Living Independence Through Functional Training

NCT07125378 | Recruiting Phase 1

• 1 other identifier: IRB202500835
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 2

Brief Summary

The purpose of the research is to evaluate the feasibility and benefits of a six-week hybrid task-oriented resistance exercise program for older adults who have been recently discharged from home health care.

Conditions

Mobility Limitation; Cognitive Impairment

Keywords

Home-based intervention; Exercise; Older adults; Activities of daily living; Mobility; Cognition

Outcome Measures

Primary Outcomes (2)

• Short Physical Performance Battery

  The score ranges from 0 to 12, with a score of 12 indicating the best physical functioning of the lower extremity.

  Baseline, 8 weeks, and 12 weeks.

• Montreal Cognitive Assessment

  The score ranges from 0 to 30, with a score of 30 indicating the best global cognitive function.

  Baseline, 8 weeks, and 12 weeks.

Secondary Outcomes (8)

• Timed Up and Go Test-Single Task.

  Baseline, 8 weeks, and 12 weeks.

• Timed Up and Go-Dual Task

  Baseline, 8 weeks, and 12 weeks.

• List Sorting Working Memory Test

  Baseline, 8 weeks, and 12 weeks.

• Dimensional Change Card Sort Test

  Baseline, 8 weeks, 12 weeks.

• Flanker Inhibitory Control and Attention Test

  Baseline, 8 weeks, and 12 weeks

Other Outcomes (6)

• Patient Health Questionnaire-9

  Baseline, 8 weeks, 12 weeks.

• Pain, Enjoyment of Life and General Activity Scale

  Baseline, 8 weeks, and 12 weeks.

• Activity Measure for Post-Acute Care to measure everyday activity performance

  Baseline, 8 weeks, and 12 weeks.

Study Arms (1)

LIFT

EXPERIMENTAL

Participants will receive a task-oriented resistance exercise program at home.

Behavioral: Task-oriented resistance exercise

Interventions

Task-oriented resistance exercise BEHAVIORAL

The intervention program includes progressive resistance exercise and daily activity exercise, delivered over a six-week period with an ideal frequency of three sessions per week. Progressive resistance exercise will be provided through a combination of in-person and online sessions, while daily activity exercise will be delivered exclusively in person.

LIFT

Eligibility Criteria

• Age: 65 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• between the ages of 65 and 90 years
• community-dwelling
• live within a 50-mile radius of the study site with wireless connectivity in the area
• mobility limitations as indicated by self-reported of using a mobility aid or having unsteady gait or walking slower than before
• cognitive decline as indicated by a score \< 12 on Mini MoCA Version 2.1
• a care partner or adult family member living in the home or nearby
• willing to wear an activity tracker during the study period

You may not qualify if:

• plan to receive skilled rehabilitation services
• plan to move away outside the study area in two months
• reside in an assisted living or long-term care facility or plan to relocate to such a facility in the next three months
• severe vision or hearing loss that impedes activity performance or communication
• unable to stand or walk even with a mobility aid
• unable to follow a one-step command or carry on a conversation over the phone
• unable to commit to the six-week exercise program
• contradictions to resistance exercise, such as the end-stage heart failure
• a terminal disease or on hospice care
• a neurological condition affecting motor skills
• not able to provide consent.

Sponsors & Collaborators

• University of Florida: lead

Study Sites (2)

College of Public Health and Health Professions, University of Florida

Gainesville, Florida, 32610, United States

RECRUITING

University of Florida

Gainesville, Florida, 32610, United States

NOT YET RECRUITING

MeSH Terms

Conditions

Mobility Limitation; Cognitive Dysfunction; Motor Activity

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Behavior

Study Officials

• Chiung-ju Liu Associate Professor, phD

  University of Florida

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Chiung-ju Liu Associate Professor, PhD

CONTACT

352-273-6496; c.liu1@phhp.ufl.edu

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: One group with repeated measures at baseline, post-intervention, and one-month follow-up.

Study Record Dates

• First Submitted: August 8, 2025
• First Posted: August 15, 2025
• Study Start: January 6, 2026
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): July 31, 2026
• Last Updated: January 8, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will share
• Time Frame: Data requests can be submitted starting 3 months after article publication, and the data will be made accessible for up to 12 months.
• Access Criteria: Access to trial IPD can be requested by qualified researchers engaging in independent scientific research and able to provide a research proposal and data usage agreement. Please contact the trial principal investigator.

Locations

US (2)