Effects of HIIT on Muscle Strength, Atrophy and Aerobic Capacity in Stroke Patients.

NCT06292442 | Completed

• 1 other identifier: REC/RCR&AHS/23/0237
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

To determine the effects of High-Intensity Interval Training on muscle strength, atrophy, and aerobic capacity in stroke patients.

Conditions

Stroke

Keywords

aerobic capacity, chronic stroke, high-intensity interval training, muscle atrophy, muscle strength, stroke

Outcome Measures

Primary Outcomes (4)

• Muscle strength

  Manual Muscle Testing is a test that is used to assess muscle strength.

  4th week

• Muscle Atrophy

  Measuring tape is used to measure the calf circumference to measure the atrophy, muscle size over time.

  4th week

• 6-Minute Walk Test (6MWT)

  6-Minute Walk Test (6MWT) used to measure Functional capacity, aerobic fitness and endurance.

  4th week

• Aerobic Capacity

  Harvard Step Test is used to measure Functional capacity, aerobic fitness and endurance.

  4th week

Secondary Outcomes (1)

• Fastest Gait Speed

  4th week

Study Arms (2)

Traditional physical therapy

ACTIVE COMPARATOR

This group received conventional physical therapy treatment including Range of Motion (ROM) exercises for the affected hip, knee, and ankle joints, as well as stretching exercises for tight lower limb muscles, administered 3 times per week for 4 weeks, with each session lasting approximately 20-30 minutes.

Other: traditional physical therapy

High intensity interval training

EXPERIMENTAL

This group received high-intensity interval training along with conventional treatment for the lower limb muscles

Other: High intensity interval training

Interventions

traditional physical therapy OTHER

This group received conventional physical therapy treatment including Range of Motion (ROM) exercises for the affected hip, knee, and ankle joints, as well as stretching exercises for tight lower limb muscles, administered 3 times per week for 4 weeks, with each session lasting approximately 20-30 minutes.

Traditional physical therapy

High intensity interval training OTHER

This group received High Intensity interval training along with conventional treatment for lower limb muscles, performed 3 times per week fr 4 weeks.

High intensity interval training

Eligibility Criteria

• Age: 40 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Both males and females were included
• aged 40-60 years
• Chronic stroke patients who experienced a first-ever ischemic stroke
• Stable cardiovascular condition (American Heart Association class B)
• Physician clearance to participate in a 4-week HIIT program
• No prior structured exercise in the last 3 months
• Ability to walk 10 m over ground with or without assistive devices
• Patients who scored \>24/30 on MMSE (Mini-Mental State Examination)

You may not qualify if:

• Patients who were hospitalized for cardiac or pulmonary disease within the past 3 months
• Patients who had implanted pacemaker or defibrillator
• Patients having conditions where VO2peak assessment is contraindicated, such as uncontrolled hypertension(\>180/100), severe aortic stenosis, acute myocarditis, recent myocardial infarction, or other acute cardiovascular events within the past three months, were excluded from the study
• Patients with severe lower limb spasticity (Ashworth Scale scores \>2 of 4 for knee flexion, knee extension, or ankle dorsiflexion)
• Pregnant females
• Previous exposure to fast treadmill walking in the past year

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Jinnah Hospital, Lahore

Lahore, Punjab Province, 54000, Pakistan

Location

Related Publications (10)

• Hugues N, Pellegrino C, Rivera C, Berton E, Pin-Barre C, Laurin J. Is High-Intensity Interval Training Suitable to Promote Neuroplasticity and Cognitive Functions after Stroke? Int J Mol Sci. 2021 Mar 16;22(6):3003. doi: 10.3390/ijms22063003.

  PMID: 33809413 BACKGROUND

• Gjellesvik TI, Becker F, Tjonna AE, Indredavik B, Lundgaard E, Solbakken H, Brurok B, Torhaug T, Lydersen S, Askim T. Effects of High-Intensity Interval Training After Stroke (The HIIT Stroke Study) on Physical and Cognitive Function: A Multicenter Randomized Controlled Trial. Arch Phys Med Rehabil. 2021 Sep;102(9):1683-1691. doi: 10.1016/j.apmr.2021.05.008. Epub 2021 Jun 6.

