Structural Brain Volumetry Changes in Eating Disorders.

NCT07131852 | Not Yet Recruiting

• 1 other identifier: 645210
• Study Type: observational
• Target: 80
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this observational study is to investigate the relationship between structural brain changes and psychiatric comorbidities in individuals diagnosed with eating disorders (EDs). The main question it aims to answer is: How are structural brain volumetric changes associated with psychiatric comorbidities in patients with eating disorders? Participants with a clinical diagnosis of an eating disorder will undergo brain MRI scans for volumetric analysis and structured psychiatric assessments to identify comorbid conditions. Data will be collected cross-sectionally from patients receiving routine clinical care, with the aim of identifying neurobiological and psychiatric patterns that could inform targeted treatment and prevention strategies.

Conditions

Eating Disorders; Psychiatric Comorbidities

Keywords

Eating Disorders; Anorexia Nervosa; Binge eating disorders; bulimia disorders

Outcome Measures

Primary Outcomes (1)

• To assess structural changes of brain volumetry in patients with eating disorders and compare with healthy controls.

  from enrollment till 18 months

Secondary Outcomes (1)

• Highlight the extent of psychological disorders in such patients.

  From enrollment till 18 months

Study Arms (4)

Anorexia Nervosa Patients

Bulimia Nervosa Patients

Binge-Eating Disorder

control group

Eligibility Criteria

• Age: 13 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Study Setting: in Assuit university hospitals, Neuropsychiatry hospital Outpatient Clinic Study subjects: will include three groups of patients with eating disorders: Anorexia nervosa patients, Bulimia Nervosa patients, Binge-eating patients, and healthy control group they will be age and sex matched.

You may qualify if:

• Age above 13 years.
• DSM-5 diagnosis of an eating disorder (AN, BN, BED) confirmed by structured interview.

You may not qualify if:

• Neurological or any previous psychiatric diagnosis.
• IQ less than 70.
• MRI contraindication (metal implants, pacemaker, severe claustrophobia).

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Feeding and Eating Disorders; Anorexia Nervosa; Binge-Eating Disorder

Condition Hierarchy (Ancestors)

Signs and Symptoms, Digestive; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders

Central Study Contacts

Alya O Mohamed, Master's degree

CONTACT

+20100859567; alya.ali268@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Lecturer

Study Record Dates

• First Submitted: August 13, 2025
• First Posted: August 20, 2025
• Study Start: December 10, 2025
• Primary Completion (Estimated): February 20, 2027
• Study Completion (Estimated): May 20, 2027
• Last Updated: August 20, 2025

Record last verified: 2025-08