Prevention of Hospital Acquired Deconditioning in Hospitalized Acute Leukemia Patients

NCT07122479 | Active Not Recruiting DMC

• 1 other identifier: 23-0527
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 2

Brief Summary

This study aims to decrease the incidence of hospital acquired deconditioning (HAD) and to help standardize daily physical exercise monitoring in acute leukemia patients with anticipated prolonged duration of hospital stay. The investigators hypothesize that implementing a patient-reported adherence log of their recommended standard daily set of exercises will help reduce proportion of hospital acquired deconditioning in acute leukemia patients. The investigators also hypothesize that less adherent patients will have more inpatient hospital related events and decreased health related quality of life.

Conditions

Acute Leukemia

Outcome Measures

Primary Outcomes (1)

• Assess Effectiveness of Prescribed Physical Exercise Program

  daily log of physical exercise adherence and 3) standardize the monitoring of physical exercise by the healthcare team by its inclusion in daily progress notes.

  12 months

Secondary Outcomes (1)

• assess the correlation between patient-reported adherence rate (%) of daily physical exercise

  12 months

Other Outcomes (5)

• Adherence rates of daily physical exercise

  12 months

• Number of days admitted prior to initiation of treatment

  12 months

• Impact of adherence to daily physical activity on re-admission rates

  12 months

Study Arms (1)

Three-Prong Approach to Reduce Hospital Acquired Deconditioning

OTHER

The intervention is a three-prong approach to reduce hospital acquired deconditioning in patients with anticipated prolonged length of stay for acute leukemia chemotherapy. The intervention includes 1) providing and demonstrating a set of daily physical exercises to patient according to their baseline performance status as assessed by physical therapist, 2) maintaining a patient-completed daily log of physical exercise adherence and 3) standardize the monitoring of physical exercise by the healthcare team by its inclusion in daily progress notes.

Other: Three-Pronged Approach to Reduce Hospital Acquired Deconditioning

Interventions

Three-Pronged Approach to Reduce Hospital Acquired Deconditioning OTHER

The intervention includes 1) providing and demonstrating a set of daily physical exercises to patient according to their baseline performance status as assessed by physical therapist, 2) maintaining a patient-completed daily log of physical exercise adherence and 3) standardize the monitoring of physical exercise by the healthcare team by its inclusion in daily progress notes.

Three-Prong Approach to Reduce Hospital Acquired Deconditioning

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 18-99
• Patient admitted to North Shore University Hospital on 7Monti floor
• Diagnosis of acute leukemia (AML or ALL)
• Admitted for treatment with remission inducing therapy either in frontline, relapsed or salvage setting with anticipated hospital length of stay of at least 10 days
• ECOG 0-3 on day of induction.

You may not qualify if:

• Patients admitted for \>14 days prior to initiation of treatment.
• Baseline altered mental status defined by Glasgow coma scale with score less than 15, that does not resolve within first 7 days of treatment as this would preclude participation in physical activity program.
• Baseline disability that would prevent participation in physical activity program.
• CML in acute blast phase.

Sponsors & Collaborators

• Northwell Health: lead

Study Sites (2)

North Shore University Hospital (NSUH)

Manhasset, New York, 11030, United States

Location

Zuckerberg Cancer Center

New Hyde Park, New York, 11042, United States

Location

Study Officials

• Stephanie Boisclair, MD

  Northwell Health

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 7, 2025
• First Posted: August 14, 2025
• Study Start: October 27, 2023
• Primary Completion: May 10, 2024
• Study Completion: August 1, 2025
• Last Updated: August 19, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (2)