Perioperative Outcomes for Children With Preoperative URTI Symptoms After COVID-19 Pandemic

NCT07157111 | Completed DMC

• 1 other identifier: PPOC
• Study Type: observational
• Target: 2,392
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to investigate the impact of the COVID-19 pandemic on perioperative outcomes in children with preoperative URTI symptoms and to explore whether the COVID-19 pandemic affected the additional surgical risk associated with preoperative URTI symptoms. The main question it aims to answer is the appropriate timing of elective non-cardiac surgery in the post-COVID-19 era.

Conditions

URTI; Postoperative Complications; COVID - 19; Elective Non-cardiac Surgery; Perioperative Respiratory Adverse Events

Outcome Measures

Primary Outcomes (1)

• postoperative complications

  The postoperative complications including hemorrhage, infection, gastrointestinal complications, respiratory adverse events (RAE), and recurrence of the primary disease.

  7days

Secondary Outcomes (5)

• Intraoperative RAE

  1day

• Emergence RAE

  1day

• PACU stay

  1hour

• Total hospital length of stay

  10days

• Postoperative length of stay

  7days

Study Arms (4)

S1 group

children with preoperative upper respiratory tract infections symptoms undergoing elective non-cardiac surgery from January 1, 2015, to December 31, 2019

C1 group

children without preoperative upper respiratory tract infections undergoing elective non-cardiac surgery from January 1, 2015, to December 31, 2019

S2 group

children with preoperative upper respiratory tract infections symptoms undergoing elective non-cardiac surgery from January 1, 2020, to December 31, 2024

C2 group

children without preoperative upper respiratory tract infections symptoms undergoing elective non-cardiac surgery from January 1, 2020, to December 31, 2024

Eligibility Criteria

• Age: 1 Year - 12 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Pediatric patients aged 0-12 years who underwent elective non-cardiac surgery at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology between January 2015 and December 2024.

You may qualify if:

• Aged 0-12 years
• ASA physical status classification I-III
• Undergoing non-cardiac surgery
• Children presenting with mild URTI symptoms within 2 weeks before surgery

You may not qualify if:

• Presenting with severe underlying diseases (e.g., congenital heart disease, immunodeficiency)
• Presenting with a single symptom of fever that can be explained by other diseases
• Day surgery
• Children with abnormal preoperative chest X-rays

Sponsors & Collaborators

• aijun xu: lead

Study Sites (1)

Tongji Hospital

Wuhan, Hubei, 430030, China

Location

MeSH Terms

Conditions

Postoperative Complications; COVID-19

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• aihua Du, Dr.

  Tongji Hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: August 28, 2025
• First Posted: September 5, 2025
• Study Start: September 1, 2025
• Primary Completion: October 10, 2025
• Study Completion: October 10, 2025
• Last Updated: November 21, 2025

Record last verified: 2025-11

Locations

CN (1)