Chinese Migrant Population Health Cohort

NCT07124949 | Recruiting DMC

• 2 other identifiers: HMUIRB2024029PREZY04JD01
• Study Type: observational
• Target: 26,000
• Locations: 1 country
• Sites: 1

Brief Summary

The Chinese Migrant Population Health Cohort is a prospective, multi-center study jointly initiated by Professor Yong Ji, President of Harbin Medical University, and Academician Guoqiang Chen, President of Hainan Medical University, in collaboration with regional partners. It targets older adults (≥60 years) who engage in seasonal migration between cold (Heilongjiang) and tropical (Hainan) regions. The primary objective is to investigate cardiovascular and metabolic disease risks, underlying biological and environmental mechanisms, and effective preventive strategies in this unique population. Participants are recruited from both origin and destination sites and undergo standardized baseline assessments, including questionnaires, physical examinations, medical imaging, biospecimen collection (blood, stool, hair, nails), and environmental exposure monitoring. Longitudinal follow-up includes periodic reassessments, remote monitoring, and data linkage with hospital information systems to capture health outcomes. The study aims to: Define migration-related health risk profiles and disease phenotypes. Elucidate biological and environmental mechanisms influencing disease onset and progression. Develop AI-driven risk prediction models and evaluate targeted interventions through nested randomized controlled trials. Translate findings into clinical guidelines and scalable cross-regional health management models. This is the first cohort in China to systematically investigate the health impacts of seasonal migration in older adults. By integrating epidemiology, multi-omics, environmental data, and health policy translation, the study seeks to improve continuity of care, strengthen climate adaptation, and promote healthy ageing.

Conditions

Cardiovascular Diseases; Metabolic Disorders; Ageing and Geriatric Health; Climate Adaptation

Keywords

Cardiovascular Diseases; Metabolic Diseases; Geriatrics; Migration; Climate Change; Health Promotion

Outcome Measures

Primary Outcomes (1)

• Number of Participants Experiencing First Major Cardiovascular Event

  First occurrence of myocardial infarction, stroke (ischemic or hemorrhagic), or cardiovascular death, confirmed through hospital records, death registries, and adjudication committee review.

  Up to 5 years from baseline

Secondary Outcomes (5)

• Number of Participants with New-Onset Metabolic Disorders

  Up to 5 years from baseline

• Number of Deaths from Any Cause

  Up to 5 years from baseline

• Changes in Cardiometabolic Risk Factors

  Baseline, 2 years, 4 years

• Change in EQ-5D Quality of Life Score from Baseline

  Baseline, 2 years, 4 years

• Change in Cognitive Function Score (MoCA) from Baseline

  Baseline, 2 years, 4 years

Other Outcomes (3)

• Change in Carotid Intima-Media Thickness from Baseline

  Baseline and follow-up imaging

• Change in Coronary Artery Calcium Score from Baseline

  Baseline and follow-up imaging

• Change in Plasma Metabolite Levels from Baseline

  Baseline and follow-up biospecimen analyses

Study Arms (4)

Winter Migrant Group

No Intervention

Other: No intervention

Summer Migrant Group

No Intervention

Other: No intervention

Cold-Region Resident Group

no Intervention

Other: No intervention

Tropical-Region Resident Group

no Intervention

Other: No intervention

Interventions

No intervention OTHER

no intervention

Cold-Region Resident Group; Summer Migrant Group; Tropical-Region Resident Group; Winter Migrant Group

Eligibility Criteria

• Age: 60 Years - 120 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study will enroll community-dwelling adults aged ≥60 years from Harbin (cold region) and Hainan (tropical region), China. Four groups will be included: 1. Winter Migrant Group: \~5,000 Harbin residents who habitually migrate to Hainan during the cold season for ≥2 months each time, with ≥2 consecutive years of such migration and plans to continue; 2. Summer Migrant Group: \~1,000 Hainan residents who habitually migrate to Harbin during the hot season for ≥2 months, with similar migration history and plans; 3. Cold-Region Resident Group: \~10,000 Harbin residents, including matched controls for migrant groups and randomly selected residents, with no \>2 months residence outside Harbin in the past 5 years; 4. Tropical-Region Resident Group: \~10,000 Hainan residents with similar matching criteria and residency requirements. All participants must be able to communicate, perform daily activities independently, consent to long-term follow-up, and provide biospecimens.

You may qualify if:

• Permanent residents of Harbin or Hainan who will continue to reside in Harbin or Hainan for the next 5 years.
• Baseline age ≥60 years, with basic communication and comprehension abilities.
• No confirmed diagnosis of end-stage major organic diseases (e.g., advanced heart failure, advanced liver failure, advanced kidney failure, malignant tumors).
• Able to perform activities of daily living independently and capable of completing questionnaires and physical examinations.
• Willing to participate in the study, provide written informed consent, accept long-term follow-up, and provide biological specimens.

You may not qualify if:

• Occurrence of life-threatening acute events (e.g., myocardial infarction, acute heart failure, stroke) within the past 30 days.
• Currently receiving chronic treatment with antiviral drugs (e.g., for HIV) or antipsychotic medications.
• Presence of moderate to severe cognitive impairment preventing survey completion or follow-up cooperation.
• Current acute infectious diseases such as influenza or fever.
• Simultaneous participation in other interventional clinical studies.
• Refusal to sign informed consent or unwillingness to provide biological specimens.
• Any other condition deemed unsuitable for study participation by the investigators based on overall assessment.

Sponsors & Collaborators

• Jinwei Tian: lead
• Hainan Medical College: collaborator

Study Sites (1)

Harbin Medical University

Harbin, Heilongjiang, 150086,, China

RECRUITING

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Biospecimen

Retention: SAMPLES WITH DNA

Whole blood (serum, plasma, buffy coat, and peripheral blood mononuclear cells), urine, stool, hair, and nail samples will be collected and stored. Blood samples will be processed for biochemical assays, DNA, RNA, and multi-omics analyses (including metabolomics, proteomics, and lipidomics). Urine and stool samples will be analyzed for metabolic, microbiome, and environmental exposure markers. Hair and nail samples will be used for long-term exposure assessment (e.g., heavy metals, stable isotopes). All biospecimens will be stored in a certified biobank at -80 °C for future research.

MeSH Terms

Conditions

Cardiovascular Diseases; Metabolic Diseases

Condition Hierarchy (Ancestors)

Nutritional and Metabolic Diseases

Central Study Contacts

Jinwei Tian, Ph.D.

CONTACT

+86 151 1451 8233; tianjinwei@hrbmu.edu.cn

Cheng Jin, Ph.D.

CONTACT

+86 153 13298872; jinch@hrbmu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: August 11, 2025
• First Posted: August 15, 2025
• Study Start: July 23, 2025
• Primary Completion (Estimated): April 30, 2030
• Study Completion (Estimated): April 30, 2030
• Last Updated: August 20, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)