Frequency and Predictors of Post-ERCP Pancreatitis in a South Asian Tertiary Care Center

NCT07125014 | Completed DMC

• 1 other identifier: Ref: No.1027/LRH/MTI
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

This study was conducted at the Department of Gastroenterology, Lady Reading Hospital, Peshawar, Pakistan, from January 2023 to December 2023. It aimed to determine how often patients develop pancreatitis (inflammation of the pancreas) after undergoing a procedure called endoscopic retrograde cholangiopancreatography (ERCP), and to identify the main factors that increase this risk. We reviewed the medical records of 300 adult patients who had ERCP for various conditions, such as bile duct stones, tumors, and strictures. We assessed patient characteristics, procedure details, and laboratory results to see which factors were linked to post-ERCP pancreatitis. The study found that prolonged cannulation time, injection of contrast into the pancreatic duct, and high levels of C-reactive protein before the procedure were the strongest predictors of this complication. These findings may help doctors identify high-risk patients and take preventive steps to reduce the chances of pancreatitis after ERCP.

Conditions

Post-ERCP Pancreatitis

Keywords

Endoscopic retrograde cholangiopancreatography; ERCP complications; Pancreatitis risk factors

Outcome Measures

Primary Outcomes (1)

• Incidence of Post-ERCP Pancreatitis

  The number and proportion of patients developing post-ERCP pancreatitis (PEP), defined as new or worsened abdominal pain with serum amylase or lipase levels ≥3 times the upper limit of normal within 24 hours after ERCP, requiring hospitalization or prolongation of hospital stay.

  Within 24 hours after ERCP and during hospitalization

Interventions

Observational study PROCEDURE

This is an observational study with no experimental or therapeutic interventions administered to participants. All data were collected retrospectively from existing hospital records for patients who underwent ERCP between January 2023 and December 2023 at Lady Reading Hospital, Peshawar. No drugs, devices, or procedures were assigned to participants as part of this research.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients undergoing ERCP at the Department of Gastroenterology, Lady Reading Hospital, Peshawar, between January 2023 and December 2023.

You may qualify if:

• Known chronic pancreatitis
• Pancreatic malignancy
• Pre-existing acute pancreatitis
• Incomplete procedural or laboratory records

You may not qualify if:

• Known chronic pancreatitis
• Pancreatic malignancy
• Pre-existing acute pancreatitis
• Incomplete procedural or laboratory records

Sponsors & Collaborators

• Nangarhar University: lead

Study Sites (1)

LRH/MTI

Peshawar, KPK, Pakistan

Location

MeSH Terms

Interventions

Observation

Intervention Hierarchy (Ancestors)

Methods; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: August 9, 2025
• First Posted: August 15, 2025
• Study Start: January 1, 2023
• Primary Completion: December 14, 2023
• Study Completion: December 31, 2023
• Last Updated: August 15, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)