Prognostic Power of the VEXUS Score in Septic Shock: Effectiveness in Mortality Prediction

NCT07124741 | Not Yet Recruiting

• 1 other identifier: 2024-435
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to evaluate the prognostic power of the VEXUS Score in predicting mortality among patients with septic shock in intensive care units.

Conditions

Septic Shock; VExUS

Outcome Measures

Primary Outcomes (1)

• 28-day intensive care unit mortality in relation to VEXUS score

  Investigation of the relationship between VEXUS Score and 28-day mortality in patients diagnosed with septic shock in the intensive care unit.

  Up to 28 days following intensive care unit admission.

Secondary Outcomes (4)

• Need for mechanical ventilation in relation to VEXUS score

  Within the first 72 hours of intensive care unit admission.

• Duration of mechanical ventilation in relation to VEXUS score.

  From intensive care unit patients admission until extubation, up to 28 days.

• Length of intensive care unit stay in relation to VEXUS score

  From intensive care unit admission until intensive care unit discharge, up to 28 days.

• Vasopressor dose and duration in relation to VEXUS score.

  First 72 hours after intensive care unit admission

Study Arms (1)

Septic shock cohort

All patients diagnosed with septic shock in the ıntensive care unit will undergo serial ultrasonographic evaluations to calculate the VEXUS Score at 0-4 hours, 12-24 hours, and 72 hours. These scores will be analyzed in relation to 28-day mortality. No treatment decisions will be made based on the VEXUS results.

Diagnostic Test: Serial VEXUS Ultrasound Evaluation

Interventions

Serial VEXUS Ultrasound Evaluation DIAGNOSTIC_TEST

Ultrasound assessments will be performed by an experienced anesthesiologist at three time points (0-4 hours, 12-24 hours, and 72 hours)to determine the degree of venous congestion using the VEXUS Score. No treatment changes will be made based on the VEXUS findings. The scores will solely be used for prognostic correlation with mortality outcomes.

Septic shock cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients admitted to the intensive care unit with a diagnosis of septic shock according to Sepsis-3 criteria. Patients will be enrolled consecutively from the intensive care unit of a tertiary care university hospital. Informed consent will be obtained from all patients or their legal representatives.

You may qualify if:

• Age\>18
• Patients monitored for septic shock in intensive care unit
• Signed informed consent

You may not qualify if:

• Age \<18
• Severe obesity precluding adequate ultrasonographic imaging.
• Patients in whom venous structures cannot be clearly assessed via ultrasonography due to anatomical or technical reasons (e.g., adhesions following abdominal surgery).
• Patients receiving dialysis due to chronic kidney disease or initiating dialysis for acute kidney failure.
• Chronic heart failure.
• Patients with advanced valvular insufficiency or advanced pulmonary hypertension.
• Patients with portal hypertension or advanced-stage liver cirrhosis.
• Presence of acute or chronic thrombosis in the inferior vena cava or other venous structures within the scoring area.
• Refusal to participate

Sponsors & Collaborators

• Antalya Training and Research Hospital: lead

MeSH Terms

Conditions

Shock, Septic

Condition Hierarchy (Ancestors)

Sepsis; Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Shock

Study Officials

• Nilgun Kavrut Ozturk, Professor

  University of Health Sciences Antalya Training and Research hospital

  STUDY CHAIR

Central Study Contacts

Nilgun Kavrut Ozturk, Professor

CONTACT

+905334196049; kavrut@yahoo.com

Havva Dikici, Medical Doctor

CONTACT

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: August 8, 2025
• First Posted: August 15, 2025
• Study Start: March 30, 2026
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): August 1, 2026
• Last Updated: August 15, 2025

Record last verified: 2025-08