Peripheral Artery Disease in Regular Hemodialysis Patients

NCT07179211 | Active Not Recruiting

• 1 other identifier: Soh-Med-25-7-19MS
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

Recent studies have reinforced the association between high NLR and PAD in hemodialysis patients. This highlights the need for further studies to confirm its predictive value and determine optimal cut-off thresholds tailored to local patient populations. Accordingly, the present study aims to investigate the relationship between NLR and the presence of PAD in patients undergoing regular hemodialysis. By establishing this association in a well-defined population, we hope to provide evidence that supports the use of NLR as a simple, cost-effective tool for PAD risk stratification and early intervention

Conditions

Chronic Kidney Disease

Outcome Measures

Primary Outcomes (2)

• The aim of this study is to evaluate the predictive value of the neutrophil-to- lymphocyte ratio (NLR) for the presence of peripheral artery disease (PAD) in patients undergoing regular hemodialysis.

  6months

• % of patients with affection in neutrophills to lymphocytes ratio in parient on regular hemodialysis.

  6 months

Eligibility Criteria

• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The present study aims to investigate the relationship between NLR and the presence of PAD in patients undergoing regular hemodialysis. By establishing this association in a well-defined population, we hope to provide evidence that supports the use of NLR as a simple, cost-effective tool for PAD risk stratification and early intervention

You may qualify if:

• Adult patients aged ≥18 years.
• Undergoing maintenance hemodialysis for at least 3 months (thrice weekly)
• Able to provide informed consent.
• Willing to undergo clinical and laboratory evaluations, including peripheral vascular assesment

You may not qualify if:

• Active infection or sepsis at the time of evaluation
• \* Patients who have a sedimentation rate of more than 60 mm/hour
• \*. Known autoimmune or hematologic disorders that may influence leukocyte count.
• Current use of immunosuppressive therapy, corticosteroids, or chemotherapy.5. History of malignancy.6. Patients with incomplete medical records or unable to undergo peripheral vascular assessment.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag faculty

Sohag, Egypt

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

CBC CRP Lipid profile

MeSH Terms

Conditions

Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 120 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident physician in the Department of General Internal Medicine

Study Record Dates

• First Submitted: September 2, 2025
• First Posted: September 17, 2025
• Study Start: July 13, 2025
• Primary Completion: January 13, 2026
• Study Completion (Estimated): July 13, 2026
• Last Updated: September 17, 2025

Record last verified: 2025-09

Locations

EG (1)