First Posted: March 23, 2026
• Study Start: March 10, 2026
• Primary Completion (Estimated): March 1, 2027
• Study Completion (Estimated): May 10, 2027
• Last Updated: April 23, 2026

Record last verified: 2026-03

Locations

EG (1)