Cardiological Drug Classes And Falls in Older Adults

NCT07150754 | Completed

• 1 other identifier: PHARMACOGERIA092025
• Study Type: observational
• Target: 100,000
• Locations: 1 country
• Sites: 1

Brief Summary

Heat failure is a fast gowing health issue with a rising incidence in older adults. Recommendations have recently been published to treat heart failure, but most clinical trials leading to these recommendations tended to exclude older adults. Older adults are at higher risk of falls and severe consequences of falls. All heart failure treatments are at risk of causing a fall through different mechanisms. Based on the World Health Organization global database, the main objective of this study is to investigate the association between heart failure pharmacological treatments and the report of a fall in the database. A disproportionality analysis will be performed. It will aim to assess whether some classes of heart failure drugs, and within these classes some individual drugs, are associated with a report of a fall. A sensibilty analysis will also be performed. It will aim to examine the association between takien a heart failure pharmacological treatment, with a heat failure indication and/or a loop diuretic, and the report of a fall.

Conditions

Heart Failure; Fall

Keywords

Heart failure; Falls; Pharmacological treatments

Outcome Measures

Primary Outcomes (1)

• Report of a fall with a recommended pharmacological treatment for heart failure

  02/11/2024

Secondary Outcomes (1)

• Sensibility analysis

  02/11/2024

Interventions

Heart failure pharmacological treatments DRUG

Identify a positive signal for fall with one or more of the recommended pharmacological treatments for heart failure

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged 65 years and over who presented fall with one or more recommended heart failure drugs

You may qualify if:

• Age 65 years of older

Sponsors & Collaborators

• University Hospital, Caen: lead

Study Sites (1)

Caen University Hospital, Department of Pharmacology

Caen, Normandy, 14000, France

Location

MeSH Terms

Conditions

Heart Failure

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 25, 2025
• First Posted: September 2, 2025
• Study Start: November 2, 2024
• Primary Completion: April 1, 2025
• Study Completion: July 1, 2025
• Last Updated: September 2, 2025

Record last verified: 2025-08

Locations

FR (1)