Evaluating the Implementation and Effectiveness of the Pink and Pearl Campaign on Lung Cancer Screening at Christian Hospital

NCT07146568 | Recruiting

• 1 other identifier: 202508075
• Study Type: interventional
• Target: 5,515
• Locations: 1 country
• Sites: 1

Brief Summary

Inspired by the ongoing Pink \& Pearl Campaign, the breast radiology service of Christian Hospital in north St. Louis County will partner with Siteman Cancer Center to pilot this campaign in its mammography clinics in order to promote awareness, referral, and completion of lung cancer screening (LCS) among eligible women. This campaign leverages established infrastructure such as nurse navigation and referral to screening or primary care for further shared decision-making on cancer screening. The purpose of this study is to evaluate the effectiveness of the Pink \& Pearl Campaign in improving LCS uptake among LCS-eligible women undergoing mammography at Christian Hospital. This evaluation is grounded in the Integrated Screening Action Model that depicts individual- and environmental-level influences on the screening behavior process. Using an explanatory sequential mixed methods design, which combines both quantitative and qualitative approaches, our specific aims for this proposal are to: a) assess whether the Pink \& Pearl Campaign increases referrals and uptake/completion of LCS among LCS-eligible women undergoing screening mammography; b) determine median time-to-screening after referral to LCS; and c) evaluate individual and health system factors influencing LCS uptake and implementation outcomes of the campaign. These implementation outcomes will help identify whether the campaign was put in place successfully or not. This proposal will inform strategies for integrating cancer screening programs to improve poorly performing programs like LCS.

Conditions

Lung Cancer; Cancer of the Lung

Keywords

Lung cancer screening (LCS); Pink and Pearl Campaign; Breast cancer screening (BCS); Low-dose computed tomography (LDCT); Smoking history; Health disparities; Screening behavior; Feasibility; Acceptability; Appropriateness

Outcome Measures

Primary Outcomes (1)

• Proportion of women referred from the breast radiology service who successfully complete LCS 6-months post-Pink & Pearl implementation

  The investigators will compare the baseline prevalence of LCS among women undergoing BCS to the prevalence of LCS among women undergoing BCS 6 months after implementation of the Pink \& Pearl Campaign.

  At 6 months

Secondary Outcomes (2)

• Median time-to-screening

  At 6 months

• Acceptability of Pink & Pearl Campaign

  At 6 months

Other Outcomes (4)

• Number of individual level barriers to LCS completion

  At 6 months

• Number of health system level barriers to LCS completion

  At 6 months

• Feasibility of Pink & Pearl Campaign

  At 6 months

Study Arms (2)

Participants - scheduled for mammography and eligible for LCS

EXPERIMENTAL

All women coming in for breast cancer screening will be assessed for LCS eligibility using a screening questionnaire administered by mammography technicians. Patients who are determined to be eligible for LCS will be asked by the mammography technician if they will opt into being contacted by the nurse navigator, who will facilitate their referral to primary care to schedule a LCS appointment at Siteman Cancer Center.

Other: Pink and Pearl Campaign

Providers

NO INTERVENTION

Providers in the breast radiology service who referred women to LCS. Investigators will gather information on the feasibility, acceptability, and appropriateness of the Pink and Pearl project.

Interventions

Pink and Pearl Campaign OTHER

This campaign leverages established infrastructure such as nurse navigation and referral to screening or primary care for further shared decision-making on cancer screening.

Participants - scheduled for mammography and eligible for LCS

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

Eligibility Criteria - Interventional Study * Undergoing screening mammography at Christian Hospital * Between the ages of 50-80 years (inclusive) Eligibility Criteria - Survey and Interview Sub-Studies * Part of the interventional study * Reporting a 20 pack-year equivalent of either current smoking history or have quit in the past 15 years * Can speak and understand English * Not diagnosed with a serious health problem that will limit life expectancy (such as previous history of lung cancer, symptoms of lung cancer such as hemoptysis or unexplained weight loss of more than 6.8 kg (15 lb) in the previous year) * Willing and able to get treatment if lung cancer is found * Able to understand and willing to sign an IRB-approved written informed consent document Eligibility Criteria - Providers * At least 20 years of age * Involved in the breast radiology service or referred at least one patient to the Pink \& Pearl Campaign * Able to provide verbal consent to participate in the interview

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Washington University School of Medicine: lead

Study Sites (1)

Barnes-Jewish Christian Hospital

St Louis, Missouri, 63136, United States

RECRUITING

Related Links

• Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine

MeSH Terms

Conditions

Lung Neoplasms

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Beryne Odeny, M.D., MPH, Ph.D.

  Washington University School of Medicine

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Beryne Odeny, M.D., MPH, Ph.D.

CONTACT

314-362-1183; beryne@wustl.edu

Michelle V Lee, M.D.

CONTACT

314-454-7405; lee.michelle@wustl.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 21, 2025
• First Posted: August 28, 2025
• Study Start: February 23, 2026
• Primary Completion (Estimated): August 31, 2026
• Study Completion (Estimated): August 31, 2026
• Last Updated: February 24, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP
• Time Frame: For a period of 1 year.
• Access Criteria: Contact the Principal Investigator or Central Contact Back-up via email.

Locations

US (1)