Effects of LIFT on Gait and Balance in Spastic Diplegic Cerebral Palsy Children

NCT07121426 | Completed DMC

• 1 other identifier: REC-UOL-287-01-2023
• Study Type: interventional
• Target: 82
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this Randomized control trial was to evaluate the outcome of limb intensive functional training (LIFT) on gait and balance in spastic diplegic cerebral palsy children with age 3-7 years. The main questions this study has answered were:

• To access the improvement in children's gait and balance by providing interventions in clinical setting/ standardized environment and then at home environment. This study will check does the improvement in capacity level also improve their performance level in spastic diplegic CP children after getting targeted, activity focused and therapeutic interventions.
• Researcher will compare the effects of intervention on both groups. Control group will receive Conventional physical therapy and traditional gait training at clinical setting while Experimental group will receive LIFT and conventional physical therapy at home settings provided by their caregivers. Both group will receive intervention 5days/week for 20 consecutive weeks.

Conditions

Spastic Diplegic Cerebral Palsy; Gait, Spastic

Keywords

Cerebral palsy, Balance, Gait, Spastic Diplegia

Outcome Measures

Primary Outcomes (1)

• Gross motor function measure

  GMFM-88 version and clause C, D and E will be used in this study.

  at baseline and after 20 weeks

Secondary Outcomes (3)

• 10 Meter Walk Test (10mwt)

  at baseline and after 20 weeks

• Timed Up and Go Test (Tug)

  at baseline and after 20 weeks

• 30-sec chair rise test

  at baseline and after 20 weeks

Study Arms (2)

Control Group

EXPERIMENTAL

Control group will receive Conventional physical therapy and traditional gait training at clinical setting.

Other: Conventional physical therapy

Intervention Group

EXPERIMENTAL

Experimental group will receive LIFT and conventional physical therapy at home settings provided by their caregivers.

Other: Lower limb Intensive Functional Training; Other: Conventional physical therapy

Interventions

Lower limb Intensive Functional Training OTHER

LIFT will help the child in motor learning, skill progression and resistance training to target the strength, proprioception and coordination impairments of the lower extremities. Motor learning will be based on Strength domain (Cycling) . Balance and Coordination domain involves activities such as (ball kicking with alternate legs and Static standing) Proprioception domain (Vertical jumping, sit to stand and cursing) while applying knee-immobilizers if needed.

Intervention Group

Conventional physical therapy OTHER

Stretching followed by Strengthening program and traditional gait training at clinical setting. Stretching muscles were hip flexors, hip adductors, hamstrings and calf and stretching applied for 30 sec with 30 sec rest for 3-5 times for each muscle group with in pain limit followed by strengthening exercise for week muscle which includes the strengthening of anti-gravity muscles of lower limb they are: Quadriceps, Gluteus maximus and soleus performed in 3 groups. Each group contain 10 rep for each week muscle group.

Control Group; Intervention Group

Eligibility Criteria

• Age: 3 Years - 7 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Children with Spastic diplegic CP with aged 3-7 years Children of both gender Children with MAS level-2 Children with GMFCS level-3 The ability of caregivers to provide one-on-one attention to the child during dailyactivities

You may not qualify if:

• Visual problems preventing performance of interventions and testing tasks59 Any orthopedic or neuro-surgery done in last 1 year60 Children with any other neurological conditions61 Children with uncontrolled seizures62

Sponsors & Collaborators

• University of Lahore: lead

Study Sites (1)

Husna Albab

Lahore, Punjab Province, 54000, Pakistan

Location

Related Publications (1)

• 1. Khumlee N, Suriyaamarit D, Boonyong S. Effects of sensory cues on dynamic trunk control in children with spastic diplegic cerebral palsy. Physiotherapy Theory and Practice 2021: 1-8. 2. Ma Y, Liang Y, Kang X, Shao M, Siemelink L, Zhang Y. Gait characteristics of children with spastic cerebral palsy during inclined treadmill walking under a virtual reality environment. Applied bionics and biomechanics 2019; 2019. 3. Zarkou A, Lee SC, Prosser LA, Jeka JJ. Foot and ankle somatosensory deficits affect balance and motor function in children with cerebral palsy. Frontiers in Human Neuroscience 2020; 14: 45. 4. Tatemoto T, Tanaka S, Maeda K, Tanabe S, Kondo K, Yamaguchi T. Skillful cycling training induces cortical plasticity in the lower extremity motor cortex area in healthy persons. Frontiers in Neuroscience 2019; 13: 927.

  RESULT

MeSH Terms

Conditions

Cerebral Palsy; Gait Disorders, Neurologic

Condition Hierarchy (Ancestors)

Brain Damage, Chronic; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Umair Ahmed, PhD

  University of Lahore

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 18, 2023
• First Posted: August 13, 2025
• Study Start: January 22, 2023
• Primary Completion: June 25, 2023
• Study Completion: July 10, 2023
• Last Updated: August 13, 2025

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)