NCT07164196|Completed
Endometriosis-Angiopoietin-like Protein-4
Evaluation of Angiopoietin-like Protein 4 Levels in Patients With Endometriosis
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Evaluation of Angiopoietin-like Protein 4 Levels in Patients With Endometriosis
Sponsor study identifier
observational
80
1 country
1
Study Start
June 5, 2025
Actual (reported)Primary Completion
August 21, 2025
Actual (reported)Study Completion
September 2, 2025
Actual (reported)Endometriosis is a chronic inflammatory disease associated with pelvic pain, dyspareunia, and impaired ovarian reserve. Cancer antigen-125 (CA-125) is widely studied but limited by low specificity, while angiopoietin-like protein-4 (ANGPTL4) has emerged as a potential biomarker due to its role in angiogenesis and inflammation. In the current study it was aimed to investigate serum and peritoneal fluid ANGPTL4 levels in women with endometriosis compared to healthy controls, and to evaluate their associations with clinical symptoms, serum CA-125, and anti-Müllerian hormone levels.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
September 2, 2025
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 5, 2025
Actual (reported)August 21, 2025
Actual (reported)September 2, 2025
Actual (reported)September 2, 2025
Actual (reported)September 10, 2025
Actual (reported)Serum and peritoneal fluid Angiopoietin-like protein-4 level
Nanogram/milliliter
day 1
Serum cancer antigen 125 level
day 1
The study group included women with endometriosis. The study group consisted of women diagnosed with endometriosis who consecutively underwent laparoscopic endometriosis surgery.
Control group consisted of healthy women. The control group consisted of women who consecutively visited the outpatient clinic for routine gynecologic examinations and had no known diseases.
Measurement of peritoneal fluid levels of Angiopoietin-like protein-4 (ANGPTL4) level by ELISA method.
Measurement of venous blood serum level of CA-125 level by ELISA method.
Study population includes a total of 80 participants. The study group consists of 40 women with the diagnosis of endometriosis, and the control group consists of 40 healthy women.
Ankara Bilkent City Hospital
Ankara, Not Valid, 06100, Turkey (Türkiye)
Campara K, Rodrigues P, Viero FT, da Silva B, Trevisan G. A systematic review and meta-analysis of advanced oxidative protein products levels (AOPP) levels in endometriosis: Association with disease stage and clinical implications. Eur J Pharmacol. 2025 Jun 5;996:177434. doi: 10.1016/j.ejphar.2025.177434. Epub 2025 Feb 28.
Makoui MH, Fekri S, Makoui RH, Ansari N, Esmaeilzadeh A. The Role of Mast Cells in the Development and Advancement of Endometriosis. Am J Reprod Immunol. 2025 Mar;93(3):e70019. doi: 10.1111/aji.70019.
Serum samples were collected through antecubital venous blood sampling. In the study group, serum samples were obtained just before laparoscopy, while peritoneal fluid (PF) samples were collected from the Douglas pouch during trocar insertion into the abdominal cavity. Serum and PF levels of Angiopoietin-like protein-4 were analyzed.
Merve Didem Eşkin Tanrıverdi, MD
Ankara City Hospital Bilkent
80 participants (actual enrollment reported by the registry).
First Submitted
September 2, 2025
First Posted
September 10, 2025
Study Start
June 5, 2025
Actual (reported)Pelvic Pain Electro-Acupuncture
Measurement of venous blood serum level of Angiopoietin-like protein-4 (ANGPTL4) Level level by ELISA method.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
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Falcone T, Flyckt R. Clinical Management of Endometriosis. Obstet Gynecol. 2018 Mar;131(3):557-571. doi: 10.1097/AOG.0000000000002469.
Brown R, Imran SA, Wilkinson M. Lipopolysaccharide (LPS) stimulates adipokine and socs3 gene expression in mouse brain and pituitary gland in vivo, and in N-1 hypothalamic neurons in vitro. J Neuroimmunol. 2009 Apr 30;209(1-2):96-103. doi: 10.1016/j.jneuroim.2009.02.001. Epub 2009 Mar 3.
Primary Completion
August 21, 2025
Actual (reported)Study Completion
September 2, 2025
Actual (reported)Last Updated
September 10, 2025
Record last verified: 2025-09
IPD are available which may be shared in necessary conditions.
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Source: ClinicalTrials.gov.
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