A Study of SCAD Using Stress Contrast Echocardiography

NCT07178509 | Recruiting

• 2 other identifiers: 24-0023181K23HL155506
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to fill knowledge gaps regarding microvascular perfusion and pressor response to stress among patients with history of spontaneous coronary artery dissection (SCAD) using stress contrast echocardiography.

Conditions

Spontaneous Coronary Artery Dissection

Outcome Measures

Primary Outcomes (3)

• Change in Microvascular Function

  Microvascular Function will be determined by Microvascular Blood Flow (Liters/Minute). Microvascular Blood Flow will be measured by a stress echocardiogram with contrast. A higher Microvascular Blood Flow indicated better blood flow circulation.

  Baseline, immediately after the Stress Echocardiography

• Change in Blood Pressure

  Change is blood pressure will be measured by a stress echocardiogram with contrast (mmHg).

  Baseline, immediately after the Stress Echocardiography

• Change in Heart Rate

  Change in heart rate will be measured by a stress echocardiogram with contrast (beats per minute).

  Baseline, immediately after the Stress Echocardiography

Study Arms (2)

Spontaneous coronary artery dissection (SCAD)

Subject has a history of spontaneous coronary artery dissection (SCAD)

Procedure: Stress Echocardiography with Contrast

Healthy Subjects

Subjects are healthy with no significant medical history

Procedure: Stress Echocardiography with Contrast

Interventions

Stress Echocardiography with Contrast PROCEDURE

Stress Echocardiography with Contrast will be used to assess heart function and blood flow response to stressors.

Healthy Subjects; Spontaneous coronary artery dissection (SCAD)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients will be recruited from the clinic and community.

You may qualify if:

• Adult \>18 years old
• Patient has a history of spontaneous coronary artery dissection (SCAD) OR patient is healthy with no significant medical history

You may not qualify if:

• Unable to give consent
• Allergic or have a history of adverse reaction to dobutamine, the Definity® ultrasound enhancing agent, or atropine.
• Has a known or suspected hypersensitivity to perflutren and therefore cannot be given Definity®.
• Pregnant.
• Unable to interrupt breastfeeding.
• Within 3 months of a heart attack.
• Severe aortic stenosis.
• Severe, uncontrolled hypertension (\>200/110 mmHg at baseline).

Sponsors & Collaborators

• Mayo Clinic: lead
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Study Sites (1)

Mayo Clinic

Rochester, Minnesota, 55905, United States

RECRUITING

MeSH Terms

Conditions

Coronary Artery Dissection, Spontaneous

Interventions

Contrast Media

Intervention Hierarchy (Ancestors)

Diagnostic Uses of Chemicals; Pharmacologic Actions; Chemical Actions and Uses; Specialty Uses of Chemicals

Study Officials

• Marysia Tweet, M.D., M.S.

  Mayo Clinic

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Pamela Engrav

CONTACT

507-255-6938; engrav.pamela@mayo.edu

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 2, 2025
• First Posted: September 17, 2025
• Study Start: November 25, 2025
• Primary Completion (Estimated): September 1, 2027
• Study Completion (Estimated): September 1, 2027
• Last Updated: January 7, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)