Multimodal Imaging Assessment After Revascularization in Patients With Acute Myocardial Infarction

NCT07130409 | Recruiting

• 1 other identifier: QYFYECR2025-74
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective cohort study will enroll 20 patients clinically diagnosed with first-time acute myocardial infarction (AMI) who underwent interventional procedures (including percutaneous coronary intervention \[PCI\] and balloon angioplasty) at the Affiliated Hospital of Qingdao University. Patient data, including routine blood and urine tests, blood biochemistry, electrocardiograms (ECG), imaging studies, and interventional procedure records, will be collected to assess eligibility for enrollment. The study procedures include patient screening and enrollment, obtaining informed consent, baseline assessment (including medical history, laboratory tests, ECG, etc.), an ¹⁸F-Pentixafor PET/MR examination, and follow-up. Images will be blindly assessed by at least two specialized physicians from the Radiology and Nuclear Medicine departments. The study aims to investigate the utility of ¹⁸F-Pentixafor PET/MR in evaluating coronary microcirculatory function, cardiac function, myocardial viability, myocardial inflammatory response, and the efficacy of interventional therapy in AMI patients post-procedure. Additionally, it will perform risk stratification and prognostic analysis for the enrolled patients.

Conditions

Cardiac Magnetic Resonance Imaging; Acute Myocardial Infarction (AMI); PET / MR

Outcome Measures

Primary Outcomes (3)

• The myocardial uptake of 18F-Pentixafor was quantified using SUVmax and SUVmean values derived from PET imaging.

  At baseline (within 1 week of enrollment)

• Left ventricular ejection fraction (LVEF) assessed by cardiac MRI to evaluate left ventricular function

  At baseline (within 1 week of enrollment)

• Infarct Characterization

  Late gadolinium enhancement (LGE) images were used to calculate infarct size (IS).

  At baseline (within 1 week of enrollment)

Secondary Outcomes (3)

• Myocardial T1 Values and Extracellular Volume (ECV)

  At baseline (within 1 week of enrollment)

• Myocardial T2 values

  At baseline (within 1 week of enrollment)

• Myocardial Strain Analysis

  At baseline (within 1 week of enrollment)

Study Arms (1)

clinically diagnosed with first-episode AMI and undergoing interventional therapy

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

clinically diagnosed with first-episode AMI and undergoing interventional therapy

You may qualify if:

• Patients with a clinical diagnosis of first-episode acute myocardial infarction (AMI) who underwent emergency percutaneous coronary intervention (PCI) were included. All patients had complete baseline clinical data, with baseline cardiac magnetic resonance (CMR) examinations performed within 7 days post-PCI and follow-up CMR completed at 6 months post-procedure.

You may not qualify if:

• Patients with severe cardiac decompensation (Killip class 4) or clinically unstable conditions.
• Patients with coexisting valvular heart disease, congenital heart disease, pulmonary hypertension, cardiomyopathy, or persistent atrial fibrillation that may confound cardiac structural/functional assessments.
• Prior history of myocardial infarction, coronary revascularization (PCI/CABG).
• Concurrent severe systemic diseases including hematologic disorders, malignancies, rheumatic/autoimmune diseases, or severe hepatic/renal failure.
• Contraindications to CMR (claustrophobia, pacemaker implantation, etc.).
• Pregnant, breastfeeding, or women of childbearing potential without effective contraception.
• Sexually active individuals of reproductive age unwilling to use reliable contraception.

Sponsors & Collaborators

• The Affiliated Hospital of Qingdao University: lead

Study Sites (1)

The Affiliated Hospital of Qingdao University

Qingdao, Shandong, 266003, China

RECRUITING

Central Study Contacts

Pei Nie, MD

CONTACT

0532-82911500; niepei@qdu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 30, 2025
• First Posted: August 19, 2025
• Study Start: August 1, 2025
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: August 19, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)