Psychiatric Comorbidities in Children With Generalized Epilepsy

NCT06194422 | Unknown

• 1 other identifier: psychiatric change in children
• Study Type: observational
• Target: 62
• Locations: 0 countries
• Sites: N/A

Brief Summary

Epilepsy is defined as a chronic disorder that presents with recurrent episodes of unprovoked seizures. Epileptic seizures are caused by excessive excitation of cortical neurons. The condition has various etiologies and comorbidities. Classification; The Classification of Epilepsies includes several diagnostic levels (steps):

1. 1.from seizure type to epilepsy type (generalized/focal/combined generalized and focal/unknown)
2. 2.etiology (genetic/ structural/ infectious/ metabolic/ immune/unknown). A clinician can use any level of the classification

Conditions

Psychiatric Comorbidities

Outcome Measures

Primary Outcomes (1)

• Psychiatric comorbidities in children with generalized epilepsy

  Measuring the prevalence of ADHD and Autism among children suffering from generalized epilepsy .All cases included in the study will be evaluated by: * full history including neurological history . * full examination including neurological examination . * Investigations: * EEG * ADHD Symptom Checklist-4 (ADHD-SC4( \[8\] * Gilliam Autism Rating scale ( GARS) \[9\] Sample size calculation: Based on determining the main outcome variable, the estimated minimum required total sample size is 62 participants . Main outcome variable: to evaluate phsycatric complications among epilitic pediatric patients. based on previous study, (40%) and (11-30%) ADHD and Autisim In epilitic children respectively . \[10-11\] Main statistical test is chi square to detect the difference in percentage of physiatric disorders( ADHD and Autism) in the two groups . Alpha error = 0.05 Power = 0.80 Allocation ratio= 1 One tailed.

  baseline

Eligibility Criteria

• Age: 6 Years - 17 Years
• Sex: all
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

psychiatric comorbidities in children with generalized epilepsy

You may qualify if:

• Patients with generalized epilepsy either new or old ,controlled or un controlled .
• School aged patients (from 6 years to 17 years).
• Patients on anti epileptic treatment .
• Patients attending children's neurological unit .

You may not qualify if:

• \- children with other types of epilepsy .
• children with cerebral palsy.
• children with neurodegenerative disease.
• children with neurometabolic disease.
• mentally retarded children.

Sponsors & Collaborators

• Assiut University: lead

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident doctor

Study Record Dates

• First Submitted: November 20, 2023
• First Posted: January 8, 2024
• Study Start: December 30, 2023
• Primary Completion: December 31, 2024
• Study Completion: March 24, 2025
• Last Updated: January 8, 2024

Record last verified: 2024-01