Impact of Plant Proteins and Exercise on Protein Metabolism in Older Adults

NCT07155824 | Recruiting

• 2 other identifiers: RBHP 2023 RICHARD 2ANSM
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

To gain mechanistic insights by examining the impact of innovative plant-protein fibre products, physical activity interventions on digestibility, amino acid bioavailability and whole-body protein metabolism in older persons

Conditions

Eldery People; Sedentarity

Outcome Measures

Primary Outcomes (1)

• Splanchnic extraction of amino acids

  Change in splanchnic extraction of amino acids in response to standardized test meals (vegetal \& animal proteins), assessed before and after a 12-week physical activity program.

  At baseline (Week 0) and at follow-up (Weeks 12-13).

Secondary Outcomes (2)

• Whole body protein metabolism

  At baseline (Week 0) and at follow-up (Weeks 12-13).

• Skeletal muscle signaling markers

  At baseline (Week 0) and at follow-up (Weeks 12-13) following only the plant protein standardized meal

Study Arms (1)

Dietary proteins and physical activity

EXPERIMENTAL

Effect of physical activity program on protein metabolism following ingestion of whey or plant protein blend

Dietary Supplement: Whey and plant protein blend

Interventions

Whey and plant protein blend DIETARY_SUPPLEMENT

The 12 week intervention will involve 2 weekly group exercise sessions incorporating strength and balance exercises, along with home-based exercise focused on increasing time spent walking.

Also known as: Physical activity

Dietary proteins and physical activity

Eligibility Criteria

• Age: 65 Years+
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• BMI 22-30 kg/m²
• Inactive (\<150 minutes of moderate to vigorous physical activity per week and no regular resistance training),
• Covered by a social security system
• Agrees to undergo the study interventions (undirect calorimetry, functional tests, physical activity program)

You may not qualify if:

• Hamilton HAD scale with a score \> 9
• Subject with a pathology or treatment (diabetic on insulin, corticosteroids \> 8 days, neuroleptics, anticoagulant, antiplatelet) judged by the investigator as incompatible with the study
• Subject with unstabilized thyroid dysfunction for at least 3 months
• Subject with unstabilized hypertension for at least 3 months
• Subject with a medical and/or surgical history judged by the investigator as incompatible with the trial
• More than 21 alcoholic drinks per week
• Heavy smoker (\>10 cigarettes/day)
• Currently participating in another intervention study
• Absence of informed consent
• Inability to participate in physical activity
• Allergy(ies) or refusal to consume one of the foods tested as part of the the study
• Allergy to local anesthetics
• Declared glaucoma
• Prostate hypertrophy
• Refusal to register in the national file of volunteers who participate in research involving human beings

Sponsors & Collaborators

• University Hospital, Clermont-Ferrand: lead
• Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement: collaborator
• Université d'Auvergne: collaborator
• Friedrich-Alexander-Universität Erlangen-Nürnberg: collaborator
• University College Dublin: collaborator
• University of Padova: collaborator

Study Sites (1)

CHU de Clermont-Ferrand

Clermont-Ferrand, 63000, France

RECRUITING

MeSH Terms

Interventions

Whey; Exercise

Intervention Hierarchy (Ancestors)

Milk; Beverages; Diet, Food, and Nutrition; Physiological Phenomena; Dairy Products; Food; Food and Beverages; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Yves Boirie

  CHU de Clermont-Ferrand

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Lise Laclautre

CONTACT

+33473754963; promo_interne_drci@chu-clermontferrand.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Controled, monocentric, open label study

Study Record Dates

• First Submitted: July 22, 2024
• First Posted: September 4, 2025
• Study Start: August 26, 2025
• Primary Completion (Estimated): February 1, 2027
• Study Completion (Estimated): February 1, 2027
• Last Updated: September 4, 2025

Record last verified: 2025-08

Locations

FR (1)