The Effect of Perioperative Hyperglycemia on Anastomotic Leaks After Total Gastrectomy

NCT07140991 | Completed

• 1 other identifier: 2025-183
• Study Type: observational
• Target: 102
• Locations: 1 country
• Sites: 1

Brief Summary

Esophagojejunostomy anastomosis is used in total gastrectomy surgeries. Anastomotic leakage is a serious complication seen after these surgeries and is associated with increased morbidity and mortality. Patients with older age and comorbidities have a higher risk of death following anastomotic leakage. Perioperative hyperglycemia is frequently observed in patients undergoing major abdominal surgery as a stress response to surgical trauma, leading to surgical complications through mechanisms such as glycogenolysis, lipolysis, gluconeogenesis, decreased insulin sensitivity, and increased insulin resistance. Hyperglycemia is known to increase the risk of postoperative infection, prolong hospital stay, and increase mortality. Additionally, recent studies have shown that it also increases the risk of anastomotic leakage.

Conditions

Hyperglycaemia; Total Gastrectomy; Anastomotic Leaks

Keywords

hyperglycaemia; total gastrectomy; anastomotic leak

Outcome Measures

Primary Outcomes (1)

• postoperative anastomotic leakage

  Patients who developed anastomotic leak after total gastrectomy

  30 days after surgery

Secondary Outcomes (2)

• diabetic hyperglysemia

  intraoperative

• non-diabetic hyperglysemia

  intraoperative

Study Arms (1)

hyperglycemia

Patients identified as hyperglycemic in the perioperative period

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study was planned as a single-center retrospective study involving patients between the ages of 18 and 75 who underwent total gastrectomy and esophago-jejunostomy anastomosis for benign or malignant reasons.

You may qualify if:

• elective total gastrectomy
• anastomotic leak after surgery
• age 18-75

You may not qualify if:

• emergency procedure
• \<18 years
• \>75 years
• ASA score \> 3

Sponsors & Collaborators

• Taner Abdullah: lead

Study Sites (1)

Basaksehir Cam ve Sakura City Hospital

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Hyperglycemia; Anastomotic Leak

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Mustafa Çağrı Temel, MD

  Basaksehir Cam ve Sakura State Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: August 21, 2025
• First Posted: August 26, 2025
• Study Start: June 1, 2025
• Primary Completion: July 20, 2025
• Study Completion: August 20, 2025
• Last Updated: August 26, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)