Effectiveness of Whole Body Vibration on Health Outcomes in Older Adults With Dynapenic Abdominal Obesity

NCT07180485 | Not Yet Recruiting DMC

• 2 other identifiers: B11401015DTCRD113-E-14
• Study Type: interventional
• Target: 120
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study focuses on whole body vibration training (WBVT), a form of neuromuscular training that uses mechanical vibrations. WBVT has been shown to improve muscle function, bone mineral density, and quality of life. While some benefits have been observed in the elderly population, there remains a research gap concerning its effectiveness in older adults with dynapenic abdominal obesity. Therefore, the findings of this study will provide new evidence for health interventions targeting this specific group. This research targets outpatients aged 65 and above who meet the criteria for dynapenic abdominal obesity. It aims to evaluate the effects of WBVT on brain activity, osteoporosis, quality of life, and biological markers. The study period is from February 1, 2025, to January 31, 2027, with a planned sample size of 120 participants, equally divided into an experimental group and a control group (60 participants each).

Conditions

Dynapenia; Abdominal Obesity

Keywords

whole-body vibration training; brain activity; bone mineral density; quality of life; biomarkers

Outcome Measures

Primary Outcomes (3)

• blood tests

  Total Cholesterol (TC) Time Frame: Baseline, 3 months, 6 months；Description: Serum total cholesterol level measured in mg/dL. Reference value: \< 200 mg/dL. Triglycerides (TG) Time Frame: Baseline, 3 months, 6 months；Description: Serum triglyceride level measured in mg/dL. Reference value: \< 150 mg/dL. Low-Density Lipoprotein Cholesterol (LDL-C) Time Frame: Baseline, 3 months, 6 months；Description: Serum LDL cholesterol measured in mg/dL. Reference value: \< 130 mg/dL. High-Density Lipoprotein Cholesterol (HDL-C)Time Frame: Baseline, 3 months, 6 months；Description: Serum HDL cholesterol measured in mg/dL. Reference values: \> 40 mg/dL for men, \> 50 mg/dL for women. C-Reactive Protein (CRP)Time Frame: Baseline, 3months, 6 months；Description: Quantitative serum CRP level measured in mg/dL. Normal reference value: 0.3 mg/dL. Glycated Hemoglobin (HbA1c)Time Frame: Baseline, 3 months, 6 months；Description: HbA1c percentage measured in blood. Normal Brain-Derived Neurotroph in pg/mL using

  24 weeks

• dual-energy X-ray absorptiometry(DXA)

  This study employed dual-energy X-ray absorptiometry (DXA), a widely used and clinically safe method for assessing bone health. The DXA system (brand referenced in previous publications) operates by emitting a low-radiation dose (±10 μSv) X-ray beam to measure the extent of X-ray penetration through body tissues. Based on the absorption data, the device calculates bone mineral density (BMD). Since bones absorb more X-rays and have high penetrability, while fat absorbs less and has low penetrability, DXA effectively differentiates between tissue types. DXA results are typically interpreted using T-scores for BMD. A T-score ≥ -1.0 indicates normal bone density and good skeletal health. A T-score between -2.5 and -1.0 suggests low bone mass (osteopenia), indicating a decreased BMD but not yet at the threshold for osteoporosis. A T-score ≤ -2.5 defines osteoporosis, indicating significantly reduced BMD and a higher risk of fractures. Severe osteoporosis is diagnosed when a T-score ≤ -2.5.

  8 months

• quality of life questionnaire

  The Taiwan version of the World Health Organization Quality of Life questionnaire is a shortened version derived from the original 100-item WHOQOL-100 developed by the World Health Organization. Exploratory and confirmatory factor analyses of the questionnaire support a four-domain model consisting of physical health, psychological well-being, social relationships, and environment. The internal consistency (Cronbach's α) of these four domains ranges from 0.70 to 0.77. The questionnaire includes 28 items: one item for overall quality of life, one for general health, seven for physical health, six for psychological well-being, three for social relationships, and eight for environmental factors. The scale uses a 5-point Likert format based on frequency, intensity, capability, and evaluation. Higher scores indicate better quality of life.

  24 weeks

Study Arms (2)

whole body vibration training group

EXPERIMENTAL

Participants in the experimental group underwent whole-body vibration (WBV) training three times per week for a total duration of 24 weeks. During each session, participants stood barefoot on a vibration platform, maintaining a static squat position with knees bent at 30 degrees and feet shoulder-width apart. The training protocol gradually increased in duration, number of sets, and total exercise time from an initial 10 minutes to 30 minutes over the 24-week period. The vibration frequency was progressively raised from 20 Hz to 40 Hz, with a constant amplitude of 2 mm. Each 10-minute session included a 1-minute rest interval. Additionally, all participants were provided with the "Move for Health" handbook issued by the Health Promotion Administration, Ministry of Health and Welfare, Taiwan, as part of health education guidance. Post-intervention data collection was conducted at weeks 18 and 25 following the 24-week intervention program.

Behavioral: whole body vibration training

control group

PLACEBO COMPARATOR

The control group received the "Move for Health" handbook issued by the Health Promotion Administration, Ministry of Health and Welfare, Taiwan, and participated in 30-minute health education sessions over a 24-week period. The educational content included exercise-related information, an introduction to dynapenic abdominal obesity (DAO), associated risk factors, and potential health consequences. Post-intervention data collection was conducted at weeks 18 and 25 following the 24-week intervention program.

Behavioral: control group

Interventions

whole body vibration training BEHAVIORAL

whole body vibration training and health education booklet

whole body vibration training group

control group BEHAVIORAL

health education booklet

control group

Eligibility Criteria

• Age: 65 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• Outpatients aged 65 years or older
• Diagnosed with dynapenic abdominal obesity
• Able to understand and follow simple instructions
• Able to communicate clearly and express their own will
• Willing to sign the informed consent form

You may not qualify if:

• Inability to communicate in Mandarin or Taiwanese, resulting in inability to participate in research activities
• Severe visual or hearing impairment that hinders study participation
• Presence of cognitive impairment, musculoskeletal or severe osteoporosis-related conditions
• Refusal to sign the informed consent form

Sponsors & Collaborators

• Dalin Tzu Chi General Hospital: lead
• Buddhist Dalin Tzu Chi General Hospital: collaborator

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Related Links

• Related Info

MeSH Terms

Conditions

Obesity, Abdominal

Interventions

Control Groups

Condition Hierarchy (Ancestors)

Obesity; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Epidemiologic Research Design; Epidemiologic Methods; Investigative Techniques; Research Design; Methods

Study Officials

• Chang Shu Fang, professor

  National Taipei University of Nursing and Health Sciences

  STUDY CHAIR

Central Study Contacts

SHIH CHUN LIN

CONTACT

+88652648000; t780927t@yahoo.com.tw

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 21, 2025
• First Posted: September 18, 2025
• Study Start: October 1, 2025
• Primary Completion (Estimated): October 1, 2027
• Study Completion (Estimated): October 1, 2027
• Last Updated: September 18, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: approximate date since June 2025 to January 2027