Assessment of Physical Activity, Balance, Muscle Strength, and Cognitive Function in Patients Diagnosed With Schizophrenia

NCT07141966 | Completed

• 1 other identifier: Ismail KKoc
• Study Type: observational
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

Schizophrenia is a serious mental health condition that affects individuals' thinking, perception, emotional responses, and behavior. Balance in schizophrenia patients is often related to motor skills, coordination, and postural control. Schizophrenia can cause functional changes in certain areas of the brain. These changes can affect motor functions. Balance loss in schizophrenia patients can cause difficulties in daily living activities, increased risk of falls, and a decrease in overall quality of life. Therefore, the aim of this study is to evaluate physical activity, balance, muscle strength, and cognitive function in patients diagnosed with schizophrenia.

Conditions

Schizophrenia Disorder

Outcome Measures

Primary Outcomes (4)

• International Physical Activity Questionnaire (IPAQ):

  Used to assess an individual's physical activity level over the past 7 days. The International Physical Activity Questionnaire (IPAQ) consists of 4 questionnaires. There are long (5 independently asked activity areas) and short (4 general items) versions. The short version consists of questions about the time spent walking and engaging in moderate to vigorous and strenuous activities.

  2 weeks

• Berg Balance Scale

  Berg Balance Scale The scale, consisting of a total of 14 items, assesses patients' balance skills. Each item is scored on a scale of 0-4. 0 = unable to perform, 4 = normal performance. The maximum score is 56, and a high score indicates better balance skills. The physical therapist administers the test by providing the necessary instructions to the patient in a manner they can understand after the patient has rested. The choice of which foot to use in certain items should be left to the patient. The materials required for the test (stopwatch, measuring tape, chair, step, slippers) should be prepared before beginning the assessment.

  2 weeks

• Handgrip Strength

  Handgrip strength was assessed using the JTech Commander GripTrack™ hand dynamometer. Participants performed the measurement according to a standardized testing procedure, and grip strength was recorded in kilograms (kg). Higher values indicate greater handgrip strength.

  2 weeks

• Mini Mental State Examination

  The standardized version of the MMSE (Mini Mental State Examination) developed by Folstein et al. (1975) was adapted by Molloy and Standish (1997). The MMSE allows for cognitive assessment in a short period of time. In this regard, the MMSE is a short, easy-to-administer, and standardized test used to assess global cognitive level. The test is widely used to evaluate the cognitive status of elderly individuals. A validity and reliability study in the Turkish population was conducted by Güngen and colleagues (2002). In their study, Güngen and colleagues (2002) determined that the 23/24 cutoff value of the Standardized Mini Mental Test (SMMT) had a sensitivity of 0.91, a specificity of 0.95, an inter-rater reliability of r:0.99, and a kappa value of 0.92. As a result, it was determined that the Standardized Mini Mental Test is valid and reliable in the Turkish population.

  2 weeks

Study Arms (1)

patients with schizophrenia

patients with schizophrenia

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with Schizophrenia

You may qualify if:

• Diagnosis of schizophrenia by a psychiatrist according to DSM-V
• aged between 18 and 65 years
• being clinically stable
• having received continuous pharmacological treatment for at least six months
• having the ability to understand and follow verbal and written instructions

You may not qualify if:

• major neurological disorders (e.g. epilepsy or Parkinson's disease)
• significant orthopaedic impairments affecting balance or strength
• substance use disorders (except nicotine)
• acute psychotic symptoms and severe intellectual disability

Sponsors & Collaborators

• Dr. Lutfi Kirdar Kartal Training and Research Hospital: lead

Study Sites (1)

Kartal Dr Lütfi Kırdar City Hospital

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Schizophrenia

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Prof

Study Record Dates

• First Submitted: August 19, 2025
• First Posted: August 26, 2025
• Study Start: August 19, 2025
• Primary Completion: August 30, 2025
• Study Completion: September 15, 2025
• Last Updated: August 19, 2026

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)