This Hospital-based Observational Study Employed a Study Will be Conducted in Sohag University Hospital Clinics Aiming to Ensure Cases Presented With Psychosis in Two Phases to Differentiate Into Two Groups a Case of Schizophrenia or a Case of Methamphetamine Induced Psychosis.

NCT07184710 | Not Yet Recruiting

• 1 other identifier: soh-Med--25-8-3MS
• Study Type: observational
• Target: 200
• Locations: 0 countries
• Sites: N/A

Brief Summary

This hospital-based observational study employed prospective follow up study will be conducted in sohag university hospital clinics aiming to ensure cases presented with psychosis in two phases to differentiate into 2 groups (a case of schizophrenia or a case of METH induced psychosis) Phases-1 includes:

• the need of hospitalization and its duration
• time of recovery
• job dysfunction duration

Conditions

Comparing Clinical Profile and Prognosis of Schizophrenia Versus Methamphetamine Induced Psychosis; SCHIZOPHRENIA; Methamphetamine Induced Psychosis

Keywords

psychosis; schizophrenia; METH; comparative

Outcome Measures

Primary Outcomes (1)

• severity of symptoms of psychosis at time of presentation

  using positive and negative syndrome scale of schizophrenia Positive scale 7 Items, (minimum score = 7, maximum score = 49) includes : Delusions Conceptual disorganization Hallucinations Excitement Grandiosity Suspiciousness/persecution Hostility Negative scale 7 Items, (minimum score = 7, maximum score = 49) includes : Blunted affect Emotional withdrawal Poor rapport Passive/apathetic social withdrawal Difficulty in abstract thinking Lack of spontaneity and flow of conversation Stereotyped thinking General Psychopathology scale 16 Items, (minimum score = 16, maximum score = 112) includes : Somatic concern Anxiety Guilt feelings Tension Mannerisms and posturing Depression Motor retardation Uncooperativeness Unusual thought content Disorientation Poor attention Lack of judgment and insight Disturbance of volition Poor impulse control Preoccupation Active social avoidance PANSS Total score minimum = 30, maximum = 210

  from enrollment to 3 Months

Secondary Outcomes (1)

• improvement after treatment and/or hospitalization

  after 3 months of first visit.

Study Arms (2)

schizophrenia

METH induced psychosis

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The sample thus comprised all available patients with methamphetamine-related psychosis or schizophrenia attending the clinic during the study period.

You may not qualify if:

• included presence of primary neurological disorders (e.g., epilepsy, dementia), significant medical illness affecting cognition, or inability to participate in interviews.

Sponsors & Collaborators

• Sohag University: lead

MeSH Terms

Conditions

Schizophrenia; Psychotic Disorders

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Study Officials

• Taher abdelrhim Sayed, Prof.

  faculy of medicine_ sohag university

  STUDY CHAIR

• osama abdelraouf Morad, Ph.D

  faculy of medicine_ sohag university

  STUDY CHAIR

• osama eltaher mahmoud, Ph.D

  faculy of medicine_ sohag university

  STUDY CHAIR

Central Study Contacts

ali alaaeldeen kenawy, M.B.B.Ch

CONTACT

+20; ali.alaaeldeen@med.sohag.edu.eg

osama eltaher mahmoud, Ph.D

CONTACT

+20

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.B.B.Ch resident in neurology and psychological medicine department sohag university

Study Record Dates

• First Submitted: September 2, 2025
• First Posted: September 22, 2025
• Study Start: October 24, 2025
• Primary Completion (Estimated): August 25, 2026
• Study Completion (Estimated): August 25, 2026
• Last Updated: October 2, 2025

Record last verified: 2025-09