Oregano and Basil Leaves and Coronary Artery Disease
Effects of Increasing Polyphenol Intake by Consumption of Oregano and Basil Leaves on Plasma Inflammatory and Lipid Factors and Total Urinary Polyphenol in Patients With Unstable Angina
1 other identifier
interventional
70
1 country
1
Brief Summary
The present study will examine the effects of increasing dietary polyphenol intake by consumption of oregano and basil leaves, on plasma inflammatory and lipid factors and total urinary polyphenol levels in patients who have recently had unstable angina.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Sep 2025
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 8, 2025
CompletedFirst Posted
Study publicly available on registry
August 14, 2025
CompletedStudy Start
First participant enrolled
September 1, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 17, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
June 2, 2026
ExpectedNovember 20, 2025
August 1, 2025
7 months
August 8, 2025
November 19, 2025
Conditions
Outcome Measures
Primary Outcomes (2)
Plasma inflammatory biomarkers
Plasma c-reactive protein, Interleukin-6, RANTES (CCL5)
At the beginning of the study and two months later
Plasma lipids
Plasma concentrations of triglyceride, cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol
At the beginning of the study and two months later
Secondary Outcomes (3)
Plasma malondialdehyde
At the beginning of the study and two months later
Urinary total polyphenols
At the beginning of the study and two months later
Plasma PCSK9 and PAI-1 levels
At the beginning of the study and two months later
Study Arms (2)
Control
OTHERStandard medical treatment
Higher polyphenol intake by consumption of oregano and basil
EXPERIMENTALDaily consumption of oregano and basil leaves along with standard medical treatment
Interventions
Patients consume 4-5 grams of dried oregano and 4-5 grams of dried basil leaves daily for two months in addition to their usual medical treatment.
Eligibility Criteria
You may qualify if:
- Patients diagnosed with unstable angina
You may not qualify if:
- Patients diagnosed with STEMI
- Patients undergoing coronary artery bypass grafting
- Liver cirrhosis and advanced chronic kidney disease (CKD 5)
- Having known inflammatory and autoimmune diseases, such as inflammatory bowel disease (IBD) and rheumatoid arthritis, or taking glucocorticoid medications
- Pregnancy or breastfeeding
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Imam Husain hospital
Tehran, Tehran Province, Iran
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
August 8, 2025
First Posted
August 14, 2025
Study Start
September 1, 2025
Primary Completion
March 17, 2026
Study Completion (Estimated)
June 2, 2026
Last Updated
November 20, 2025
Record last verified: 2025-08