Intraoperative Perfusion Index and Mortality

NCT07164339 | Active Not Recruiting

• 1 other identifier: F-24084045
• Study Type: observational
• Target: 425,000
• Locations: 1 country
• Sites: 1

Brief Summary

This study will use routinely collected perioperative data to examine the relationship between intraoperative perfusion index and postoperative outcomes, including mortality.

Conditions

Hemodynamic; Perfusion Index; Intraoperative Hemodyamic Monitoring

Outcome Measures

Primary Outcomes (1)

• All-cause mortality

  30 days from time of surgery

Secondary Outcomes (5)

• Composite Adverse Outcome

  30 days from time of surgery

• Postoperative ICU Admission

  30 days from date of surgery

• Reoperation

  30 days from date of surgery

• Prolonged Length of Stay (LOS)

  Through hospital discharge (max. 6 months from surgery date)

• Acute Kidney Injury

  30 days from date of surgery

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

We include every adult patient who underwent general anesthesia for non-cardiac surgery of any type in Danish hospitals in The Capital and Zealand Regions from January 2017 - December 2024.

You may qualify if:

• Patients above 18 years of age who underwent general anesthesia for non-cardiac surgery of any type

You may not qualify if:

• No registration of intraoperative perfusion index or no information on vital status 30 days after surgery

Sponsors & Collaborators

• Copenhagen University Hospital, Hvidovre: lead

Study Sites (1)

Copenhagen University Hospital - Hvidovre

Hvidovre, 2650, Denmark

Location

Related Publications (2)

• Krone S, Bokoch MP, Kothari R, Fong N, Tallarico RT, Sturgess-DaPrato J, Pirracchio R, Zarbock A, Legrand M. Association between peripheral perfusion index and postoperative acute kidney injury in major noncardiac surgery patients receiving continuous vasopressors: a post hoc exploratory analysis of the VEGA-1 trial. Br J Anaesth. 2024 Apr;132(4):685-694. doi: 10.1016/j.bja.2023.11.054. Epub 2024 Jan 19.

  PMID: 38242802 BACKGROUND

• Agerskov M, Thusholdt ANW, Holm-Sorensen H, Wiberg S, Meyhoff CS, Hojlund J, Secher NH, Foss NB. Association of the intraoperative peripheral perfusion index with postoperative morbidity and mortality in acute surgical patients: a retrospective observational multicentre cohort study. Br J Anaesth. 2021 Sep;127(3):396-404. doi: 10.1016/j.bja.2021.06.004. Epub 2021 Jul 3.

  PMID: 34226038 BACKGROUND

Study Officials

• Nicolai B Foss, Prof

  Copenhagen University Hospital, Hvidovre

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: August 25, 2025
• First Posted: September 10, 2025
• Study Start: December 18, 2024
• Primary Completion: October 1, 2025
• Study Completion: October 1, 2025
• Last Updated: September 10, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

DK (1)