Standardization of Spatial Neglect Assessment Tests

NCT07145970 | Recruiting

• 1 other identifier: APHP250520
• Study Type: interventional
• Target: 210
• Locations: 1 country
• Sites: 1

Brief Summary

Spatial neglect is a common cognitive disorder in stroke patients, characterized by a lateralized deficit in attention and intention. This research focuses on defining norms for tests to assess spatial neglect. The norms correspond to the results obtained in a population free of any disorder that could have an impact on test performance. These results can vary in a normal, non-pathological way, with certain parameters such as age, sex, laterality or level of education. Defining these norms in healthy volunteers is therefore essential for interpreting results in patients suspected of spatial neglect, and in particular for defining pathological thresholds above which the diagnosis of spatial neglect can be retained. To answer the research question, we plan to include 210 people with no central neurological disease (stroke, epilepsy and multiple sclerosis in particular), in a single-center study in the neurovascular department of the Raymond-Poincaré hospital (Garches). The 210 subjects will be divided into 10-year age groups, from 20 to 89 years, with the recruitment of 30 participants per age group (15 men and 15 women): 20-29 years, 30-39 years, 40-49 years, 50-59 years, 60-69 years, 70-79 years, 80-89 years.

Conditions

Perceptual Disorders; Healthy Volunteers; Reference Values

Keywords

Spatial neglect; Tactile neglect; Visual neglect; Directional motor neglect

Outcome Measures

Primary Outcomes (1)

• To establish average scores for healthy French-speaking volunteers without central neurological disorders on the Apples Cancellation Test (from the BCoS), using French-translated administration and scoring instructions

  The average scores for healthy French-speaking volunteers without central neurological disorders on the Apples Cancellation Test (from the BCoS), using French-translated administration instructions. The number of the box in which the first crossed-out apple is located, the total performance, the spatial asymmetry score (egocentric neglect), the object asymmetry score (allocentric neglect) and the passing time, in seconds.

  12 months

Secondary Outcomes (3)

• To establish average scores for healthy French-speaking volunteers without central neurological disorders on the simplified Comb and Razor Test, using French-language administration instructions

  inclusion

• To establish average scores for healthy French-speaking volunteers without central neurological disorders on the Peg Test, according to their age, sex, and level of occupational qualification.

  inclusion

• To establish average scores for healthy French-speaking volunteers without central neurological disorders on the 30 cm blind line bisection test using an architect's ruler, according to their age, sex, and level of occupational qualification.

  inclusion

Study Arms (1)

group

EXPERIMENTAL

Other: Neuropsychological assessment tests for spatial neglect

Interventions

Neuropsychological assessment tests for spatial neglect OTHER

Standardized administration of four paper-and-pencil tests designed to assess different forms of spatial neglect: * Apples Cancellation Test (Birmingham Cognitive Screen) for egocentric and allocentric neglect, * Simplified Comb and Razor Test for personal and motor neglect, * Line Bisection Test (30 cm ruler, blind version) for tactile neglect, * Dot Test for visual exploration. The purpose is to establish normative reference scores in healthy French-speaking adults according to age, sex, and professional qualification. No therapeutic intervention or patient population is involved.

group

Eligibility Criteria

• Age: 20 Years - 89 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy volunteer attending the neurovascular department of Raymond-Poincaré Hospital
• Aged between 20 and 89 years
• Affiliated with a health insurance scheme
• French-speaking
• Has freely and knowingly expressed their non-opposition

You may not qualify if:

• Known history of central neurological disease: stroke (ischemic or hemorrhagic), transient ischemic attack, encephalitis, multiple sclerosis, or epilepsy.
• Medical interview suggesting past central nervous system involvement: history of episodes such as sensorimotor deficits, dysarthria, aphasia, blurred or double vision, or positive symptoms such as visual or sensory hallucinations (e.g., paresthesias).
• Significant visual impairment - as judged by the examiner - in near vision despite correction, or monocular blindness. Specifically, inability to distinguish the targets with gaps in the example (pre-test) of the Apples Cancellation Test.
• Abnormal neurological examination:
• National Institutes of Health Stroke Scale (NIHSS) score \> 0
• Pyramidal reflex syndrome (hyperactive deep tendon reflexes with extended reflexogenic zones and spread).
• Use of substances (alcohol or drugs) within 24 hours prior to the assessment.
• Participant under legal protection (guardianship, curatorship, or legal safeguard).

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead

Study Sites (1)

CHU Raymond Poincarré

Garche, 92380, France

RECRUITING

MeSH Terms

Conditions

Perceptual Disorders

Condition Hierarchy (Ancestors)

Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Jean-Baptiste BRUNET de COURSSOU, Dr

CONTACT

+33 1 47 10 72 55; jean-baptiste.brunet-de-courssou@aphp.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 20, 2025
• First Posted: August 28, 2025
• Study Start: January 7, 2026
• Primary Completion (Estimated): January 7, 2027
• Study Completion (Estimated): January 7, 2027
• Last Updated: February 10, 2026

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)