A Multi-center Study on Artificial Intelligence-Based Quantitative Evaluation of Echocardiography
MAIQUEE
1 other identifier
observational
1,600
1 country
37
Brief Summary
This project aims to collaborate with multiple medical institutions to verify the accuracy, stability, and clinical application value of AI algorithms in echocardiographic quantitative measurement through multi-center clinical research. Specific objectives include:
- 1.Compare the automatic measurement results of AI with the manual measurement data from physicians of different levels, and analyze the measurement deviation and consistency of AI in key parameters such as intracardiac diameter, volume, and function.
- 2.Investigate whether AI-assisted measurement can significantly reduce echocardiogram analysis time and optimize clinical workflows. Through multi-center data validation, establish a standardized reference system for AI ultrasound measurement, promote the promotion and application of AI technology in medical institutions at all levels, and reduce diagnostic differences between different hospitals and physicians.
- 3.Exploring the application of AI in special cases: Assessing the measurement stability of AI algorithms in complex cases (such as cardiomyopathy, valvular disease, coronary heart disease, etc.), and optimizing AI models to meet broader clinical needs.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jul 2025
Shorter than P25 for all trials
37 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 22, 2025
CompletedFirst Submitted
Initial submission to the registry
July 30, 2025
CompletedFirst Posted
Study publicly available on registry
August 21, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
July 31, 2026
August 21, 2025
August 1, 2025
11 months
July 30, 2025
August 18, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
The indicators of left ventricular size and function are measured by AI, senior physicians at the PI unit, and intermediate physicians at each sub center respectively (all parameters are measured by Mindray ultrasonic machines on the machine)
Left ventricular end diastolic volume (EDV, ml), end systolic volume (ESV, ml), and ejection fraction (EF, %) (calculated by (EDV-ESV)/EDV\*100% ) in the four chamber view and two chamber view, as well as the Simpson biplane left ventricular volume (ml) and ejection fraction (%) results.
Artificial intelligence and intermediate doctors measurement results of each sub center will be completed within one day after data collection. Senior physicians measurement results of PI unit will be completed within one month after data collection.
The indicator of right ventricular function is measured by AI, senior physicians at the PI unit, and intermediate physicians at each sub center respectively (all parameters are measured by Mindray ultrasonic machines on the machine)
Right ventricular area change rate calculated by (EDA-ESA)/EDA\*100%.
Artificial intelligence and intermediate doctors measurement results of each sub center will be completed within one day after data collection. Senior physicians measurement results of PI unit will be completed within one month after data collection.
The indicators of right ventricular size are measured by AI, senior physicians at the PI unit, and intermediate physicians at each sub center respectively (all parameters are measured by Mindray ultrasonic machines on the machine)
Right ventricular end diastolic area (EDA) and end systolic area (ESA).
Artificial intelligence and intermediate doctors measurement results of each sub center will be completed within one day after data collection. Senior physicians measurement results of PI unit will be completed within one month after data collection.
Secondary Outcomes (2)
Doppler ultrasound measurement indicators by are measured by AI, senior physicians at the PI unit, and intermediate physicians at each sub center respectively (all parameters are measured by Mindray ultrasonic machines on the machine)
Artificial intelligence and intermediate doctors measurement results of each sub center will be completed within one day after data collection. Senior physicians measurement results of PI unit will be completed within one month after data collection.
Mitral valve annulus and tricuspid valve annulus displacement are measured by AI, senior physicians at the PI unit, and intermediate physicians at each sub center respectively (all parameters are measured by Mindray ultrasonic machines on the machine)
Artificial intelligence and intermediate doctors measurement results of each sub center will be completed within one day after data collection. Senior physicians measurement results of PI unit will be completed within one month after data collection.
