NCT07150923

Brief Summary

This is a hybrid type 3 effectiveness-implementation parallel cluster randomized superiority trial designed to compare two strategies to promote early supraglottic airway (SA) rescue during neonatal resuscitation, with a focus on implementation outcomes.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
36,503

participants targeted

Target at P75+ for not_applicable

Timeline
41mo left

Started Jan 2026

Longer than P75 for not_applicable

Geographic Reach
1 country

30 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress9%
Jan 2026Sep 2029

First Submitted

Initial submission to the registry

August 27, 2025

Completed
6 days until next milestone

First Posted

Study publicly available on registry

September 2, 2025

Completed
4 months until next milestone

Study Start

First participant enrolled

January 1, 2026

Completed
2.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2028

Expected
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2029

Last Updated

February 27, 2026

Status Verified

February 1, 2026

Enrollment Period

2.7 years

First QC Date

August 27, 2025

Last Update Submit

February 26, 2026

Conditions

Keywords

Neonatal ResuscitationDelivery Room ResuscitationPositive pressure ventilationSupraglottic AirwayLaryngeal Mask AirwaysImplementation ResearchInfant, Newborn

Outcome Measures

Primary Outcomes (1)

  • Penetration of early SA rescue

    Proportion of eligible patients treated with SA as an early rescue device. Excludes SA after intubation attempt.

    Up to 2 years

Secondary Outcomes (2)

  • Initial adoption of early SA rescue

    Up to 2 years

  • Sustainment of early SA rescue

    Up to 1 year

Other Outcomes (5)

  • Neonatal Intensive Care Unit (NICU) Admission

    Up to 30 days of life

  • Hypoxic Ischemic Encephalopathy (HIE)

    Up to 30 days of life

  • Any exposure to Endotracheal Tube

    Up to 30 days of life

  • +2 more other outcomes

Study Arms (2)

Enhanced Standard of Care ("Enhanced")

ACTIVE COMPARATOR
Other: Enhanced Standard of Care ("Enhanced")

Enhanced Standard of Care Plus Facilitation ("Enhanced-Plus")

ACTIVE COMPARATOR
Other: Enhanced Standard of Care ("Enhanced-Plus")

Interventions

Enhanced Standard of Care ("Enhanced") will include: Educational Materials and Outreach, Local Champions, Train the Trainer, Local Simulation Training, and SA Starter Packs.

Enhanced Standard of Care ("Enhanced")

Enhanced Standard of Care ("Enhanced-Plus") will include: Educational Materials and Outreach, Local Champions, Train the Trainer, Local Simulation Training, SA Starter Packs, and three additional intensive external facilitation components.

Enhanced Standard of Care Plus Facilitation ("Enhanced-Plus")

Eligibility Criteria

Age0 Days+
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Employed full-time by the hospital, affiliated practice, or affiliated university in a role that involves newborn resuscitation
  • Fluent in English
  • Oversee the care of newborns on a local level (e.g. nurse manager) or a hospital level (e.g. Chief Quality and Safety Officer)
  • Fluent in English

You may not qualify if:

  • Population 1b: Clinical providers who participate in qualitative interviews
  • Employed full-time by the hospital, affiliated practice, or affiliated university in a role that involves newborn resuscitation
  • Fluent in English
  • Population 2: Patients who receive neonatal resuscitation at birth
  • Inborn (not transferred to the hospital after birth)
  • ≥34 weeks' gestation at birth, based on best obstetrical estimate
  • Received PPV during neonatal resuscitation (as per provider's clinical assessment)
  • Congenital diaphragmatic hernia
  • Airway anomalies

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (30)

University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States

RECRUITING

University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States

RECRUITING

Sharp Chula Vista Medical Center

Chula Vista, California, 91911, United States

NOT YET RECRUITING

Sharp Grossmont Hospital

La Mesa, California, 91942, United States

NOT YET RECRUITING

Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States

NOT YET RECRUITING

Rady Children's NICU at Rancho Springs Medical Center

Murrieta, California, 92562, United States

NOT YET RECRUITING

Lucile Packard Children's Hospital

Palo Alto, California, 94304, United States

RECRUITING

Jacobs Medical Center at University of California San Diego Health

San Diego, California, 92037, United States

NOT YET RECRUITING

Sharp Mary Birch Hospital for Women & Newborns

San Diego, California, 92123, United States

NOT YET RECRUITING

ChristianaCare

Newark, Delaware, 19718, United States

RECRUITING

St. John's Children's Hospital

Springfield, Illinois, 62701, United States

NOT YET RECRUITING

Riley Hospital for Children

Indianapolis, Indiana, 46202, United States

NOT YET RECRUITING

MaineHealth Mid Coast Hospital

Brunswick, Maine, 04011, United States

RECRUITING

MaineHealth Maine Medical Center

Portland, Maine, 04102, United States

RECRUITING

Tufts Medical Center

Boston, Massachusetts, 02111, United States

RECRUITING

Mayo Clinic

Rochester, Minnesota, 55905, United States

RECRUITING

Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States

NOT YET RECRUITING

South Shore University Hospital

Bay Shore, New York, 11706, United States

NOT YET RECRUITING

Lenox Hill Hospital

New York, New York, 10075, United States

NOT YET RECRUITING

Cohen Children's Medical Center

Queens, New York, 11040, United States

NOT YET RECRUITING

University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27599, United States

NOT YET RECRUITING

Atrium Health Levine Children's Hospital

Charlotte, North Carolina, 28203, United States

RECRUITING

Good Samaritan Hospital

Cincinnati, Ohio, 45220, United States

NOT YET RECRUITING

Nationwide Children's Hospital

Columbus, Ohio, 43205, United States

NOT YET RECRUITING

Oklahoma Children's Hospital

Oklahoma City, Oklahoma, 73104, United States

NOT YET RECRUITING

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

RECRUITING

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19146, United States

RECRUITING

Parkland Health

Dallas, Texas, 75235, United States

RECRUITING

Texas Children's Hospital

Houston, Texas, 77030, United States

NOT YET RECRUITING

Children's Wisconsin

Milwaukee, Wisconsin, 53226, United States

RECRUITING

Study Officials

  • Elizabeth E Foglia, MD, MSCE

    Children's Hospital of Philadelphia

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Elizabeth E Foglia, MD, MSCE

CONTACT

Christopher P Bonafide, MD, MSCE

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Model Details: Hybrid type 3 effectiveness-implementation parallel cluster randomized superiority trial
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 27, 2025

First Posted

September 2, 2025

Study Start

January 1, 2026

Primary Completion (Estimated)

September 1, 2028

Study Completion (Estimated)

September 1, 2029

Last Updated

February 27, 2026

Record last verified: 2026-02

Data Sharing

IPD Sharing
Will not share

Locations