Robot-assisted Adrenalectomy, Feasibility and Results

NCT07110168 | Active Not Recruiting DMC

• 1 other identifier: 2025PI122
• Study Type: observational
• Target: 700
• Locations: 1 country
• Sites: 1

Brief Summary

To date, laparoscopy is considered to be the gold standard technique for adrenalectomy. Robotic surgery is beginning to be used, but no series of more than 300 procedures has yet allowed the morbidity, benefits and learning curve of this technique to be assessed. Furthermore, the debate on the benefits of using robotic tools when performing adrenalectomies remains open. At Nancy University Hospital, we have been performing robotic procedures on 90% of our patients since 2009, and have seen a significant increase in patient numbers (currently between 80 and 90 per year). In 2019, we published a series of 300 patients, describing the results of the technique. Based on our clinical experience and the growing interest of the surgical community, we believe that describing our cohort of patients who have undergone robot-assisted surgery (estimated at 600 patients) is of unquestionable scientific interest. In 2018, the American team at UCLA published a series of 640 laparoscopic adrenalectomies and examined the risk factors for complications following this surgery. Given the team's reputation and their publication in the leading surgical journal (JAMA Surgery), we used the same criteria for our data collection to make our results comparable. This study aims to evaluate the risk factors for surgical complications after robotic adrenalectomy in a large retrospective series. Our aim is to demonstrate the safety and reliability of this technique and to identify patients at greatest risk of complications. This may encourage the adoption of the technique in other centres.

Conditions

Adrenalectomy

Keywords

adrenalectomy; robotic surgery; robot-assisted surgery; transperitoneal adrenalectomy

Outcome Measures

Primary Outcomes (1)

• Morbidity after robotic adrenalectomy

  evaluation of morbidity after robotic adrenalectomy in the 30 days after surgery using Clavien Dindo classification

  from enrollment to 30 days after surgery

Secondary Outcomes (3)

• factors associated with clavien Dindo morbidity>2

  from enrollment to 30 days after surgery

• Learning curve

  from enrollment to 30 days after surgery

• Learning curve - operative time

  from enrollment to 30 days after surgery

Study Arms (1)

patients who underwent robot assisted adrenalectomy in University Hospital of Nancy

All patients who underwent a robotic adrenalectomy (all adrenal disease included) in the Department of Visceral,Metabolic and Oncologic surgery in University Hospital of Nancy between 01.01.2013 and 12.31.2025.

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients who underwent robot-assisted adrenalectomy in Department of Visceral Metabolic and Oncologic surgery Department

You may qualify if:

• all patient who underwent unilateral robot-assisted adrenalectomy

You may not qualify if:

• bilateral adrenalectomy
• adrenalectomy by laparotomy
• partial adrenalectomy

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

Study Sites (1)

Nomine-Criqui Claire

Nancy, Lorraine, 54000, France

Location

Related Publications (5)

• Bihain F, Klein M, Nomine-Criqui C, Brunaud L. Robotic adrenalectomy in patients with pheochromocytoma: a systematic review. Gland Surg. 2020 Jun;9(3):844-848. doi: 10.21037/gs-2019-ra-05.

  PMID: 32775278 BACKGROUND

• Giordano A, Balla A, Prosperi P, Morales-Conde S, Bergamini C. Robotic vs. Laparoscopic Adrenalectomy for Pheochromocytoma-A Systematic Review and Meta-Analysis. J Clin Med. 2025 May 29;14(11):3806. doi: 10.3390/jcm14113806.

  PMID: 40507569 BACKGROUND

• Li X, Xiao S, Yu Y, Liu W, Xi H, Wang G, Zhou X. Robotic-assisted laparoscopic adrenalectomy (RARLA): What advantages and disadvantages compared to retroperitoneal laparoscopic adrenalectomy (RLA)? Front Endocrinol (Lausanne). 2023 Mar 2;14:1145820. doi: 10.3389/fendo.2023.1145820. eCollection 2023.

  PMID: 36936166 BACKGROUND

• Chen Y, Scholten A, Chomsky-Higgins K, Nwaogu I, Gosnell JE, Seib C, Shen WT, Suh I, Duh QY. Risk Factors Associated With Perioperative Complications and Prolonged Length of Stay After Laparoscopic Adrenalectomy. JAMA Surg. 2018 Nov 1;153(11):1036-1041. doi: 10.1001/jamasurg.2018.2648.

  PMID: 30090934 BACKGROUND

• Greilsamer T, Nomine-Criqui C, Thy M, Ullmann T, Zarnegar R, Bresler L, Brunaud L. Robotic-assisted unilateral adrenalectomy: risk factors for perioperative complications in 303 consecutive patients. Surg Endosc. 2019 Mar;33(3):802-810. doi: 10.1007/s00464-018-6346-2. Epub 2018 Jul 11.

  PMID: 29998394 BACKGROUND

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor - Head of the endocrine surgery unit of the department of metabolic, endocrine and oncologic surgery

Study Record Dates

• First Submitted: July 31, 2025
• First Posted: August 7, 2025
• Study Start: May 30, 2025
• Primary Completion: August 30, 2025
• Study Completion (Estimated): August 30, 2026
• Last Updated: August 7, 2025

Record last verified: 2025-07

Locations

FR (1)