Predictors for ACS and Complexity of CAD

NCT07130188 | Not Yet Recruiting

• 1 other identifier: Predictors for ACS
• Study Type: observational
• Target: 130
• Locations: 0 countries
• Sites: N/A

Brief Summary

To evaluate the significance of the Triglyceride index and TG/HDL-C ratio as predictors of acute coronary syndromes in the young population

Conditions

TG Index; TG/HDL-C Ratio; Young Population

Outcome Measures

Primary Outcomes (1)

• Predictive value of TyG index and TG/HDL-C ratio for acute coronary syndrome (ACS) in young adults

  Occurrence of ACS (defined as STEMI, NSTEMI confirmed by clinical assessment, ECG changes, and cardiac biomarkers according to accepted guideline criteria) and the diagnostic/predictive performance of baseline Triglyceride-glucose (TyG) index and TG/HDL-C ratio for ACS.

  On second day of admission

Interventions

PCI DIAGNOSTIC_TEST

Coronary angiography then SYNTAX score calculation

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Young adult patients (18-45 years) admitted with acute coronary syndrome (STEMI, NSTEMI) who undergo coronary angiography during index hospitalization. Patients must have fasting lipid profile and fasting glucose measured within 24 hours of admission. Exclusions include familial hyperlipidemia, chronic inflammatory/autoimmune disease, severe renal or liver failure, active infection, recent use of non-statin lipid-altering drugs, or missing data for TyG/TG-HDL-C calculation. Follow-up will be conducted at 12 and 36 months to assess outcomes.

You may qualify if:

• Age 18-40 years. Confirmed diagnosis of ACS (STEMI, NSTEMI). Willingness to participate with informed consent.

You may not qualify if:

• Age \> 40 years old People with Previous ACS Patients known to have familial hyperlipidemia

Sponsors & Collaborators

• Assiut University: lead

Related Publications (5)

• Kim MK, Ahn CW, Kang S, Nam JS, Kim KR, Park JS. Relationship between the triglyceride glucose index and coronary artery calcification in Korean adults. Cardiovasc Diabetol. 2017 Aug 23;16(1):108. doi: 10.1186/s12933-017-0589-4.

  PMID: 28830471 BACKGROUND

• Khalaji A, Behnoush AH, Pasebani Y, Rafati A, Mahmoodi T, Arzhangzadeh A, Shamshiri Khamene S, MohammadKhawajah I, Mehrani M, Vasheghani-Farahani A, Masoudkabir F, Najafi K, Askari MK, Harrison A, Nelson JR, Hosseini K, Hernandez AV. Triglyceride-glucose index as a predictor of cardiac adverse events in acute coronary syndrome patients undergoing percutaneous coronary intervention: role of diabetes. BMC Cardiovasc Disord. 2024 Sep 27;24(1):514. doi: 10.1186/s12872-024-04191-5.

  PMID: 39333881 BACKGROUND

• Liu Y, Zhu B, Zhou W, Du Y, Qi D, Wang C, Cheng Q, Zhang Y, Wang S, Gao C. Triglyceride-glucose index as a marker of adverse cardiovascular prognosis in patients with coronary heart disease and hypertension. Cardiovasc Diabetol. 2023 Jun 9;22(1):133. doi: 10.1186/s12933-023-01866-9.

  PMID: 37296406 BACKGROUND

• Ren X, Chen ZA, Zheng S, Han T, Li Y, Liu W, Hu Y. Association between Triglyceride to HDL-C Ratio (TG/HDL-C) and Insulin Resistance in Chinese Patients with Newly Diagnosed Type 2 Diabetes Mellitus. PLoS One. 2016 Apr 26;11(4):e0154345. doi: 10.1371/journal.pone.0154345. eCollection 2016.

  PMID: 27115999 BACKGROUND

• da Silva A, Caldas APS, Hermsdorff HHM, Bersch-Ferreira AC, Torreglosa CR, Weber B, Bressan J. Triglyceride-glucose index is associated with symptomatic coronary artery disease in patients in secondary care. Cardiovasc Diabetol. 2019 Jul 11;18(1):89. doi: 10.1186/s12933-019-0893-2.

  PMID: 31296225 BACKGROUND

Study Officials

• Khaled Mohamed Abdallah, Professor

  Assuit university - faculty of medicine

  STUDY DIRECTOR

Central Study Contacts

Saleh Mohamed Saleh, Resident

CONTACT

+201094568705; Saleh.17298603@med.aun.edu.eg

Mohamed Osman Abdelhameed, Lecturer

CONTACT

+201061878040

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: August 12, 2025
• First Posted: August 19, 2025
• Study Start: September 1, 2025
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): December 30, 2026
• Last Updated: August 19, 2025

Record last verified: 2025-08