NCT07183072

Brief Summary

Physical functionality and performance are important for individuals diagnosed with scleroderma. There is a need to address children and adults diagnosed with scleroderma comprehensively and to evaluate them on a biopsychosocial basis to support their disease management. In light of all this literature, the aim was to evaluate the biopsychosocial characteristics of both pediatric and adult scleroderma patients and to examine their physical performance and functionality. Additionally, this study aims to identify effective tests that can be used in future research to assess physical performance and functionality in individuals diagnosed with scleroderma.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for all trials

Timeline
15mo left

Started Aug 2025

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress38%
Aug 2025Aug 2027

Study Start

First participant enrolled

August 4, 2025

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

September 13, 2025

Completed
6 days until next milestone

First Posted

Study publicly available on registry

September 19, 2025

Completed
1.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2027

Expected
3 days until next milestone

Study Completion

Last participant's last visit for all outcomes

August 4, 2027

Last Updated

September 19, 2025

Status Verified

August 1, 2025

Enrollment Period

2 years

First QC Date

September 13, 2025

Last Update Submit

September 13, 2025

Conditions

Keywords

Juvenile sclerodermasclerodermasystemic sclerosisphysical performancefunctionality

Outcome Measures

Primary Outcomes (6)

  • 6-Minute Walk Test

    Participants are asked to walk as quickly as they can along a 30-meter corridor. The total distance will be measured in meters. Fatigue, pain and dyspnea will be monitored using the Modified Borg Scale.

    Two weeks

  • Timed Up and Go Test

    The time it takes for a person to get up from a chair with back support, walk 3 meters at a normal pace, and return to the chair is measured in seconds to evaluate lower extremity balance. The test will be performed 3 times.

    Two weeks

  • 10-Step Stair Climbing Test

    To assess the subject's lower extremity strength and dynamic balance, the time taken to quickly climb and descend a staircase with 10 steps, each measuring 16-20 cm high and equipped with a handrail, is recorded in seconds. The test is repeated three times, and the times are recorded.

    Two weeks

  • 10-meter walk test

    The individual is on a 10-meter path. The assessment is performed in three repetitions and recorded in seconds.

    Two weeks

  • 30-second sit-to-stand test

    It is performed to evaluate lower extremity endurance by having the individual stand up from a chair with their arms crossed over their chest and then sit back down. The individual is instructed to repeat this as quickly as possible for 30 seconds. The score for this assessment is the number of times the person fully stands up from a sitting position with arms crossed within 30 seconds.

    Two weeks

  • Glittre Activities of Daily Living Test

    It consists of a cycle of standardized activities such as walking, carrying weights, climbing stairs, and moving objects on a shelf. The equipment required for the test includes a chair, steps, a shelf, a backpack, weights (0.5 kg-2.5 kg), and a stopwatch. The patient completes the 10-meter course created for the test for five laps, and the time is recorded.

    Two weeks

Secondary Outcomes (19)

  • Childhood Health Assessment Questionnaire (CHAQ)

    Two weeks

  • Juvenile Arthritis Quality of Life Questionnaire (JAQQ)

    Two weeks

  • Juvenile Arthritis Biopsychosocial Scale-JAB-Q-Patient

    Two weeks

  • Juvenile Arthritis Biopsychosocial Scale-JAB-Q-Family

    Two weeks

  • Pain Catastrophizing Scale-Parent (PCS-P)

    Two weeks

  • +14 more secondary outcomes

Study Arms (1)

Cases diagnosed with scleroderma

Child and adult scleroderma patients who visited the rheumatology outpatient clinic at a university hospital will complete a questionnaire.

Other: Questionnaire and functionality application for child and adult scleroderma patients

Interventions

Scales and functionality tests will be applied to cases diagnosed with scleroderma

Cases diagnosed with scleroderma

Eligibility Criteria

Age7 Years+
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

The study population will consist of individuals who come to the university hospital for routine controls.

You may qualify if:

  • Cases diagnosed with scleroderma,
  • Cases aged 7-18 years will be included.

You may not qualify if:

  • Advanced heart/lung/liver/kidney disease, neurological disease, and malignancies
  • Cases that are not willing to participate in the study will be excluded.
  • Having participated in a regular exercise program for the past 3 months
  • Individuals who are not willing to participate in the study
  • \*For adults diagnosed with scleroderma\*
  • Individuals diagnosed with scleroderma,
  • Individuals over the age of 18 will be included.
  • Advanced heart/lung/liver/kidney disease, neurological disease, and malignancies
  • Individuals who are not willing to participate in the study will be excluded.
  • Having participated in a regular exercise program for the past 3 months
  • Individuals who are not willing to participate in the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Hacettepe University

Çankaya, Ankara, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Scleroderma, SystemicScleroderma, DiffuseScleroderma, LocalizedJuvenile-onset scleroderma

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Connective Tissue DiseasesSkin and Connective Tissue DiseasesSkin Diseases

Intervention Hierarchy (Ancestors)

Data CollectionEpidemiologic MethodsInvestigative TechniquesHealth Care Evaluation MechanismsQuality of Health CareHealth Care Quality, Access, and EvaluationPublic HealthEnvironment and Public Health

Central Study Contacts

Orkun Tüfekçi, PT, PhD(c)

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
2 Weeks
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator, PT, PhD(c)

Study Record Dates

First Submitted

September 13, 2025

First Posted

September 19, 2025

Study Start

August 4, 2025

Primary Completion (Estimated)

August 1, 2027

Study Completion (Estimated)

August 4, 2027

Last Updated

September 19, 2025

Record last verified: 2025-08

Data Sharing

IPD Sharing
Will not share

Locations