Evaluation of the Effect of Tea Tree and Chlorhexidine Mouthwashes on Healing After Third Molar Extraction

NCT07180498 | Recruiting

• 1 other identifier: HRU/25.07.49
• Study Type: interventional
• Target: 54
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this clinical study is to compare the effects of mouthwashes containing Chlorhexidine and tea tree oil on edema, pain, and trismus after the extraction of impacted third molars. Additionally, the effects on periodontal health will be examined by comparing the gum healing processes of patients using both mouthwashes.The main questions it aims to answer are:

1. 1.Tea tree oil, said to have anti-inflammatory and antibacterial effects, could be an alternative to chlorhexidine in reducing postoperative complications after impacted tooth extraction.
2. 2.Does tea tree oil, which has antimicrobial effects, have as positive an impact on periodontal health as chlorhexidine?Researchers will compare tea tree oil to chlorhexidine (routinely prescribed after the extraction of an impacted wisdom tooth) to see if tea tree oil works to decrease postoperative complications.

Conditions

Postoperative Pain; Postoperative Complications; Trismus; Periodontal Health

Keywords

tea tree oil; third molar surgery; postoperative complications; chlorhexidine digluconate

Outcome Measures

Primary Outcomes (3)

• pain VAS measurement

  The patient will be given a chart with a 7-day VAS scale for pain control after tooth extraction. They will be asked to record their pain daily on a scale of 0 (no pain) to 10 (the worst imaginable pain) for 7 days, and to note how many painkillers they used.

  preoperative, postoperative day 2, post operative day 7

• amount of mouth opening

  Restriction in mouth opening for 7 days after impacted tooth extraction surgery

  preoperative, postoperative day 2, post operative day 7

• distance from the angulus to the labial commissure, external eye angle, tragus, pogonion, and nasal line

  The amount of facial swelling during the 7 days following impacted tooth extraction surgery

  preoperative, postoperative day 2, post operative day 7

Secondary Outcomes (1)

• Pocket depth measurement of the second molar tooth next to the extraction site and assessment of plaque presence

  preoperative, postoperative day 2, post operative day 7

Study Arms (2)

chlorhexidine group

ACTIVE COMPARATOR

They will be instructed to gargle with chlorhexidine after brushing their teeth three times daily for 7 days.

Drug: Chlorhexidine Gluconate 0.12% Mouthwash

tea tree oil group

EXPERIMENTAL

They will be instructed to gargle with 3 drops of tea tree oil added to 100 mL of water (approximately half a glass of water) after brushing their teeth three times daily for 7 days.

Drug: Tea Tree Oil mouthwash

Interventions

Chlorhexidine Gluconate 0.12% Mouthwash DRUG

Participants will be prescribed to gargle with chlorhexidine, which is the routine recommendation after brushing their teeth 3 times a day for 7 days after the impacted tooth extraction.

chlorhexidine group

Tea Tree Oil mouthwash DRUG

Participants will be prescribed to gargle with tea tree oil-containing water after brushing their teeth three times a day for 7 days following the extraction of an impacted tooth.

tea tree oil group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Individuals undergoing extraction of Class 2, Class B mandibular third molars impacted in the lower jaw (Pell \& Gregory).
• Individuals aged 18-65.
• Individuals must be in stable general health (e.g., free of serious cardiovascular or kidney disease).
• Individuals willing to use tea tree extract or other treatments.

You may not qualify if:

• Individuals with a known allergy or hypersensitivity to tea tree extract.
• Individuals with serious illnesses such as heart failure or kidney disease. Patients with bleeding disorders.
• Individuals during pregnancy and breastfeeding.
• Individuals taking medications that may interact with tea tree extract (e.g., blood thinners or antihypertensives)
• Individuals previously treated for edema.
• Individuals with chronic edema.

Sponsors & Collaborators

• Harran University: lead

Study Sites (1)

Harran University, Faculty of Dentistry

Sanliurfa, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Pain, Postoperative; Postoperative Complications; Trismus

Interventions

chlorhexidine gluconate; Mouthwashes

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms; Spasm; Neuromuscular Manifestations; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Biomedical and Dental Materials; Specialty Uses of Chemicals; Chemical Actions and Uses; Cosmetics; Manufactured Materials; Technology, Industry, and Agriculture

Study Officials

• Mine alkaya karagoz

  Harran University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Mine alkaya karagoz

CONTACT

905365417606; minekaragoz@harran.edu.tr

fatih yenigun

CONTACT

905369297833; ygnfth@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant professor

Study Record Dates

• First Submitted: September 1, 2025
• First Posted: September 18, 2025
• Study Start: April 15, 2025
• Primary Completion: October 30, 2025
• Study Completion: December 30, 2025
• Last Updated: September 18, 2025

Record last verified: 2025-09

Locations

TU (1)