VAP Incidence and Adequation to SRLF 2017 Diagnostic Among an Intensive Care Medicine Service for the Period 2022 à 2024

NCT07181824 | Recruiting

• 1 other identifier: 2025/0025
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to to analyze respiratory samples performed in mechanically ventilated ICU patients and to assess whether the SRLF criteria for defining VAP were respected among patients admited to the Intensive care medicine at a regional hospital en France

Conditions

Pneumonia Ventilator Associated

Keywords

Ventilatory associated pneumonia; VAP; Intensive Care medicine; Mechanical ventilation; Pneumonia

Outcome Measures

Primary Outcomes (1)

• SRLF VAP criteria

  Describe whether the respiratory samples obtained from ICU patients after \>48 hours of mechanical ventilation for suspected VAP met, or did not meet, the 2017 SRLF diagnostic criteria

  at day 0

Secondary Outcomes (6)

• microbial ecology in the ICU of CHSF

  at day 0

• antibiotic consumption generated by VAP

  at day 0

• morbidity and mortality associated with VAP

  at day 0

• duration of antibiotic therapy for a VAP episode

  at day 0

• characteristics of the initial antibiotic therapy

  at day 0

Study Arms (1)

VAP suspicion

Adult patients (\>18 years) under mechanical ventilation for \>48 hours and with a positive respiratory sample

Other: Diagnostic tedst

Interventions

Diagnostic tedst OTHER

* Radiologic signs: 2 consecutive thorax x-ray with new onset pneumonia AND * One of the following criteria * Fever \>38,3°C without any other cause * Leucocytes \< 4000/mm3 or ≥ 12000 /mm3 * AND at least two of the following * Purulent secretions * Cough or dyspnoea * Desaturation or increase in FiO2 (+20%)

VAP suspicion

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Population includes all patients admitted to the intensive care unit for the selected period, under mechanical ventilation.

You may qualify if:

• Adults ≥ 18 years
• Hospitalization in Intensive care unit for the period between 01/01/2022 and 31/12/2024
• Intubation and mechanical ventilation for \> 48h
• Positive respiratory sample

You may not qualify if:

• Decision of therapeutic limitation
• Organ donors
• Patient refuse to participate

Sponsors & Collaborators

• Centre Hospitalier Sud Francilien: lead

Study Sites (1)

Centre Hospitalier Sud Francilien

Corbeil-Essonnes, France, 91100, France

RECRUITING

MeSH Terms

Conditions

Pneumonia, Ventilator-Associated; Pneumonia

Condition Hierarchy (Ancestors)

Healthcare-Associated Pneumonia; Cross Infection; Infections; Respiratory Tract Infections; Lung Diseases; Respiratory Tract Diseases; Iatrogenic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Luis ENSENYAT MARTIN, MD

  Centre Hospitalier Sud Francilien

  PRINCIPAL INVESTIGATOR

• Abdoul DINE

  Centre Hospitalier Sud Francilien

  STUDY DIRECTOR

Central Study Contacts

Luis ENSENYAT MARTIN, MD

CONTACT

33 1 61 69 31 57; luis.ensenyatmartin@chsf.fr

Caroline TOURTE

CONTACT

33 1 61 69 31 50; caroline.tourte@chsf.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 12, 2025
• First Posted: September 18, 2025
• Study Start: August 25, 2025
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): June 30, 2026
• Last Updated: December 9, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)