Impulse Oscillometry in COPD Exacerbation

NCT07185581 | Completed

• 1 other identifier: 20.12.2023; 2023/0971
• Study Type: observational
• Target: 41
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to evaluate small airway function during ECOPD and recovery periods using IOS. In this prospective single-center study, patients with ECOPD underwent evaluation of their pulmonary functions using IOS and spirometry during exacerbation and recovery (6-12 weeks after exacerbation). The patients were divided into two groups: mild exacerbations and (moderate and severe) exacerbations based on ROME criteria.A total of 41 patients were initially enrolled, with 38 completing the study. This study reveals that IOS can be easily used in ECOPD, and IOS parameters that reflect small airways (R5-R20, AX, and Fres) are correlated with FEV1% and the severity of dyspnea. Additionally, IOS parameters significantly improve during recovery, except for R20. Further research is necessary on its application in the functional assessment of patients with COPD exacerbations.

Conditions

COPD Exacerbation; COPD

Keywords

copd; exacerbation; ios; small airway

Outcome Measures

Primary Outcomes (1)

• Physiological parameter of IOS in COPD exacerbation period

  We investigated descriptive parameters of impulse oscillometry during copd exacerbation period to use in clinical setting in the future. The parameters for assessing airway resistance, including resistance at 5 Hz (R5), which indicates total airway resistance; resistance at 20 Hz (R20), representing the resistance of large airways; and the difference between resistance at 5 Hz and 20 Hz ( R5-R20 ). The parameters that assess reactance are X5, which measures peripheral elastic resistance at 5 Hz; AX, the area under the reactance curve between 5 Hz and the resonant frequency, reflecting the elastic properties of the lung; and Fres, the oscillation frequency at which reactance is zero. In the exacerbation of copd period FEV1% was correlated with all IOS parameters except R20, and BORG was correlated with IOS parameters except R20 and X5. Furthermore, IOS parameters reflecting the small airways (R5-R20, X5, AX, Fres) also showed strong intercorrelations.

  from baseline

Secondary Outcomes (2)

• Comparison of parameter of IOS in COPD exacerbation period to stable period (approximately 6 weeks later)

  6 weeks later from the baseline

• Comparison and correlations of IOS and pulmonary function test parameters in recovery period of COPD patient

  6 weeks later from the baseline

Study Arms (2)

mild exacerbations

Patients were divided into two groups: mild exacerbations (group 1) and moderate and severe exacerbations (group 2) based on ROME criteria.

Diagnostic Test: Impulse Oscillometry

moderate and severe exacerbations

Patients were divided into two groups: mild exacerbations (group 1) and moderate and severe exacerbations (group 2) based on ROME criteria.

Diagnostic Test: Impulse Oscillometry

Interventions

Impulse Oscillometry DIAGNOSTIC_TEST

Impulse Oscillometry (IOS) is a simple, non-invasive, effort-independent method that uses sound waves to detect airway changes quickly. It only requires the patient to breathe normally to assess lung function by measuring both resistance and reactance of the airways. 6,7 These features of IOS suggest it may be a useful test for assessing patient respiratory function during exacerbation periods when airway resistance, airflow limitation, and respiratory muscle weakness further impair breathing.

Also known as: ios

mild exacerbations; moderate and severe exacerbations

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

41 patients who were consecutively admitted to the emergency department or pulmonology outpatient clinic of our hospital with a diagnosis of ECOPD, as defined by the GOLD 2023 Report 1 , were enrolled in the study.

You may qualify if:

• patients who were consecutively admitted to the emergency department or pulmonology outpatient clinic of our hospital with a diagnosis of ECOPD, as defined by the GOLD 2023 Report

You may not qualify if:

• Patients diagnosed with pneumonia, pulmonary embolism, heart failure, pleural effusion, or pneumothorax were excluded.
• Patients who were unable to perform spirometry during exacerbation or had a forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) ratio of ≥ 0.70 were also excluded.

Sponsors & Collaborators

• Deniz Bilici: lead

Study Sites (1)

Istanbul Medeniyet University

Istanbul, Turkey (Türkiye)

Location

Related Publications (32)

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  RESULT

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  RESULT

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Esma Seda Akalın, MD

  Istanbul Medeniyet University

  PRINCIPAL INVESTIGATOR

• Deniz Koçak, Research Assistant

  Istanbul Medeniyet University

  PRINCIPAL INVESTIGATOR

• Elif Hazal Karadağ, Research Assistant

  Istanbul Medeniyet University

  PRINCIPAL INVESTIGATOR

• Burcu Arpınar Yiğitbaş, Associate professor:

  Istanbul Medeniyet University

  PRINCIPAL INVESTIGATOR

• Deniz Bilici, MD

  Istanbul Medeniyet University

  PRINCIPAL INVESTIGATOR

• Handan Ankaralı, Professor

  Istanbul Medeniyet University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 6 Weeks
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: md

Study Record Dates

• First Submitted: September 4, 2025
• First Posted: September 22, 2025
• Study Start: March 1, 2024
• Primary Completion: September 30, 2024
• Study Completion: September 30, 2024
• Last Updated: September 22, 2025

Record last verified: 2025-09

Locations

TU (1)