Comparison of Video Laryngoscopy and Conventional Laryngoscopy for Safe Intubation in Adult Thyroid Surgery Patients With Anticipated Difficult Airway

NCT07113171 | Completed

• 1 other identifier: Sheikh ZMC/H2
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This clinical study is designed to compare two different techniques used for inserting a breathing tube (a process known as intubation) in adult patients undergoing thyroid surgery who are predicted to have a difficult airway. A difficult airway refers to a situation where it may be challenging to place the breathing tube due to specific anatomical or physical factors such as restricted neck movement, enlarged thyroid gland (goiter), reduced mouth opening, short neck, or increased soft tissue around the neck. The two techniques being assessed are conventional direct laryngoscopy, which is the traditional method requiring neck extension for a direct view of the windpipe, and video laryngoscopy, a modern approach that uses a camera to visualize the vocal cords on a screen with less need for neck manipulation. In this randomized controlled trial, a total of 60 patients meeting the eligibility criteria will be included and randomly assigned into two equal groups. One group will undergo intubation using the conventional laryngoscope, while the other group will be intubated using the video laryngoscope. The primary aim of this research is to evaluate which method provides a higher success rate of placing the endotracheal tube correctly on the first attempt. Additional outcomes that will be assessed include the total time taken for intubation, whether the intubation was ultimately successful regardless of the number of attempts, and the occurrence of any immediate injuries within the mouth or throat area during or after the procedure. The underlying hypothesis of the study is that video laryngoscopy will result in a significantly higher first-attempt intubation success rate as compared to conventional laryngoscopy in patients with predicted difficult airways. This study intends to provide clinically useful evidence to guide anesthesiologists in selecting the most effective and safe intubation technique for patients undergoing thyroid surgery, with the goal of minimizing complications and improving procedural outcomes.

Conditions

Difficult Airway Intubation; Airway Management During Operative Procedure

Keywords

Airway Management in Thyroid Surgery; Endotracheal Intubation Techniques; Video Laryngoscopy; Direct Laryngoscopy; Anesthesia in Thyroid Disorders

Outcome Measures

Primary Outcomes (1)

• First-Attempt Intubation Success Rate

  Successful placement of the endotracheal tube through the vocal cords into the trachea on the first attempt, confirmed by bilateral chest auscultation and capnography.

  During intubation at the time of induction of anesthesia (Day 0, intraoperative)

Secondary Outcomes (3)

• Overall Intubation Success Rate

  During intubation at the time of induction of anesthesia (Day 0, intraoperative)

• Intubation Time

  During intubation at the time of induction of anesthesia (Day 0, intraoperative)

• Incidence of Immediate Oropharyngeal Injuries

  Immediately post-intubation (within 5 minutes of tube placement, intraoperative)

Study Arms (2)

Group A - Conventional Laryngoscopy

ACTIVE COMPARATOR

Received endotracheal intubation using conventional direct laryngoscope with a Macintosh blade, performed under general anesthesia in patients undergoing thyroid surgery.

Device: Conventional Direct Laryngoscope

Group B - Video Laryngoscopy

EXPERIMENTAL

Received endotracheal intubation using video laryngoscope under general anesthesia in patients undergoing thyroid surgery.

Device: Video Laryngoscope

Interventions

Conventional Direct Laryngoscope DEVICE

The Macintosh laryngoscope blade was used for intubation. The technique involved neck extension to create a direct line of sight to the vocal cords for successful tracheal tube placement.

Also known as: Direct Laryngoscope

Group A - Conventional Laryngoscopy

Video Laryngoscope DEVICE

The video laryngoscope allowed visualization of the glottis on a monitor without the need for cervical extension, facilitating intubation in anticipated difficult airway cases.

Also known as: Indirect Laryngoscope

Group B - Video Laryngoscopy

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age from 18 to 60 years
• Both genders will be included
• Patients requiring endotracheal intubation under general anaesthesia for thyroid surgery.
• Patients with anticipated difficult intubation based on the preoperative airway assessment.
• Patients having ASA (American College of Anaesthesiologists) class 1 to 2.

You may not qualify if:

• Patients having neck injury
• Patients having cervical spondylopathy
• Patients requiring urgent/ emergency thyroid surgery
• Patients with existing oropharyngeal or laryngeal abnormalities.
• Patients with a history of severe cardiovascular or respiratory diseases.

Sponsors & Collaborators

• Sheikh Zayed Medical College: lead

Study Sites (1)

Sheikh Zayed Medical college/hospital

Rahim Yar Khan, Punjab Province, 66000, Pakistan

Location

Study Officials

• Muhammad Irfan Jamil

  Sheikh Zayed Medical college/Hospital, Rahimyar Khan

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: August 2, 2025
• First Posted: August 8, 2025
• Study Start: November 18, 2023
• Primary Completion: May 18, 2024
• Study Completion: May 18, 2024
• Last Updated: August 8, 2025

Record last verified: 2025-08

Locations

PA (1)