The Effect of Dual Task Training on Cognitive in Alzheimer's Disease

NCT07163039 | Not Yet Recruiting

• 1 other identifier: 63.2025fbu
• Study Type: interventional
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

This randomized controlled clinical trial aims to evaluate the effectiveness of dual-task training on cognitive functions in patients with Alzheimer's disease. Participants will be randomly assigned to either a dual-task training group or a conventional exercise group. The intervention will last 8 weeks, with three supervised sessions per week. Cognitive performance, mobility, balance, and quality of life will be assessed before and after the intervention.

Conditions

Alzheimer Disease

Keywords

Alzheimer; Dual-Task Training

Outcome Measures

Primary Outcomes (5)

• d2 Test of Attention

  A widely used neuropsychological test evaluating visual attention and processing speed. Participants are asked to quickly and accurately mark target symbols (e.g., the letter "d" with two dashes) among distractors on a sheet consisting of similar letters and symbols.

  From enrollment to the end of treatment at 8 weeks

• Trail Making Test Part A (TMT-A)

  Assesses visual attention, processing speed, and psychological flexibility. The participant is required to connect numbered circles from 1 to 25 in order as quickly as possible.

  From enrollment to the end of treatment at 8 weeks

• Stroop Test

  Stroop Test: Evaluates executive functions and attentional control. The participant must state the ink color of a word rather than reading the written word itself (e.g., the word "Blue" written in red ink should be answered as "red")

  From enrollment to the end of treatment at 8 weeks

• Trail Making Test Part B (TMT-B):

  Trail Making Test Part B (TMT-B): Used to assess executive functions, cognitive flexibility, and attention. The participant alternates between numbers and letters in sequence (1-A-2-B-3-C…)

  From enrollment to the end of treatment at 8 weeks

• Montreal Cognitive Assessment (MoCA)

  Montreal Cognitive Assessment (MoCA): Evaluates memory, attention, executive functions, and visuospatial skills. It is a standard and validated tool for monitoring cognitive status and comparing pre- and post-intervention performance in Alzheimer's patients

  From enrollment to the end of treatment at 8 weeks

Secondary Outcomes (13)

• Symbol Digit Modalities Test (SDMT)

  From enrollment to the end of treatment at 8 weeks

• Functional Near-Infrared Spectroscopy (fNIRS)

  From enrollment to the end of treatment at 8 weeks

• Disability Assessment for Dementia (DAD)

  From enrollment to the end of treatment at 8 weeks

• Dual Task Protocol

  From enrollment to the end of treatment at 8 weeks

• Performance Measures: Walking speed

  From enrollment to the end of treatment at 8 weeks

Study Arms (2)

Dual-task motor-cognitive training

EXPERIMENTAL

Participants assigned to this group will undergo dual-task motor-cognitive training, which combines physical exercises with simultaneous cognitive tasks. Sessions will last 45-60 minutes, three times per week, for 8 weeks. Exercises will include gait and balance activities performed while engaging in cognitive tasks such as arithmetic, memory recall, or word association.

Other: Dual-Task Motor-Cognitive Training

Conventional Exercise Training

ACTIVE COMPARATOR

Participants in this group will receive a conventional exercise program focusing on strength, flexibility, and balance without a cognitive component. Sessions will last 45-60 minutes, three times per week, for 8 weeks, and will be supervised by a physiotherapist.

Other: Conventional Exercise Training

Interventions

Dual-Task Motor-Cognitive Training OTHER

Participants assigned to this group will undergo dual-task motor-cognitive training, which combines physical exercises with simultaneous cognitive tasks. Sessions will last 45-60 minutes, three times per week, for 8 weeks. Exercises will include gait and balance activities performed while engaging in cognitive tasks such as arithmetic, memory recall, or word association.

Dual-task motor-cognitive training

Conventional Exercise Training OTHER

Participants in this group will receive a conventional exercise program focusing on strength, flexibility, and balance without a cognitive component. Sessions will last 45-60 minutes, three times per week, for 8 weeks, and will be supervised by a physiotherapist.

Conventional Exercise Training

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥ 60 years
• Diagnosed with mild-stage Alzheimer's disease (According to DSM-5 or NINCDS-ADRDA criteria)
• MoCA score between 10-25 (Indicating sufficient cognitive capacity for dual-task training)
• Ability to walk independently or with minimal assistance
• Adequate hearing and vision to enable communication
• Physical and mental capacity to participate in the dual-task training protocol
• Provision of written informed consent (signed informed consent form)

You may not qualify if:

• Diagnosis of advanced-stage Alzheimer's disease (MoCA \< 10)
• Presence of additional neurological disorders affecting the motor system (e.g. Parkinson's disease, stroke, multiple sclerosis)
• Severe hearing or vision impairment (inability to respond to visual or auditory stimuli)
• History of psychiatric disorders (e.g., major depression, schizophrenia)
• Orthopedic or cardiopulmonary conditions that would prevent participation in dual-task training
• Participation in another cognitive or physical rehabilitation program within the last 3 months
• Individuals with unstable cognitive status due to recent medication changes

Sponsors & Collaborators

• Fenerbahce University: lead

MeSH Terms

Conditions

Alzheimer Disease

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Study Officials

• Sümeyye AKÇAY, PhD

  Fenerbahçe University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Sümeyye AKÇAY, PhD

CONTACT

+90 542 400 25 53; sumeyye.akcay@fbu.edu.tr

Burcu AKKURT, PhD

CONTACT

05536046713; burcu.akkurt@fbu.edu.tr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: August 21, 2025
• First Posted: September 9, 2025
• Study Start: September 1, 2025
• Primary Completion: October 1, 2025
• Study Completion: May 1, 2026
• Last Updated: September 9, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share