  PMID: 34102144 BACKGROUND

• Krawcyk RS, Vinther A, Petersen NC, Faber J, Iversen HK, Christensen T, Klausen TW, Kruuse C. High-intensity training in patients with lacunar stroke: A one-year follow-up. J Stroke Cerebrovasc Dis. 2023 Apr;32(4):106973. doi: 10.1016/j.jstrokecerebrovasdis.2022.106973. Epub 2023 Jan 7.

  PMID: 36623990 BACKGROUND

• Boyne P, Billinger SA, Reisman DS, Awosika OO, Buckley S, Burson J, Carl D, DeLange M, Doren S, Earnest M, Gerson M, Henry M, Horning A, Khoury JC, Kissela BM, Laughlin A, McCartney K, McQuaid T, Miller A, Moores A, Palmer JA, Sucharew H, Thompson ED, Wagner E, Ward J, Wasik EP, Whitaker AA, Wright H, Dunning K. Optimal Intensity and Duration of Walking Rehabilitation in Patients With Chronic Stroke: A Randomized Clinical Trial. JAMA Neurol. 2023 Apr 1;80(4):342-351. doi: 10.1001/jamaneurol.2023.0033.

  PMID: 36822187 BACKGROUND

• Miller A, Reisman DS, Billinger SA, Dunning K, Doren S, Ward J, Wright H, Wagner E, Carl D, Gerson M, Awosika O, Khoury J, Kissela B, Boyne P. Moderate-intensity exercise versus high-intensity interval training to recover walking post-stroke: protocol for a randomized controlled trial. Trials. 2021 Jul 16;22(1):457. doi: 10.1186/s13063-021-05419-x.

  PMID: 34271979 BACKGROUND

• Anjos JM, Neto MG, Dos Santos FS, Almeida KO, Bocchi EA, Lima Bitar YS, Duraes AR. The impact Of high-intensity interval training On functioning And health-related quality Of life In post-stroke patients: A systematic review With meta-analysis. Clin Rehabil. 2022 Jun;36(6):726-739. doi: 10.1177/02692155221087082. Epub 2022 Mar 15.

  PMID: 35290104 BACKGROUND

• Boyne P, Miller A, Schwab SM, Sucharew H, Carl D, Billinger SA, Reisman DS. Training parameters and longitudinal adaptations that most strongly mediate walking capacity gains from high-intensity interval training post-stroke. medRxiv [Preprint]. 2023 Feb 23:2023.02.20.23286194. doi: 10.1101/2023.02.20.23286194.

  PMID: 36865178 BACKGROUND

• Hsu CC, Fu TC, Huang SC, Chen CP, Wang JS. Increased serum brain-derived neurotrophic factor with high-intensity interval training in stroke patients: A randomized controlled trial. Ann Phys Rehabil Med. 2021 Jul;64(4):101385. doi: 10.1016/j.rehab.2020.03.010. Epub 2020 May 11.

  PMID: 32344098 BACKGROUND

• Boyne P, Doren S, Scholl V, Staggs E, Whitesel D, Carl D, Shatz R, Sawyer R, Awosika OO, Reisman DS, Billinger SA, Kissela B, Vannest J, Dunning K. Preliminary Outcomes of Combined Treadmill and Overground High-Intensity Interval Training in Ambulatory Chronic Stroke. Front Neurol. 2022 Feb 4;13:812875. doi: 10.3389/fneur.2022.812875. eCollection 2022.

  PMID: 35185766 BACKGROUND

• Plummer P. Critically appraised paper: High-intensity interval training after stroke improves some aspects of physical function, but benefits are not sustained. J Physiother. 2022 Jul;68(3):204. doi: 10.1016/j.jphys.2022.05.014. Epub 2022 Jun 14. No abstract available.

  PMID: 35715374 BACKGROUND

MeSH Terms

Conditions

Stroke; Muscular Atrophy

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Neuromuscular Manifestations; Neurologic Manifestations; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Binash Afzal, PHD*

  Riphah international university lahore campus

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 28, 2024
• First Posted: March 5, 2024
• Study Start: September 1, 2023
• Primary Completion: October 1, 2023
• Study Completion: November 1, 2023
• Last Updated: March 5, 2024

Record last verified: 2024-03

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)