Effects of Early Cardiopulmonary Rehabilitation in Patients With Acute Decompensated Heart Failure

NCT07155421 | Recruiting

• 1 other identifier: bakircaymzeren09
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Acute decompensated heart failure (ADHF) is a severe condition characterized by rapid deterioration of cardiac function, leading to impaired oxygen delivery and multi-organ dysfunction. ADHF often results in reduced physical and respiratory capacity, greater dependence on oxygen support, difficulty performing daily activities, and prolonged hospital stays. In recent years, early exercise-based cardiopulmonary rehabilitation (CPR) has been introduced as part of heart failure management. Evidence suggests that early CPR improves overall health and cardiac function in heart failure patients. However, data regarding its effects in ADHF remain limited. While some studies indicate that early CPR enhances physical function, its impact on respiratory parameters and clinical outcomes is less well established. Cardiopulmonary rehabilitation is a multidisciplinary program designed to promote physical, psychological, and social recovery in patients with cardiovascular and pulmonary diseases. It includes exercise training, education, psychosocial support, and behavioral strategies. Early CPR specifically aims to improve cardiovascular and respiratory functions in heart failure patients. Initiating CPR in the early phase of ADHF may accelerate recovery, strengthen cardiopulmonary function, shorten hospitalization, and improve quality of life. This study aims to evaluate the effects of early CPR on functional capacity, hemodynamic parameters, and respiratory parameters in patients with ADHF.

Conditions

Heart Failure

Outcome Measures

Primary Outcomes (2)

• Functional capacity

  It will be evaluated using 6-min walk test according to the guideline of American Thoracic Society

  At baseline and at hospital discharge, up to 14 days after admission

• Physical performance

  It will evaluated using Short Physical Performance Battery.

  At baseline and at hospital discharge, up to 14 days after admission

Secondary Outcomes (5)

• Maximum inspiratory and expiratory capacity

  At baseline and at hospital discharge, up to 14 days after admission

• Hemodynamic responses to exercise

  At baseline and at hospital discharge, up to 14 days after admission

• Hemodynamic responses to exercise

  At baseline and at hospital discharge, up to 14 days after admission

• Hemodynamic responses to exercise

  At baseline and at hospital discharge, up to 14 days after admission

• Subjective symptom responses to exercise

  At baseline and at hospital discharge, up to 14 days after admission

Study Arms (2)

Early cardiopulmonary rehabilitation group

EXPERIMENTAL

Exercise-based cardiopulmonary rehabilitation will be applied to this group during the hospital stay every day for 3 times a day.

Other: Early Cardiopulmonary Rehabilitation; Other: Routine in-hospital care

Control Group

OTHER

Routine in-hospital care will be applied to this group.

Other: Routine in-hospital care

Interventions

Early Cardiopulmonary Rehabilitation OTHER

An individualized CPR program including positioning, deep breathing exercises (diaphragmatic and segmental breathing exercises), pursed-lip breathing exercises, breathing exercises using incentive spirometry, and progressive mobilization exercises (in-bed range of motion exercises, sitting, standing, and walking exercises)

Early cardiopulmonary rehabilitation group

Routine in-hospital care OTHER

Routine in-hospital care for acute decompansated heart failure

Control Group; Early cardiopulmonary rehabilitation group

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients hospitalized with a diagnosis of acute decompensated heart failure
• Being clinically stable

You may not qualify if:

• Having diagnosed pulmonary, neurological, renal, liver, gastrointestinal, orthopedic or oncological pathologies
• Having cardiomyopathy or congestive pericarditis
• Recent heart surgery in the past 6 months
• New or suspected thromboembolic event
• Presence of open wounds, ulcerations or major dermatological diseases in the lower extremities

Sponsors & Collaborators

• Izmir Bakircay University: lead
• Istanbul University - Cerrahpasa: collaborator
• Saglik Bilimleri Universitesi: collaborator
• Yeditepe University: collaborator

Study Sites (1)

Istanbul University- Cerrahpasa, Cardiology Institute

Istanbul, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Heart Failure

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Central Study Contacts

Kiymet Muammer, PT, PhD

CONTACT

+90 552 2058527; kiymet.muammer@iuc.edu.tr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: August 25, 2025
• First Posted: September 4, 2025
• Study Start: November 10, 2025
• Primary Completion: December 1, 2025
• Study Completion: December 1, 2025
• Last Updated: December 4, 2025

Record last verified: 2025-08

Locations

TU (1)