Canadian SCAD Study
Canadian Spontaneous Coronary Artery Dissection (SCAD) Cohort Study
1 other identifier
observational
750
2 countries
20
Brief Summary
SCAD (Spontaneous coronary artery dissection - tear in the arterial wall that is not related to trauma) is an under-diagnosed and poorly understood condition that mostly affects young women without common cardiovascular risk factors, and can result in heart attack and death. This observational study is designed to capture the disease's natural history and predisposing arteriopathies (medical conditions resulting in changes in the arteries), treatment strategies, long-term cardiovascular outcomes. It will also improve the diagnosis of SCAD on coronary angiography by participating clinicians, and provide guidance on investigating predisposing conditions.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2014
Longer than P75 for all trials
20 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2014
CompletedFirst Submitted
Initial submission to the registry
July 9, 2014
CompletedFirst Posted
Study publicly available on registry
July 11, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2020
CompletedAugust 10, 2018
August 1, 2018
6 years
July 9, 2014
August 8, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Composite in-hospital outcome
Composite of all-cause mortality, stroke, reinfarction (31), cardiogenic shock (requiring medical or mechanical hemodynamic support), congestive heart failure, severe ventricular arrhythmia (requiring defibrillation or antiarrhythmic agents), repeat revascularization (or unplanned revascularization), and cardiac transplantation, collectively termed in-hospital major adverse events (MAE)
During index admission
Composite follow-up outcome
Composite of all-cause mortality, stroke, recurrent MI (including recurrent dissection), congestive heart failure and repeat revascularization, collectively termed major adverse cardiac events (MACE).
3 years post index event
Eligibility Criteria
Prospective patients presenting with Spontaneous coronary artery dissection (SCAD)
You may qualify if:
- Patients admitted with troponin-positive ACS (NSTEMI or STEMI)
- Documented NA-SCAD on coronary angiogram (including diagnosis with OCT or IVUS)
You may not qualify if:
- Patients with troponin-negative ACS
- Patients with typical atherosclerotic coronary artery disease in other coronary arterial segments with diameter stenosis ≥50%
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (20)
Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
Royal Alexandra Hospital
Edmonton, Alberta, Canada
University of Alberta
Edmonton, Alberta, Canada
St. Paul's Hospital
Vancouver, British Columbia, Canada
Vancouver General Hospital
Vancouver, British Columbia, Canada
Saint Boniface General Hospital
Winnipeg, Manitoba, Canada
Queen Elizabeth Health Sciences Centre
Halifax, Nova Scotia, Canada
Hamilton Health Sciences General Site
Hamilton, Ontario, Canada
Saint Mary's
Kitchener, Ontario, Canada
London Health Sciences
London, Ontario, Canada
Southlake Regional Hospital
Newmarket, Ontario, Canada
Ottawa Heart Institute
Ottawa, Ontario, Canada
Rough Valley Health System
Scarborough Village, Ontario, Canada
Saint Michael's Hospital
Toronto, Ontario, Canada
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada
McGill University Health Centre (CUSM)
Montreal, Quebec, Canada
Montreal Heart Institute
Montreal, Quebec, Canada
University of Montreal (CHUM)
Montreal, Quebec, Canada
Regina General Hospital
Regina, Saskatchewan, Canada
Royal University Hospital
Saskatoon, Saskatchewan, Canada
Related Publications (4)
Saw J. Coronary angiogram classification of spontaneous coronary artery dissection. Catheter Cardiovasc Interv. 2014 Dec 1;84(7):1115-22. doi: 10.1002/ccd.25293. Epub 2013 Dec 4.
PMID: 24227590BACKGROUNDSaw J, Poulter R, Fung A, Wood D, Hamburger J, Buller CE. Spontaneous coronary artery dissection in patients with fibromuscular dysplasia: a case series. Circ Cardiovasc Interv. 2012 Feb 1;5(1):134-7. doi: 10.1161/CIRCINTERVENTIONS.111.966630. No abstract available.
PMID: 22338003BACKGROUNDSaw J, Ricci D, Starovoytov A, Fox R, Buller CE. Spontaneous coronary artery dissection: prevalence of predisposing conditions including fibromuscular dysplasia in a tertiary center cohort. JACC Cardiovasc Interv. 2013 Jan;6(1):44-52. doi: 10.1016/j.jcin.2012.08.017. Epub 2012 Dec 19.
PMID: 23266235BACKGROUNDSaw J, Aymong E, Mancini GB, Sedlak T, Starovoytov A, Ricci D. Nonatherosclerotic coronary artery disease in young women. Can J Cardiol. 2014 Jul;30(7):814-9. doi: 10.1016/j.cjca.2014.01.011. Epub 2014 Jan 23.
PMID: 24726091BACKGROUND
MeSH Terms
Conditions
Study Officials
- PRINCIPAL INVESTIGATOR
Jacqueline Saw, MD
Vancouver General Hospital, University of British Columbia
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 3 Years
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Director of Research
Study Record Dates
First Submitted
July 9, 2014
First Posted
July 11, 2014
Study Start
June 1, 2014
Primary Completion
June 1, 2020
Study Completion
December 1, 2020
Last Updated
August 10, 2018
Record last verified: 2018-08