Study Arms (3)
AI group
The cardiac chamber size and functional parameters of all 1600 subjects were measured by AI
Senior physician group
The cardiac chamber size and functional parameters of all 1600 subjects were measured by senior physicians at the PI unit
Intermediate physician group
The cardiac chamber size and functional parameters of all 1600 subjects were measured by intermediate physicians at each sub center
Eligibility Criteria
Patients who require cardiac ultrasound examination for various reasons in clinical practice. Ultrasound and clinical diagnosis of patients with normal cardiac structure and function, as well as those with coronary heart disease, valve disease, hypertensive heart disease, atrial fibrillation, heart failure, dilated cardiomyopathy, and hypertrophic cardiomyopathy. A total of 1600 adults were enrolled in multiple centers;
You may qualify if:
- Age ≥18 - 80 years;
- Types of diseases (8 in total, 200 cases each):
- Normal heart
- Coronary heart disease (with segmental thinning and abnormal movement)
- Valve disease (valve stenosis or reflux)
- Hypertensive heart disease
- Atrial fibrillation
- Heart failure
- Dilated cardiomyopathy
- Hypertrophic cardiomyopathy
You may not qualify if:
- Patients with congenital heart disease
- Patients with poor image quality
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (37)
Huainan First People's Hospital
Huainan, Anhui, China
Union Hospital Affiliated to Fujian Medical University
Fuzhou, Fujian, China
Meizhou People's Hospital
Meizhou, Guangdong, China
Shantou Central Hospital
Shantou, Guangdong, China
Shenzhen Hospital of Fuwai Hospital
Shenzhen, Guangdong, China
Shenzhen People's Hospital
Shenzhen, Guangdong, China
Affiliated Hospital of Youjiang Medical University for Nationalities
Baise City, Guangxi, China
Guilin Hospital of Traditional Chinese Medicine
Guilin, Guangxi, China
The Fourth Affiliated Hospital of Guangxi Medical University / Liuzhou Workers' Hospital
Liuchow, Guangxi, China
Yulin First People's Hospital
Yulin, Guangxi, China
The Second Affiliated Hospital of Zunyi Medical University
Zunyi, Guizhou, China
Haikou People's Hospital
Haikou, Hainan, China
The Second Affiliated Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China
Loudi First People's Hospital
Loudi, Hunan, China
Hunan Province Directly Affiliated TCM Hospital
Zhuzhou, Hunan, China
Baotou No.4 Hospital
Baotou, Inner Mongolia, China
Shangrao Central Hospital
Shangrao, Jiangxi, China
Shangrao People's Hospital
Shangrao, Jiangxi, China
Ansteel Group General Hospital
Anshan, Liaoning, China
Chaoyang Central Hospital
Chaoyang, Liaoning, China
Fushun Central Hospital
Fushun, Liaoning, China
Shengjing Hospital of China Medical University
Shenyang, Liaoning, China
The First Hospital of China Medical University
Shenyang, Liaoning, China
Qinghai Provincial Hospital of Cardiovascular and Cerebrovascular Diseases
Xining, Qinghai, China
The Central Hospital Affiliated to Shandong First Medical University
Tai’an, Shandong, China
Linfen People's Hospital
Linfen, Shanxi, China
The Second Affiliated Hospital of Xi'an Jiaotong University
Xi’an, Shanxi, China
Jiangyou 903 Hospital
Jiangyou, Sichuan, China
Bishan Hospital Affiliated to Chongqing Medical University
Chongqing, China
Bishan Hospital Affiliated to Chongqing University of Chinese Medicine (Chongqing Bishan District Hospital of Traditional Chinese Medicine)
Chongqing, China
Chongqing Hospital of Traditional Chinese Medicine
Chongqing, China
Chongqing People's Hospital
Chongqing, China
Fuling Hospital Affiliated to Chongqing University
Chongqing, China
The First Affiliated Hospital of Army Medical University
Chongqing, China
The Second Affiliated Hospital of Chongqing Medical University
Chongqing, China
Shanghai Changzheng Hospital
Shanghai, China
MeSH Terms
Conditions
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Chief of Cardiovascular Ultrasound
Study Record Dates
First Submitted
July 30, 2025
First Posted
August 21, 2025
Study Start
July 22, 2025
Primary Completion (Estimated)
June 30, 2026
Study Completion (Estimated)
July 31, 2026
Last Updated
August 21, 2025
Record last verified: 2025-08